Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
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- Authors
- Thorleifsson, Gudmar; Walters, G Bragi; Gudbjartsson, Daniel F; Steinthorsdottir, Valgerdur; Sulem, Patrick; Helgadottir, Anna; Styrkarsdottir, Unnur; Gretarsdottir, Solveig; Thorlacius, Steinunn; Jonsdottir, Ingileif; Jonsdottir, Thorbjorg; Olafsdottir, Elinborg J; Olafsdottir, Gudridur H; Jonsson, Thorvaldur; Jonsson, Frosti; Borch-Johnsen, Knut; Hansen, Torben; Andersen, Gitte; Jorgensen, Torben; Lauritzen, Torsten; Aben, Katja K; Verbeek, AndrΓ© L M; Roeleveld, Nel; Kampman, Ellen; Yanek, Lisa R; Becker, Lewis C; Tryggvadottir, Laufey; Rafnar, Thorunn; Becker, Diane M; Gulcher, Jeffrey; Kiemeney, Lambertus A; Pedersen, Oluf; Kong, Augustine; Thorsteinsdottir, Unnur; Stefansson, Kari
- Year
- 2009
- Journal
- Nature genetics
- PMID
- 19079260
- DOI
- 10.1038/ng.274
Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are highly heritable, we performed a genome-wide association (GWA) study with 305,846 SNPs typed in 25,344 Icelandic, 2,998 Dutch, 1,890 European Americans and 1,160 African American subjects and combined the results with previously published results from the Diabetes Genetics Initiative (DGI) on 3,024 Scandinavians. We selected 43 variants in 19 regions for follow-up in 5,586 Danish individuals and compared the results to a genome-wide study on obesity-related traits from the GIANT consortium. In total, 29 variants, some correlated, in 11 chromosomal regions reached a genome-wide significance threshold of P < 1.6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity.
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| The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population. | da Fonseca ACP et al. | β | 2019 | β |
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| The FTO rs9939609 "A" allele is associated with impaired fasting glucose and insulin resistance in Emirati population. | Saber-Ayad M et al. | β | 2019 | β |
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| HLA-B*07, HLA-DRB1*07, HLA-DRB1*12, and HLA-C*03:02 Strongly Associate With BMI: Data From 1.3 Million Healthy Chinese Adults. | Shen J et al. | β | 2018 | β |
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| Low Salivary Amylase Gene (<i>AMY1</i>) Copy Number Is Associated with Obesity and Gut <i>Prevotella</i> Abundance in Mexican Children and Adults. | LeΓ³n-Mimila P et al. | β | 2018 | β |
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| Smoking modifies the effect of two independent SNPs rs5063 and rs198358 of NPPA on central obesity in the Chinese Han population. | Zhang H et al. | β | 2018 | β |
| The BDNF rs6265 variant may interact with overweight and obesity to influence obesity-related physical, metabolic and behavioural traits in Pakistani individuals. | Rana S et al. | β | 2018 | β |
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| Associations of Two Obesity-Related Single-Nucleotide Polymorphisms with Adiponectin in Chinese Children. | Wu L et al. | β | 2017 | β |
| BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort. | Graff M et al. | β | 2017 | β |
| Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort. | Jiang R et al. | β | 2017 | β |
| Cardiovascular Risk Factors and Insulin Resistance after Two Hypocaloric Diets with Different Fat Distribution in Obese Subjects: Effect of the rs10767664 Gene Variant in Brain-Derived Neurotrophic Factor. | de Luis DA et al. | β | 2017 | β |
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| rs10767664 Gene Variant in Brain-Derived Neurotrophic Factor Is Associated with Diabetes Mellitus Type 2 in Caucasian Females with Obesity. | de Luis DA et al. | β | 2017 | β |
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| Structural variants caused by <i>Alu</i> insertions are associated with risks for many human diseases. | Payer LM et al. | β | 2017 | β |
| The Brain-Derived Neurotrophic Factor Val66Met Polymorphism, Delivery Method, Birth Weight, and Night Sleep Duration as Determinants of Obesity in Vietnamese Children of Primary School Age. | Tuyet LT et al. | β | 2017 | β |
| The contribution of genetics and environment to obesity. | Albuquerque D et al. | β | 2017 | β |
| The ETS-5 transcription factor regulates activity states in <i>Caenorhabditis elegans</i> by controlling satiety. | Juozaityte V et al. | β | 2017 | β |
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| The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs. | Loviglio MN et al. | β | 2017 | β |
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| What has GWAS done for HLA and disease associations? | Kennedy AE et al. | β | 2017 | β |
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