Chunk #10 — RESULTS — Pathway analysis of the WHR-associated loci and potential biological role

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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

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To identify potential functional connections and pathway relationships between genes mapping at the WHR-associated loci, we focused on the 95 genes located in a 2 Mb interval centered around each of the 48 independent SNPs that attained a P < 1.0 × 10−5 in the WHR discovery studies.