First, we performed a survey of the published literature using GRAIL22, to search for connectivity between the genes and specific keywords that describe these functional connections (see Online Methods). Although there was no evidence, after correcting for multiple testing, that the connectivity between these genes was greater than chance, we identified 8 genes with nominal significance (P < 0.05) for potential functional connectivity (PLXND, HOXC10, TBX15, RSPO3, HOXC4, HOXC6, KREMEN1 and HOXC11). The keywords associated with these connections included “vegf”, “homeobox”, “patterning”, “mesenchyme”, “embryonic”, “development” and “angiogenesis”.
