We selected SNPs representing the top 16 independent (> 1 Mb distance) regions of association (discovery P < 1.4 × 10−6, Table 1) and evaluated them in 29 additional, independent studies (up to 113,636 individuals) using a mixture of in silico data and de novo genotyping. In these follow-up studies, 14 of the 16 showed strong directionally-consistent evidence for replication (P < 1.0 × 10−3) and ten reached genome-wide significance (P < 5.0 × 10−8). Joint analysis of the discovery and follow-up results revealed genome-wide significant associations for 14 signals (P between 1.9 × 10−9 and 1.8 × 10−40, Table 1).
