Chunk #4 — SNP Analysis — Discovery genotyping and quality control

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Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.

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Genome-wide genotyping on 1386 patients from the SCOOP cohort was carried out using the Affymetrix Human SNP Array 6.0 chip at the Wellcome Trust Sanger Institute (WTSI). An additional 334 UK Caucasian GOOS samples described elsewhere20 previously genotyped using the Affymetrix Human SNP Array 6.0 chip at Aros, Inc. were re-called at the WTSI; both sets of cases were used in the discovery stage.