Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
paper
Cited
Public
- Authors
- Wheeler, Eleanor; Huang, Ni; Bochukova, Elena G; Keogh, Julia M; Lindsay, Sarah; Garg, Sumedha; Henning, Elana; Blackburn, Hannah; Loos, Ruth J F; Wareham, Nick J; O'Rahilly, Stephen; Hurles, Matthew E; Barroso, InΓͺs; Farooqi, I Sadaf
- Year
- 2013
- Journal
- Nature genetics
- PMID
- 23563609
- DOI
- 10.1038/ng.2607
- PMCID
- PMC4106235
Common and rare variants associated with body mass index (BMI) and obesity account for <5% of the variance in BMI. We performed SNP and copy number variation (CNV) association analyses in 1,509 children with obesity at the extreme tail (>3 s.d. from the mean) of the BMI distribution and 5,380 controls. Evaluation of 29 SNPs (P < 1 Γ 10(-5)) in an additional 971 severely obese children and 1,990 controls identified 4 new loci associated with severe obesity (LEPR, PRKCH, PACS1 and RMST). A previously reported 43-kb deletion at the NEGR1 locus was significantly associated with severe obesity (P = 6.6 Γ 10(-7)). However, this signal was entirely driven by a flanking 8-kb deletion; absence of this deletion increased risk for obesity (P = 6.1 Γ 10(-11)). We found a significant burden of rare, single CNVs in severely obese cases (P < 0.0001). Integrative gene network pathway analysis of rare deletions indicated enrichment of genes affecting G protein-coupled receptors (GPCRs) involved in the neuronal regulation of energy homeostasis.
Genome wide SNP association study in severe early onset obesity. Manhattan plot showing the significance (βlog10(p)) of all SNPs in the discovery analysis. SNPs taken for replication (circled), established loci (dark grey) and novel loci (green) are shown. Horizontal dashed line indicates p=1Γ10β6.
Regional association plots of the novel loci generated using LocusZoom23.
A quantile-quantile plot of βlog10(p) of 481 common CNVs. Concentration band represents 95% confidence intervals. The data generally conform to the βlog10 transformed uniform distribution expected under the null hypothesis of no association, with the exception of strong associations with the two deletions upstream of NEGR1.
NEGR1 locus on chromosome 1p31.1. a. Schematic of the locus with the positions of the two deletions (8-kb and 43-kb) and neighbouring genes. b. Sequence conservation of the small 8-kb deletion sequence. Nucleotide Percent Identity Plot (PIP) for the region is shown. Orthologous sequences from multiple species were aligned to the human sequence using MultiPIP maker, and sequence identity >50% (light grey) and >75% (dark grey) is highlighted, with the details shown below. The predicted NKX6.1 binding site is located in the most conserved region (arrow). c. Transcription factor NKX6.1 binding was confirmed using EMSA assay, electromobility shift (arrow) was specific to the sequence contained in the 8-kb deletion. n/s (non-specific band).
1β19 of 19
| Name | Type |
|---|---|
| 1958BC local | cohort |
| 1958 British Birth Cohort | cohort |
| 8βkb deletion local | variant |
| affected status | phenotype |
| Affy6 SNPs local | variant |
| Affymetrix Human SNP Array 6.0 local | drug |
| Applied Biosystems | drug |
| BMI | phenotype |
| case cohort | cohort |
| cases | cohort |
| CEU | cohort |
| CHB+JPT | drug |
| CNV | variant |
| common CNVEs local | variant |
| control | cohort |
| controls | cohort |
| developmental delay | phenotype |
| early-onset obesity | phenotype |
| EPIC-Norfolk | cohort |
| EPIC-Obesity Study local | cohort |
| ethnic outliers local | phenotype |
| European population | cohort |
| Europeans | cohort |
| genetic distance local | phenotype |
| Genetics of Obesity Study local | cohort |
| GIH local | cohort |
| GOOS local | cohort |
| HBD burden local | phenotype |
| iPLEX Gold Assay local | drug |
| Light Shift Chemiluminescent EMSA Kit local | drug |
| MUT oligonucleotide local | drug |
| NEGR1 | gene |
| NEGR1 deletions local | variant |
| NKX6.1 local | gene |
| rare variant | cohort |
| rs17025867 local | variant |
| rs7255638 local | variant |
| SCOOP local | cohort |
| SCOOP cohort local | cohort |
| Sequenom | drug |
| SNP | cohort |
| TaqMan assay | drug |
