cluster boundaries. Genotyping of samples from cohorts 3 to 6 was performed using the iPLEX Sequenom MassARRAY platform (San Diego, CA, USA). The minimum and average SNP call rates for all cohorts were 95% and 98.1%, respectively. The average genotype concordance rate of 45 blind duplicates was 99.8%. All SNPs had Hardy-Weinberg P-value ≥0.001 in the combined unrelated samples. For related samples, genotype data identified with Mendelian inconsistency by PedCheck (v. 1.1)38 were removed.
