Genome-wide association of anthropometric traits in African- and African-derived populations.
paper
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- Authors
- Kang, Sun J; Chiang, Charleston W K; Palmer, Cameron D; Tayo, Bamidele O; Lettre, Guillaume; Butler, Johannah L; Hackett, Rachel; Adeyemo, Adebowale A; Guiducci, Candace; Berzins, Ilze; Nguyen, Thutrang T; Feng, Tao; Luke, Amy; Shriner, Daniel; Ardlie, Kristin; Rotimi, Charles; Wilks, Rainford; Forrester, Terrence; McKenzie, Colin A; Lyon, Helen N; Cooper, Richard S; Zhu, Xiaofeng; Hirschhorn, Joel N
- Year
- 2010
- Journal
- Human molecular genetics
- PMID
- 20400458
- DOI
- 10.1093/hmg/ddq154
- PMCID
- PMC2883343
Genome-wide association (GWA) studies have identified common variants that are associated with a variety of traits and diseases, but most studies have been performed in European-derived populations. Here, we describe the first genome-wide analyses of imputed genotype and copy number variants (CNVs) for anthropometric measures in African-derived populations: 1188 Nigerians from Igbo-Ora and Ibadan, Nigeria, and 743 African-Americans from Maywood, IL. To improve the reach of our study, we used imputation to estimate genotypes at approximately 2.1 million single-nucleotide polymorphisms (SNPs) and also tested CNVs for association. No SNPs or common CNVs reached a genome-wide significance level for association with height or body mass index (BMI), and the best signals from a meta-analysis of the two cohorts did not replicate in approximately 3700 African-Americans and Jamaicans. However, several loci previously confirmed in European populations showed evidence of replication in our GWA panel of African-derived populations, including variants near IHH and DLEU7 for height and MC4R for BMI. Analysis of global burden of rare CNVs suggested that lean individuals possess greater total burden of CNVs, but this finding was not supported in an independent European population. Our results suggest that there are not multiple loci with strong effects on anthropometric traits in African-derived populations and that sample sizes comparable to those needed in European GWA studies will be required to identify replicable associations. Meta-analysis of this data set with additional studies in African-ancestry populations will be helpful to improve power to detect novel associations.
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|---|---|---|---|---|
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| Genetic differentiation in East African ethnicities and its relationship with endurance running success. | Zani ALS et al. | — | 2022 | → |
| Genome-Wide Association Study and Selective Sweep Analysis Reveal the Genetic Architecture of Body Weights in a Chicken F<sub>2</sub> Resource Population. | Wang S et al. | — | 2022 | → |
| The accelerated aging phenotype: The role of race and social determinants of health on aging. | Noren Hooten N et al. | — | 2022 | → |
| Transcriptome analysis reveals the potential roles of long non-coding RNAs in feed efficiency of chicken. | Karimi P et al. | — | 2022 | → |
| Allele frequency differentiation at height-associated SNPs among continental human populations. | Chen M et al. | — | 2021 | → |
| Disentangling sex differences in the shared genetic architecture of posttraumatic stress disorder, traumatic experiences, and social support with body size and composition. | Muniz Carvalho C et al. | — | 2021 | → |
| Genetics of Obesity in East Asians. | Sun C et al. | — | 2020 | → |
| Complex Phenotypes: Mechanisms Underlying Variation in Human Stature. | Muthuirulan P et al. | — | 2019 | → |
| Prospects of genetic testing for steroid-resistant nephrotic syndrome in Nigerian children: a narrative review of challenges and opportunities. | Anigilaje EA et al. | — | 2019 | → |
| A study of Kibbutzim in Israel reveals risk factors for cardiometabolic traits and subtle population structure. | Granot-Hershkovitz E et al. | — | 2018 | → |
| Ethnic and population differences in the genetic predisposition to human obesity. | Stryjecki C et al. | — | 2018 | → |
| Genetic variants in SEC16B are associated with body composition in black South Africans. | Sahibdeen V et al. | — | 2018 | → |
| Genome-Wide Association Analysis of Age-Dependent Egg Weights in Chickens. | Liu Z et al. | — | 2018 | → |
| Medical genetics and genomic medicine in Nigeria. | Adeyemo AA et al. | — | 2018 | → |
| A study of Kibbutzim in Israel reveals risk factors for cardiometabolic traits and subtle population structure | Granot-Hershkovitz E et al. | — | 2017 | — |
| BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort. | Graff M et al. | — | 2017 | → |
| Calibrating Population Stratification in Association Analysis. | Qin H et al. | — | 2017 | → |
| Diversity and inclusion in genomic research: why the uneven progress? | Bentley AR et al. | — | 2017 | → |
| Height associated variants demonstrate assortative mating in human populations. | Li X et al. | — | 2017 | → |
| Rare coding variants associated with blood pressure variation in 15 914 individuals of African ancestry. | Nandakumar P et al. | — | 2017 | → |
| Retracted: Influence of genetic variants of IDH1, IDH2, TET2 and DNMT3A on cytarabine cytotoxicity in different populations. | Wang Y et al. | — | 2017 | → |
| Evidence for Association between SH2B1 Gene Variants and Glycated Hemoglobin in Nondiabetic European American Young Adults: The Add Health Study. | Lange LA et al. | — | 2016 | → |
| Genome-wide association study of antibody responses to Plasmodium falciparum candidate vaccine antigens. | Milet J et al. | — | 2016 | → |
| Composite Selection Signals for Complex Traits Exemplified Through Bovine Stature Using Multibreed Cohorts of European and African Bos taurus. | Randhawa IA et al. | — | 2015 | → |
| Genetic association studies of obesity in Africa: a systematic review. | Yako YY et al. | — | 2015 | → |
| Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease. | Peprah E et al. | — | 2015 | → |
| Genomic research in Zambia: confronting the ethics, policy and regulatory frontiers in the 21st Century. | Chanda-Kapata P et al. | — | 2015 | → |
| Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity. | Apalasamy YD et al. | — | 2015 | → |
| Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. | Evans DS et al. | — | 2014 | → |
| Interleukin-6 gene polymorphisms, dietary fat intake, obesity and serum lipid concentrations in black and white South African women. | Joffe YT et al. | — | 2014 | → |
| Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort. | Richardson AS et al. | — | 2014 | → |
| On the association of common and rare genetic variation influencing body mass index: a combined SNP and CNV analysis. | Peterson RE et al. | — | 2014 | → |
| A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. | Monda KL et al. | — | 2013 | → |
| Genetics of obesity and type 2 diabetes in African Americans. | McCormack S et al. | — | 2013 | → |
| Genome-wide association study of age at menarche in African-American women. | Demerath EW et al. | — | 2013 | → |
| Next generation sequencing and rare genetic variants: from human population studies to medical genetics. | Matullo G et al. | — | 2013 | → |
| Obesity genomics: assessing the transferability of susceptibility loci across diverse populations. | Lu Y et al. | — | 2013 | → |
| Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations. | Ding L et al. | — | 2013 | → |
| Recent human adaptation: genomic approaches, interpretation and insights. | Scheinfeldt LB et al. | — | 2013 | → |
| Replication and fine mapping of asthma-associated loci in individuals of African ancestry. | Kantor DB et al. | — | 2013 | → |
| Screen time behaviours may interact with obesity genes, independent of physical activity, to influence adolescent BMI in an ethnically diverse cohort. | Graff M et al. | — | 2013 | → |
| The Role of Copy Number Variation in African Americans with Type 2 Diabetes-Associated End Stage Renal Disease. | Bailey JN et al. | — | 2013 | → |
| Adrenergic alpha-1 pathway is associated with hypertension among Nigerians in a pathway-focused analysis. | Reder NP et al. | — | 2012 | → |
| Allowing for population stratification in association analysis. | Qin H et al. | — | 2012 | → |
| Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study. | Lombard Z et al. | — | 2012 | → |
| Assessment of genotype imputation performance using 1000 Genomes in African American studies. | Hancock DB et al. | — | 2012 | → |
| Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain. | Malhotra AK et al. | — | 2012 | → |
| Copy number variations associated with obesity-related traits in African Americans: a joint analysis between GENOA and HyperGEN. | Zhao W et al. | — | 2012 | → |
| Gencrypt: one-way cryptographic hashes to detect overlapping individuals across samples. | Turchin MC et al. | — | 2012 | → |
| Genetic determinants of common obesity and their value in prediction. | Loos RJ | — | 2012 | → |
| Genome-wide association of BMI in African Americans. | Ng MC et al. | — | 2012 | → |
| Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe). | Carty CL et al. | — | 2012 | → |
| Genome-wide association study of lung function decline in adults with and without asthma. | Imboden M et al. | — | 2012 | → |
| Implication of European-derived adiposity loci in African Americans. | Hester JM et al. | — | 2012 | → |
| Patterns of ancestry, signatures of natural selection, and genetic association with stature in Western African pygmies. | Jarvis JP et al. | — | 2012 | → |
| Power comparison of admixture mapping and direct association analysis in genome-wide association studies. | Qin H et al. | — | 2012 | → |
| The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO. | Jacobsson JA et al. | — | 2012 | → |
| Adjustment for local ancestry in genetic association analysis of admixed populations. | Wang X et al. | — | 2011 | → |
| Africa: the next frontier for human disease gene discovery? | Ramsay M et al. | — | 2011 | → |
| Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. | Fox ER et al. | — | 2011 | → |
| Developments in obesity genetics in the era of genome-wide association studies. | Day FR et al. | — | 2011 | → |
| Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans. | Lo KS et al. | — | 2011 | → |
| Genetic background of patients from a university medical center in Manhattan: implications for personalized medicine. | Tayo BO et al. | — | 2011 | → |
| Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study. | Dumitrescu L et al. | — | 2011 | → |
| Genome-wide association of copy-number variation reveals an association between short stature and the presence of low-frequency genomic deletions. | Dauber A et al. | — | 2011 | → |
| Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. | Lettre G et al. | — | 2011 | → |
| Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans. | Wheeler HE et al. | — | 2011 | → |
| Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. | N'Diaye A et al. | — | 2011 | → |
| Interaction of FTO and physical activity level on adiposity in African-American and European-American adults: the ARIC study. | Demerath EW et al. | — | 2011 | → |
| Perspectives on human population structure at the cusp of the sequencing era. | Novembre J et al. | — | 2011 | → |
| Recent progress in the study of the genetics of height. | Lettre G | — | 2011 | → |
| The efficacy of detecting variants with small effects on the Affymetrix 6.0 platform using pooled DNA. | Chiang CW et al. | — | 2011 | → |
| The genetic epidemiology of melanocortin 4 receptor variants. | Loos RJ | — | 2011 | → |
| Whole-genome resequencing in pharmacogenomics: moving away from past disparities to globally representative applications. | Drögemöller BI et al. | — | 2011 | → |
| Interrogating local population structure for fine mapping in genome-wide association studies. | Qin H et al. | — | 2010 | → |