| UK Blood Service Collection local | cohort |
| UKBS local | cohort |
| Wellcome Trust Case-Control Consortium local | cohort |
| Wellcome Trust Case Control Consortium 2 | cohort |
| WTCCC2 | cohort |
| WT oligonucleotide local | drug |
| WTSIby local | drug |
| YRI | cohort |
| Ξ±βNKX6.1 antibody local | drug |
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Childhood Obesity and Age-Related Diseases: A Systematic Review and Meta-Analysis of Mendelian Randomization Evidence. | Zhu H et al. | β | 2026 | β |
| PACS1 syndrome mutation disrupts dynein-mediated cargo transport via HDAC6 and BICD2. | Yang Y et al. | β | 2026 | β |
| Canine genome-wide association study identifies <i>DENND1B</i> as an obesity gene in dogs and humans. | Wallis NJ et al. | β | 2025 | β |
| Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning. | Mazzaferro E et al. | β | 2025 | β |
| Genetic Landscape of Obesity in Children: Research Advances and Prospects. | Khusainova R et al. | β | 2025 | β |
| Genetic pleiotropy underlying obesity and autoimmune disorders: a large-scale cross-trait gwas analysis in European ancestry populations. | Jiang X et al. | β | 2025 | β |
| Identification of gene-sex hormone interactions associated with type 2 diabetes among men and women. | Dabbs-Brown A et al. | β | 2025 | β |
| Integrative proteomic and lipidomic analysis of GNB1 and SCARB2 knockdown in human subcutaneous adipocytes. | Kitamoto T et al. | β | 2025 | β |
| Melanocortin-4 Receptor Gene Variants and Weight Change Following Switch to Integrase Inhibitor-Based Antiretroviral Therapy. | Hulgan T et al. | β | 2025 | β |
| Neuronal growth regulator 1 (NEGR1) promotes the synaptic targeting of glutamic acid decarboxylase 65 (GAD65). | Su F et al. | β | 2025 | β |
| Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk. | Zorn S et al. | β | 2025 | β |
| PACS deficiency disrupts Golgi architecture and causes cytokinesis failures and seizure-like phenotype in <i>Drosophila melanogaster</i>. | Frappaolo A et al. | β | 2025 | β |
| Sex-specific associations between body composition and depression among U.S. adults: a cross-sectional study. | Li Y et al. | β | 2025 | β |
| The Interplay of Genetic Predisposition, Circadian Misalignment, and Metabolic Regulation in Obesity. | Halder SK et al. | β | 2025 | β |
| Uncovering covariance patterns across energy balance traits enables the discovery of new obesity-related genes. | Gulisija D et al. | β | 2025 | β |
| Decoding the connection between lncRNA and obesity: Perspective from humans and <i>Drosophila</i>. | Dayal Aggarwal D et al. | β | 2024 | β |
| Detection of germline CNVs from gene panel data: benchmarking the state of the art. | MuntΓ© E et al. | β | 2024 | β |
| iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity. | Rylaarsdam L et al. | β | 2024 | β |
| Landscape of genomic structural variations in Indian population-based cohorts: Deeper insights into their prevalence and clinical relevance. | Subramanian K et al. | β | 2024 | β |
| Meta-analysis reveals obesity associated gut microbial alteration patterns and reproducible contributors of functional shift. | Chanda D et al. | β | 2024 | β |
| Rare copy-number variants as modulators of common disease susceptibility. | Auwerx C et al. | β | 2024 | β |
| Single-cell RNA-sequencing reveals a unique landscape of the tumor microenvironment in obesity-associated breast cancer. | Zhao G et al. | β | 2024 | β |
| COMMUTE: Communication-efficient transfer learning for multi-site risk prediction. | Gu T et al. | β | 2023 | β |
| Constructing a polygenic risk score for childhood obesity using functional data analysis. | Craig SJC et al. | β | 2023 | β |
| Development of genome-wide association studies on childhood obesity and its indicators: A scoping review and enrichment analysis. | Zhou F et al. | β | 2023 | β |
| Genetics and Epigenetics in Obesity: What Do We Know so Far? | Keller M et al. | β | 2023 | β |
| Human abdominal subcutaneous-derived active beige adipocytes carrying <i>FTO</i> rs1421085 obesity-risk alleles exert lower thermogenic capacity. | VΓ‘mos A et al. | β | 2023 | β |
| SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice. | Du X et al. | β | 2023 | β |
| Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases. | Huang C et al. | β | 2023 | β |
| The Impact of Bariatric Surgery on Quality of Life in Patients with Obesity. | Soroceanu RP et al. | β | 2023 | β |
| Cord blood leptin level and a common variant of its receptor as determinants of the BMI trajectory: The EDEN mother-child cohort. | CissΓ© AH et al. | β | 2022 | β |
| Depression-Associated <i>Negr1</i> Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to Amphetamine in Male Mice. | Kaare M et al. | β | 2022 | β |
| Genome-wide association study identifies genetic risk loci for adiposity in a Taiwanese population. | Wong HS et al. | β | 2022 | β |
| "GENYAL" Study to Childhood Obesity Prevention: Methodology and Preliminary Results. | Marcos-Pasero H et al. | β | 2022 | β |
| Influences of rare copy-number variation on human complex traits. | Hujoel MLA et al. | β | 2022 | β |
| Novel Noninvasive Approaches to the Treatment of Obesity: From Pharmacotherapy to Gene Therapy. | Angelidi AM et al. | β | 2022 | β |
| Peptides in the regulation of glucagon secretion. | Andersen DB et al. | β | 2022 | β |
| Rare Variant Analysis of Obesity-Associated Genes in Young Adults With Severe Obesity From a Consanguineous Population of Pakistan. | Saeed S et al. | β | 2022 | β |
| Targeted Exome Sequencing of Genes Involved in Rare CNVs in Early-Onset Severe Obesity. | Loid P et al. | β | 2022 | β |
| The genetics of obesity: from discovery to biology. | Loos RJF et al. | β | 2022 | β |
| The individual and global impact of copy-number variants on complex human traits. | Auwerx C et al. | β | 2022 | β |
| The role of FTO variant rs1421085 in the relationship with obesity: a systematic review and meta-analysis. | Najd-Hassan-Bonab L et al. | β | 2022 | β |
| Birth weight, childhood obesity and risk of hypertension: a Mendelian randomization study. | Fan J et al. | β | 2021 | β |
| Genetics of Obesity: What We Have Learned Over Decades of Research. | Bouchard C | β | 2021 | β |
| High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice. | Kaare M et al. | β | 2021 | β |
| Implications of germline copy-number variations in psychiatric disorders: review of large-scale genetic studies. | Nakatochi M et al. | β | 2021 | β |
| Old Paradoxes and New Opportunities for Appetite Control in Obesity. | MontΓ©gut L et al. | β | 2021 | β |
| Oxytocin: A Potential Therapeutic for Obesity. | Hong SM et al. | β | 2021 | β |
| Oxytocin, eating behavior, and metabolism in humans. | Kerem L et al. | β | 2021 | β |
| Robust Reductions of Body Weight and Food Intake by an Oxytocin Analog in Rats. | Elfers CT et al. | β | 2021 | β |
| The Potential Role of Exosomes in Child and Adolescent Obesity. | Maligianni I et al. | β | 2021 | β |
| 1p31.1 microdeletion including only NEGR1 gene in two patients. | Tassano E et al. | β | 2020 | β |
| A big-data approach to understanding metabolic rate and response to obesity in laboratory mice. | Corrigan JK et al. | β | 2020 | β |
| A Comprehensive Genome-Wide and Phenome-Wide Examination of BMI and Obesity in a Northern Nevadan Cohort. | Schlauch KA et al. | β | 2020 | β |
| CNV Association of Diverse Clinical Phenotypes from eMERGE reveals novel disease biology underlying cardiovascular disease. | Glessner JT et al. | β | 2020 | β |
| Contribution of Genetic Background and Data Collection on Adverse Events of Anti-human Immunodeficiency Virus (HIV) Drugs (D:A:D) Clinical Risk Score to Chronic Kidney Disease in Swiss HIV-infected Persons With Normal Baseline Estimated Glomerular Filtration Rate. | Dietrich LG et al. | β | 2020 | β |
| Depression in multiple sclerosis patients associated with risk variant near NEGR1. | Brugger SW et al. | β | 2020 | β |
| Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. | Marenne G et al. | β | 2020 | β |
| Genetic variation, adipokines, and cardiometabolic disease. | Metz S et al. | β | 2020 | β |
| Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study. | Eze IC et al. | β | 2020 | β |
| Heterozygous rare genetic variants in non-syndromic early-onset obesity. | Serra-JuhΓ© C et al. | β | 2020 | β |
| Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes. | Venkannagari H et al. | β | 2020 | β |
