Chunk #7 — SNP Analysis — Imputation

Source

Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.

Embedded

yes

Text

After sample and SNP quality control, data was available for 1509 patients (333 with developmental delay) and 5380 controls from the 1958BC and UKBS collections used in WTCCC2 and up to 862,722 autosomal SNPs. These were separately imputed to the HapMap Phase 2 reference panel (release 22) in IMPUTE v1.0.026. After imputation, SNPs were excluded based on the same MAF, HWE & call-rate thresholds used prior to imputation.