We either genotyped or imputed (for 24 SNPs in cohorts 1 and 2 only) 46 representative SNPs in 19 adiposity loci reported in recent GWAS in six African-American cohorts. Table 2 summarizes the individual cohort and meta-analysis results of these SNPs for association with BMI, using an inverse variance method. From the results of the meta-analysis, seven SNPs showed significant association at 0.005<P<0.05 with effect sizes between 0.04 and 0.06 s.d. units (or 0.30 to 0.44 kg m−2) of BMI for each copy of effect allele. These seven SNPs were located at, or near four different loci including, NEGR1, TMEM18, SH2B1/ATP2A1 and MC4R. The most significantly associated SNPs (rs9424977, rs3101336 and rs2568958) are located on chromosome 1 near NEGR1 (0.005<P<0.02). The T-allele of rs9424977 showed a trend of association with increased BMI in four of the six cohorts. The rs3101336 and rs2568958 are highly correlated with each other (r2 = 0.99), but moderately correlated with rs9424977 (r2 0.55)= in our samples. Conditional analysis including both rs9424977 and rs3101336 removed the significant associations (P = 0.175 for rs9424977 and 0.676 for