| Implication of genetic variants in overweight and obesity susceptibility among the young Arab population of the United Arab Emirates. | El Hajj Chehadeh S et al. | β | 2020 | β |
| Leptin-Mediated Changes in the Human Metabolome. | Lawler K et al. | β | 2020 | β |
| Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. | Erzurumluoglu AM et al. | β | 2020 | β |
| Metabolic Effects of Oxytocin. | McCormack SE et al. | β | 2020 | β |
| Mouse models for V103I and I251L gain of function variants of the human MC4R display decreased adiposity but are not protected against a hypercaloric diet. | Rojo D et al. | β | 2020 | β |
| Oxytocin in the neural control of eating: At the crossroad between homeostatic and non-homeostatic signals. | Romano A et al. | β | 2020 | β |
| Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children. | Breton E et al. | β | 2020 | β |
| Rare Variants in Genes Linked to Appetite Control and Hypothalamic Development in Early-Onset Severe Obesity. | Loid P et al. | β | 2020 | β |
| The expression of genes in top obesity-associated loci is enriched in insula and substantia nigra brain regions involved in addiction and reward. | Ndiaye FK et al. | β | 2020 | β |
| The role of epigenetics in the development of obesity. | Obri A et al. | β | 2020 | β |
| Association of <i>FTO</i> and <i>ADRB2</i> gene variation with energy restriction induced adaptations in resting energy expenditure and physical activity. | Camps SGJA et al. | β | 2019 | β |
| Benefits and limitations of genome-wide association studies. | Tam V et al. | β | 2019 | β |
| Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance. | Flores A et al. | β | 2019 | β |
| Depression and obesity: evidence of shared biological mechanisms. | Milaneschi Y et al. | β | 2019 | β |
| Established and emerging strategies to crack the genetic code of obesity. | Tam V et al. | β | 2019 | β |
| Genetic architecture of human thinness compared to severe obesity. | Riveros-McKay F et al. | β | 2019 | β |
| Genetic Basis of Obesity and Type 2 Diabetes in Africans: Impact on Precision Medicine. | Doumatey AP et al. | β | 2019 | β |
| Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth. | Helgeland Γ et al. | β | 2019 | β |
| GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI. | Couto Alves A et al. | β | 2019 | β |
| Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. | van der Klaauw AA et al. | β | 2019 | β |
| <i>FTO</i> Variant rs1421085 Associates With Increased Body Weight, Soft Lean Mass, and Total Body Water Through Interaction With Ghrelin and Apolipoproteins in Arab Population. | Hebbar P et al. | β | 2019 | β |
| Influence of validating the parental origin on the clinical interpretation of fetal copy number variations in 141 core family cases. | Shi P et al. | β | 2019 | β |
| Neuronal growth regulator 1-deficient mice show increased adiposity and decreased muscle mass. | Joo Y et al. | β | 2019 | β |
| Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. | Yang Y et al. | β | 2019 | β |
| The association of the common fat mass and obesity associated gene polymorphisms with type 2 diabetes in obese Iraqi population. | Nasser FA et al. | β | 2019 | β |
| The Homeodomain Transcription Factor NKX2.1 Is Essential for the Early Specification of Melanocortin Neuron Identity and Activates <i>Pomc</i> Expression in the Developing Hypothalamus. | Orquera DP et al. | β | 2019 | β |
| The role and possible mechanism of lncRNA AC092159.2 in modulating adipocyte differentiation. | Yuan Y et al. | β | 2019 | β |
| The STRONG Kids 2 Birth Cohort Study: A Cell-to-Society Approach to Dietary Habits and Weight Trajectories across the First 5 Years of Life. | Fiese BH et al. | β | 2019 | β |
| Advances in understanding the genetic basis of diabetic kidney disease. | Li M et al. | β | 2018 | β |
| A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci. | Hoffmann TJ et al. | β | 2018 | β |
| Analysis of the Impact of Common Polymorphisms of the FTO and MC4R Genes with the Risk of Severe Obesity in Saudi Arabian Population. | Cyrus C et al. | β | 2018 | β |
| Changes in Plasma Protein Expression Indicative of Early Diet-induced Metabolic Disease in Male Pigs (<i>Sus scrofa</i>). | Te Pas MF et al. | β | 2018 | β |
