Implication of European-derived adiposity loci in African Americans.

paper Cited Public

Authors: Hester, J M; Wing, M R; Li, J; Palmer, N D; Xu, J; Hicks, P J; Roh, B H; Norris, J M; Wagenknecht, L E; Langefeld, C D; Freedman, B I; Bowden, D W; Ng, M C Y
Year: 2012
Journal: International journal of obesity (2005)
PMID: 21750520
DOI: 10.1038/ijo.2011.131
PMCID: PMC3306054

#	Section	Preview
0	Introduction	Obesity is a major public health problem leading to increased mortality and comorbidities, such as…
1	Introduction	Marked racial and gender differences in the prevalence of obesity have been observed. In the…
2	Introduction	The increasing prevalence of obesity is contributed by the excessive caloric intake and diminished…
3	Introduction	Recently, large-scale genome-wide association studies (GWAS) and meta-analyses in Europeans have…
4	Subjects and methods — Subjects	Six African-American cohorts were used in the present study. Cohorts 1 and 2 were derived from a…
5	Subjects and methods — Subjects	503 related subjects from 178 nuclear families) was recruited from the community, churches, health…
6	Subjects and methods — Subjects	The clinical characteristics of all cohorts are summarized in Table 1. Informed consent was obtained…
7	Subjects and methods — Clinical studies	Height and weight was measured in all study subjects. BMI is calculated as weight divided by square…
8	Subjects and methods — Genotyping and quality control	A total of 46 SNPs at 19 novel adiposity loci, identified through recent GWAS in Europeans, were…
9	Subjects and methods — Genotyping and quality control	cluster boundaries. Genotyping of samples from cohorts 3 to 6 was performed using the iPLEX Sequenom…
10	Subjects and methods — Imputation of genotypes for cohorts 1 and 2	Imputation was performed for autosomes using MACH (version 1.0.16,…
11	Subjects and methods — Population structure	To account for the effect of population structure on genetic association in these African-American…
12	Subjects and methods — Statistical analyses	Data are presented as mean±s.d. or percentage, as appropriate. BMI was natural logarithmically…
13	Subjects and methods — Statistical analyses — Association	For cohorts 1 and 2, the associations of BMI Z-scores with SNPs were tested by linear regression…
14	Subjects and methods — Statistical analyses — Meta-analysis	Association results from all six cohorts were combined using the inverse variance weighted method…
15	Subjects and methods — Statistical analyses — Meta-analysis	All statistical tests were performed by QSNPGWA, PLINK (http://pngu.mgh.harvard.edu/~purcell/plink/)…
16	Results — Clinical characteristics of the study samples	The clinical characteristics of the study samples in all six cohorts are shown in Table 1. Due to…
17	Results — Clinical characteristics of the study samples	We either genotyped or imputed (for 24 SNPs in cohorts 1 and 2 only) 46 representative SNPs in 19…
18	Results — Clinical characteristics of the study samples	and rs2568958 are highly correlated with each other (r2 = 0.99), but moderately correlated with…
19	Results — Clinical characteristics of the study samples	We further investigated the association of these 46 SNPs in 2111 community non-diabetic, 1516…

Name	Type
adiposity	phenotype
adiposity measures	phenotype
Affymetrix Genome-wide Human SNP array 6.0	drug
African American	cohort
African-American cohorts local	cohort
African American Diabetes Heart Study local	cohort
African-Americans	cohort
African-derived populations local	cohort
age	phenotype
Ancestry informative markers local	phenotype
Asian	cohort
ATP2A1	gene
BCDIN3D local	gene
Bdnf	gene
black men	cohort
black women	cohort
BMI	phenotype
BMI z-score	phenotype
body weight	phenotype
brain	anatomy
brain development	phenotype
C-allele local	variant
cancer	phenotype
CDH12	gene
cell movement local	phenotype
CEU	cohort
childhood obesity	phenotype
CHST8	gene
Cohort 3-6 local	cohort
community-based local	phenotype
coronary artery disease	phenotype
coronary heart disease	phenotype
CTNNBL1	gene
Dgkg	anatomy
diabetes	phenotype
Diabetes Heart Studies cohort local	cohort
Diabetes Heart Study local	cohort
diabetic nephropathy local	phenotype
end-stage renal disease local	phenotype
ESRD local	phenotype
ETV5	gene
European American children local	cohort
European ancestry	cohort
European-derived local	cohort
European-derived cohorts local	cohort
European-derived populations local	cohort
European population	cohort
Europeans	cohort
European studies	cohort
extreme obesity	phenotype
FAIM2	gene
FTO	gene
Gallbladder Disease local	phenotype
genomic DNA	drug
glioma-directed stem cell migration local	phenotype
glucose homeostasis traits local	phenotype
GNPDA2	gene
healthy controls	cohort
hyperinsulinemia	phenotype
hyperphagia	phenotype
hypertension	phenotype
hypothalamus	anatomy
Insulin Resistance Atherosclerosis (IRAS) Studies cohort local	cohort
iPLEX Sequenom MassARRAY local	drug
iPLEX Sequenom MassARRAY platform local	drug
IRAS Family Study local	cohort
IRAS Study local	cohort
KCTD15	gene
leptin	drug
LGR4 local	gene
LIN7C	gene
liver disease	phenotype
LYPlAL1	gene
MAF	gene
MC4R	gene
metabolic syndrome	phenotype
MSRA	gene
MTCH2	gene
multiple African-American populations local	cohort
National Health and Nutrition Examination Survey 2003-2004 local	cohort
NEGR1	gene
non-diabetic local	phenotype
Non-diabetic subjects local	phenotype
non-Hispanic whites	cohort
NPC1	gene
NRXN3	gene
obesity	phenotype
osteoarthritis	phenotype
PARD3B local	gene
PC1	phenotype
Pcsk1	gene
Pedcheck	drug
PRL local	gene
PTER	gene
RASAL2 local	gene
risk factor	phenotype
rs10508503	variant
rs10871777 local	variant
rs12457166 local	variant
rs17782313	variant
rs1942880 local	variant
rs2568958 local	variant
rs2867125 local	variant
rs3101336 local	variant
rs3751812 local	variant
rs4450508 local	variant
rs4712652 local	variant
rs476828 local	variant
rs477181 local	variant
rs571312	variant
rs633265 local	variant
rs6567160 local	variant
rs7498665	variant
rs8050136	variant
rs94224977 local	variant
rs9424977 local	variant
rs9939609	variant
SEC16B	gene
sex	phenotype
SFRS10	gene
SH2B1	gene
six African-American cohorts local	cohort
six cohorts local	cohort
Six Cohorts local	cohort
Sleep Disorders local	phenotype
SNP	cohort
SNPs_at_novel_adiposity_loci local	variant
stroke	phenotype
study cohort	cohort
sub-clinical cardiovascular risk local	phenotype
subjects with T2DM local	cohort
subjects with T2DM-ESRD local	cohort
T2DM	phenotype
T2DM-ESRD local	phenotype
T2DM–ESRD local	phenotype
T-allele local	variant
TCF7L2	gene
TFAP2B	gene
TMEM18	gene
total fat	phenotype
type 2 diabetes	phenotype
visceral adipose tissue	phenotype
waist circumference	phenotype
waist-to-hip ratio	phenotype
weight regulation	phenotype
YRI	cohort

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In this knowledge base

Title	Year	PMID
On the association of common and rare genetic variation influencing body mass index: a combined SNP and CNV analysis.	2014	24884913
The bigger picture of FTO: the first GWAS-identified obesity gene.	2014	24247219

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