| Clinical significance of germline copy number variation in susceptibility of human diseases. | Hu L et al. | β | 2018 | β |
| Comprehensive review and annotation of susceptibility SNPs associated with obesity-related traits. | Dong SS et al. | β | 2018 | β |
| Copy Number Variation. | MacΓ© A et al. | β | 2018 | β |
| Gene expression profiling in adipose tissue of Sprague Dawley rats identifies olfactory receptor 984 as a potential obesity treatment target. | Giusepponi ME et al. | β | 2018 | β |
| Genes that make you fat, but keep you healthy. | Loos RJF et al. | β | 2018 | β |
| Genetics of Obesity in Consanguineous Populations: Toward Precision Medicine and the Discovery of Novel Obesity Genes. | Saeed S et al. | β | 2018 | β |
| Genetics of Severe Obesity. | Fairbrother U et al. | β | 2018 | β |
| Genome-wide burden and association analyses implicate copy number variations in asthma risk among children and young adults from Latin America. | Oliveira P et al. | β | 2018 | β |
| Genomic predictions combining SNP markers and copy number variations in Nellore cattle. | Hay EHA et al. | β | 2018 | β |
| Germline Duplication of SNORA18L5 Increases Risk for HBV-related Hepatocellular Carcinoma by Altering Localization of Ribosomal Proteins and Decreasing Levels of p53. | Cao P et al. | β | 2018 | β |
| Integrating CNVs into meta-QTL identified GBP4 as positional candidate for adult cattle stature. | Cao XK et al. | β | 2018 | β |
| Machine Learning-Based Method for Obesity Risk Evaluation Using Single-Nucleotide Polymorphisms Derived from Next-Generation Sequencing. | Wang HY et al. | β | 2018 | β |
| Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci. | Bell CG et al. | β | 2018 | β |
| Oxytocin and Eating Disorders: A Narrative Review on Emerging Findings and Perspectives. | Giel K et al. | β | 2018 | β |
| PheWAS and Beyond: The Landscape of Associations with Medical Diagnoses and Clinical Measures across 38,662 Individuals from Geisinger. | Verma A et al. | β | 2018 | β |
| Polymorphisms in Manganese Transporters <i>SLC30A1</i>0 and <i>SLC39A8</i> Are Associated With Children's Neurodevelopment by Influencing Manganese Homeostasis. | Wahlberg KE et al. | β | 2018 | β |
| ProxECAT: Proxy External Controls Association Test. A new case-control gene region association test using allele frequencies from public controls. | Hendricks AE et al. | β | 2018 | β |
| The Extending Spectrum of NPC1-Related Human Disorders: From Niemann-Pick C1 Disease to Obesity. | Lamri A et al. | β | 2018 | β |
| WaveDec: A Wavelet Approach to Identify Both Shared and Individual Patterns of Copy-Number Variations. | Cai H et al. | β | 2018 | β |
| Association between copy-number variation on metabolic phenotypes and HDL-C levels in patients with polycystic ovary syndrome. | Knebel B et al. | β | 2017 | β |
| Association Study of Three Gene Polymorphisms Recently Identified by a Genome-Wide Association Study with Obesity-Related Phenotypes in Chinese Children. | Song QY et al. | β | 2017 | β |
| Caught in the act - protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease. | Thomas G et al. | β | 2017 | β |
| CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. | MacΓ© A et al. | β | 2017 | β |
| Convergence between biological, behavioural and genetic determinants of obesity. | Ghosh S et al. | β | 2017 | β |
| Current findings on the role of oxytocin in the regulation of food intake. | Spetter MS et al. | β | 2017 | β |
| Epigenetic signatures of gestational diabetes mellitus on cord blood methylation. | Haertle L et al. | β | 2017 | β |
| Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation. | Lu Z et al. | β | 2017 | β |
| From genetics and epigenetics to the future of precision treatment for obesity. | Sun X et al. | β | 2017 | β |
| Genetic Predictors of β₯5% Weight Loss by Multidisciplinary Advice to Severely Obese Subjects. | Aller EEJG et al. | β | 2017 | β |
| Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depressive disorder | Wray NR et al. | β | 2017 | β |
| Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence. | Sniekers S et al. | β | 2017 | β |
| Genome-Wide Association of Copy Number Polymorphisms and Kidney Function. | Li M et al. | β | 2017 | β |
| Genomic complexity and targeted genes in anaplastic thyroid cancer cell lines. | Woodward EL et al. | β | 2017 | β |
| Identification of rs7350481 at chromosome 11q23.3 as a novel susceptibility locus for metabolic syndrome in Japanese individuals by an exome-wide association study. | Yamada Y et al. | β | 2017 | β |
| Leptin Receptor Gene Variant rs11804091 Is Associated with BMI and Insulin Resistance in Spanish Female Obese Children: A Case-Control Study. | Olza J et al. | β | 2017 | β |
| Molecular and functional genetics of the proopiomelanocortin gene, food intake regulation and obesity. | Rubinstein M et al. | β | 2017 | β |
| Novel genes involved in severe early-onset obesity revealed by rare copy number and sequence variants. | Serra-JuhΓ© C et al. | β | 2017 | β |
| Obesity in adults with 22q11.2 deletion syndrome. | Voll SL et al. | β | 2017 | β |
| Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity. | Hendricks AE et al. | β | 2017 | β |
| Structural variants caused by <i>Alu</i> insertions are associated with risks for many human diseases. | Payer LM et al. | β | 2017 | β |
| The effects of oxytocin on eating behaviour and metabolism in humans. | Lawson EA | β | 2017 | β |
| Validation of obesity susceptibility loci identified by genome-wide association studies in early childhood in South Brazilian children. | ZandonΓ‘ MR et al. | β | 2017 | β |
| Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits. | Tachmazidou I et al. | β | 2017 | β |
| A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP. | ΓaΔlayan AO et al. | β | 2016 | β |
| A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. | Ried JS et al. | β | 2016 | β |
| Association of genetic risk scores with body mass index in Swiss psychiatric cohorts. | Saigi-Morgui N et al. | β | 2016 | β |
| Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization. | Blevins JE et al. | β | 2016 | β |
| CNV analysis and mutation screening indicate an important role for the NPY4R gene in human obesity. | Aerts E et al. | β | 2016 | β |
| Copy number variation associates with mortality in long-lived individuals: a genome-wide assessment. | Nygaard M et al. | β | 2016 | β |
| Different Facets of Copy Number Changes: Permanent, Transient, and Adaptive. | Mishra S et al. | β | 2016 | β |
| Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome. | Kokosar M et al. | β | 2016 | β |
| Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits. | Polimanti R et al. | β | 2016 | β |
| Expression of candidate genes associated with obesity in peripheral white blood cells of Mexican children. | Ulloa-MartΓnez M et al. | β | 2016 | β |
| Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat. | Sung YJ et al. | β | 2016 | β |
| Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes. | Matsuo H et al. | β | 2016 | β |
| Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. | KilpelΓ€inen TO et al. | β | 2016 | β |
| Mechanisms of long noncoding RNA function in development and disease. | Schmitz SU et al. | β | 2016 | β |
| Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer. | Jarvis D et al. | β | 2016 | β |
| Multi-variant study of obesity risk genes in African Americans: The Jackson Heart Study. | Liu S et al. | β | 2016 | β |
| New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. | Lu Y et al. | β | 2016 | β |
| Practical Experience of the Application of a Weighted Burden Test to Whole Exome Sequence Data for Obesity and Schizophrenia. | Curtis D et al. | β | 2016 | β |
| Rare copy number variants and congenital heart defects in the 22q11.2 deletion syndrome. | Mlynarski EE et al. | β | 2016 | β |
| Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity. | Pigeyre M et al. | β | 2016 | β |
| Recurrent Rare Genomic Copy Number Variants and Bicuspid Aortic Valve Are Enriched in Early Onset Thoracic Aortic Aneurysms and Dissections. | Prakash S et al. | β | 2016 | β |
| Single nucleotide polymorphism-based microarray analysis for the diagnosis of hydatidiform moles. | Xie Y et al. | β | 2016 | β |
| Survival of the Curviest: Noise-Driven Selection for Synergistic Epistasis. | Wilkins JF et al. | β | 2016 | β |
| Tissue-Specific and Genetic Regulation of Insulin Sensitivity-Associated Transcripts in African Americans. | Sharma NK et al. | β | 2016 | β |
| Tumour biology of obesity-related cancers: understanding the molecular concept for better diagnosis and treatment. | Teoh SL et al. | β | 2016 | β |
| A Copy Number Variant on Chromosome 20q13.3 Implicated in Thinness and Severe Obesity. | Hasstedt SJ et al. | β | 2015 | β |
| A genome-wide association study of body mass index across early life and childhood. | Warrington NM et al. | β | 2015 | β |
| Association between the oxytocin receptor gene polymorphism (rs53576) and bulimia nervosa. | Kim YR et al. | β | 2015 | β |
| Association of the LINGO2-related SNP rs10968576 with body mass in a cohort of elderly Swedes. | Rask-Andersen M et al. | β | 2015 | β |
| Associations between TRPV4 genotypes and body mass index in Taiwanese subjects. | Duan DM et al. | β | 2015 | β |
| Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children. | MejΓa-BenΓtez MA et al. | β | 2015 | β |
| Childhood Obesity Is a Chronic Disease Demanding Specific Health Care--a Position Statement from the Childhood Obesity Task Force (COTF) of the European Association for the Study of Obesity (EASO). | Farpour-Lambert NJ et al. | β | 2015 | β |
| Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys. | Blevins JE et al. | β | 2015 | β |
| Clinical and Molecular Cytogenetic Characterization of a de novo Interstitial 1p31.1p31.3 Deletion in a Boy with Moderate Intellectual Disability and Severe Language Impairment. | Tassano E et al. | β | 2015 | β |
| Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals. | Nead KT et al. | β | 2015 | β |
| Differences in Common Genetic Predisposition to Ischemic Stroke by Age and Sex. | Traylor M et al. | β | 2015 | β |
| Differentiation of hypothalamic-like neurons from human pluripotent stem cells. | Wang L et al. | β | 2015 | β |
| Epigenetics of obesity: beyond the genome sequence. | Cordero P et al. | β | 2015 | β |
| Extreme obesity is associated with variation in genes related to the circadian rhythm of food intake and hypothalamic signaling. | Mariman EC et al. | β | 2015 | β |
| Genetics of human sleep behavioral phenotypes. | Hsu PK et al. | β | 2015 | β |
| Genome-wide association studies of human adiposity: Zooming in on synapses. | Sandholt CH et al. | β | 2015 | β |
| Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat. | Ollikainen M et al. | β | 2015 | β |
| Genome-wide genetic interaction analysis of glaucoma using expert knowledge derived from human phenotype networks. | Hu T et al. | β | 2015 | β |
| Impact of NEGR1 genetic variability on psychological traits of patients with eating disorders. | Gamero-Villarroel C et al. | β | 2015 | β |
| Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits. | Karaderi T et al. | β | 2015 | β |
| Interactions between obesity-related copy number variants and dietary behaviors in childhood obesity. | Zhang D et al. | β | 2015 | β |
| Involvement of Endogenous Enkephalins and Ξ²-Endorphin in Feeding and Diet-Induced Obesity. | Mendez IA et al. | β | 2015 | β |
| Kuwaiti population subgroup of nomadic Bedouin ancestry-Whole genome sequence and analysis. | John SE et al. | β | 2015 | β |
| [Monogenic and syndromic symptoms of morbid obesity. Rare but important]. | Wiegand S et al. | β | 2015 | β |
| Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity. | Apalasamy YD et al. | β | 2015 | β |
| Obesity genetics in mouse and human: back and forth, and back again. | Yazdi FT et al. | β | 2015 | β |
| Olfactory receptor genes cooperate with protocadherin genes in human extreme obesity. | Mariman EC et al. | β | 2015 | β |
| Pediatric obesity. An introduction. | Yanovski JA | β | 2015 | β |
| Recent Progress in the Understanding of Obesity: Contributions of Genome-Wide Association Studies. | Andersen MK et al. | β | 2015 | β |
| The development of youth-onset severe obesity in urban US girls. | McTigue KM et al. | β | 2015 | β |
| The ethnoepidemiology of obesity. | Valera B et al. | β | 2015 | β |
| The Genetics of Pediatric Obesity. | Chesi A et al. | β | 2015 | β |
| The hunger genes: pathways to obesity. | van der Klaauw AA et al. | β | 2015 | β |
| The UK10K project identifies rare variants in health and disease. | UK10K Consortium et al. | β | 2015 | β |
| Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans. | Blevins JE et al. | β | 2015 | β |
| Advances in exercise, fitness, and performance genomics in 2013. | Wolfarth B et al. | β | 2014 | β |
| A genome-wide association study identifies a LEPR gene as a novel predisposing factor for childhood fasting plasma glucose. | Go MJ et al. | β | 2014 | β |
| CANOES: detecting rare copy number variants from whole exome sequencing data. | Backenroth D et al. | β | 2014 | β |
| Copy number variants in Italian Large White pigs detected using high-density single nucleotide polymorphisms and their association with back fat thickness. | Schiavo G et al. | β | 2014 | β |
| Copy number variation in CCND1 gene is implicated in the pathogenesis of sporadic parathyroid carcinoma. | Zhao L et al. | β | 2014 | β |
| Copy Number Variation in Chickens: A Review and Future Prospects. | Wang X et al. | β | 2014 | β |
| Gene-based rare allele analysis identified a risk gene of Alzheimer's disease. | Kim JH et al. | β | 2014 | β |
| Genes and the hypothalamic control of metabolism in humans. | Hinney A et al. | β | 2014 | β |
| Genetic strategies to understand physiological pathways regulating body weight. | Farooqi S | β | 2014 | β |
| Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond. | Grarup N et al. | β | 2014 | β |
| Genome-wide analysis of copy number variation identifies candidate gene loci associated with the progression of non-alcoholic fatty liver disease. | Zain SM et al. | β | 2014 | β |
| Genomics, personalized medicine, and pediatrics. | Feero WG et al. | β | 2014 | β |
| High frequency of rare variants with a moderate-to-high predicted biological effect in protocadherin genes of extremely obese. | Mariman EC et al. | β | 2014 | β |
| Leptin mediates the increase in blood pressure associated with obesity. | Simonds SE et al. | β | 2014 | β |
| Novel LEPR mutations in obese Pakistani children identified by PCR-based enrichment and next generation sequencing. | Saeed S et al. | β | 2014 | β |
| Novel locus for fibrinogen in 3' region of LEPR gene in island population of Vis (Croatia). | Tomas Ε½ et al. | β | 2014 | β |
| Obesity and FTO: Changing Focus at a Complex Locus. | Tung YCL et al. | β | 2014 | β |
| Pharmacotherapy for obesity: novel agents and paradigms. | Manning S et al. | β | 2014 | β |
| Supraoptic oxytocin and vasopressin neurons function as glucose and metabolic sensors. | Song Z et al. | β | 2014 | β |
| The bigger picture of FTO: the first GWAS-identified obesity gene. | Loos RJ et al. | β | 2014 | β |
| The genetics of human obesity. | Waalen J | β | 2014 | β |
| The obesity-associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas. | Boender AJ et al. | β | 2014 | β |
| The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition. | Yeo GS | β | 2014 | β |
| Time to reappraise the use of body mass index in genetic association studies of children? | Franks PW | β | 2014 | β |
| Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery. | MΓ€gi R et al. | β | 2013 | β |
| Contribution of long noncoding RNAs to autism spectrum disorder risk. | Wilkinson B et al. | β | 2013 | β |
| Exon skipping and severe childhood-onset obesity caused by a leptin receptor mutation. | Kakar N et al. | β | 2013 | β |
| Future challenges and present ethical considerations in the use of personalized nutrition based on genetic advice. | San-Cristobal R et al. | β | 2013 | β |
| Genetic and epigenetic control of metabolic health. | Schwenk RW et al. | β | 2013 | β |
| Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia. | Khor CC et al. | β | 2013 | β |
| Individual genetic variations related to satiety and appetite control increase risk of obesity in preschool-age children in the STRONG kids program. | Wang Y et al. | β | 2013 | β |
| Mouse model implicates GNB3 duplication in a childhood obesity syndrome. | Goldlust IS et al. | β | 2013 | β |
| Role of oxytocin signaling in the regulation of body weight. | Blevins JE et al. | β | 2013 | β |