Heritability of age at menarche in girls from the Fels Longitudinal Study.
paper
Cited
Public
Unavailable
- Authors
- Towne, Bradford; Czerwinski, Stefan A; Demerath, Ellen W; Blangero, John; Roche, Alex F; Siervogel, Roger M
- Year
- 2005
- Journal
- American journal of physical anthropology
- PMID
- 15779076
- DOI
- 10.1002/ajpa.20106
Menarche is the hallmark maturational event of female childhood. Many studies indicated a significant genetic contribution to the timing of the onset of menstruation, but most of these studies were limited by the use of retrospective data and by the use of data from only certain types of relatives (i.e., mothers and daughters, sisters, or twin sisters). The primary goal of this study was to use a modern maximum likelihood quantitative genetic method to estimate the heritability (h(2)) of age at menarche, using familial data collected over the course of the 74-year-old Fels Longitudinal Study. The secondary goal was to review earlier studies of the heritability of age at menarche. The study of the heritability of age at menarche presented here is unique for two reasons. First, because of the Fels Longitudinal Study's serial design, age-at-menarche data were collected prospectively from most participants. Second, because the Fels Longitudinal Study is a family study that has been conducted for decades, age-at-menarche data are available from many types of female relatives spanning multiple households and generations. The best-fitting and most parsimonious quantitative genetic model included provision for a secular decrease in age at menarche, and estimated the h(2) of age at menarche to be 0.49+/- 0.13 (95% confidence interval of h(2),=0.24-0.73). The results of this study are in general agreement with the findings of most previous studies of genetic influences on age at menarche, and suggest that it is reasonable to consider it well-established that approximately half the phenotypic variation among girls from developed nations in the timing of menarche is due to genetic factors.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Association Between Age at Menarche and Cardiovascular Disease Among African American Women in the Jackson Heart Study. | Walker BH et al. | β | 2026 | β |
| Over the edge: Empirical evidence for the cliff-edge model of obstetric selection. | Watson LM et al. | β | 2026 | β |
| Age at Menarche and Coronary Artery Disease Risk: Divergent Associations With Different Sources of Variation. | Sonawalla A et al. | β | 2025 | β |
| A State of the Science Review of Human Health Effects of the Michigan Polybrominated Biphenyl Contamination after Five Decades. | Hoffman SS et al. | β | 2025 | β |
| Deleterious variants in intolerant genes reveal new candidates for self-limited delayed puberty. | Rezende RC et al. | β | 2025 | β |
| Performance of adult height prediction methods in 6 to 8-year-old girls with GnRH-dependent precocious puberty. | Erkko A et al. | β | 2025 | β |
| Polycystic Ovary Syndrome and the Risk of Premenstrual Disorders: A Nationwide Register-Based Study in Sweden. | Opatowski M et al. | β | 2025 | β |
| Association between dietary behavior and puberty in girls. | Du Y et al. | β | 2024 | β |
| Association of blood metal exposure with age at menarche in Korean women: KNHANES (2008-2017). | Park S et al. | β | 2024 | β |
| Epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset. | Kim C et al. | β | 2024 | β |
| Improving menstrual health knowledge among girls from Iran: the effectiveness of educational health belief model. | Yari A et al. | β | 2024 | β |
| Reproductive risk factors across the female lifecourse and later metabolic health. | Nichols AR et al. | β | 2024 | β |
| Self-reported history of breastfeeding in relation to recalled age at menarche in the United States. | Gold CL et al. | β | 2024 | β |
| The genetic architecture of age at menarche and its causal effects on other traits. | Feng GJ et al. | β | 2024 | β |
| Age at menarche and its association with blood pressure in adult women of developing countries: a systematic review and meta-analysis. | Wang G et al. | β | 2023 | β |
| Between group heritability and the status of hereditarianism as an evolutionary science | Roseman CC et al. | β | 2023 | β |
| Early Life Environmental Exposure to Cadmium, Lead, and Arsenic and Age at Menarche: A Longitudinal Mother-Child Cohort Study in Bangladesh. | Malin Igra A et al. | β | 2023 | β |
| Analysis of the Timing of Puberty in a Recent Cohort of Italian Girls: Evidence for Earlier Onset Compared to Previous Studies. | Ferrari V et al. | β | 2022 | β |
| Development of precocious puberty in children: Surmised medicinal plant treatment. | Han XX et al. | β | 2022 | β |
| Effects of Elevated Maternal Adiposity on Offspring Reproductive Health: A Perspective From Epidemiologic Studies. | Cinzori ME et al. | β | 2022 | β |
| Genetics of pubertal delay. | Saengkaew T et al. | β | 2022 | β |
| Increased Incidence of Precocious Puberty in Girls During COVID-19 Pandemic: Early Indicator of the Upcoming Childhood Metabolic Syndrome Pandemic? | Itani A et al. | β | 2022 | β |
| The influence of harshness and unpredictability on female sexual development: Addressing gene-environment interplay using a polygenic score. | Schlomer GL et al. | β | 2022 | β |
| Age at menarche in Nigerian demographic surveys. | Garenne M | β | 2021 | β |
| A secular trend in age at menarche in Yunnan Province, China: a multiethnic population study of 1,275,000 women. | Liu W et al. | β | 2021 | β |
| Genetic Regulation of Physiological Reproductive Lifespan and Female Fertility. | McGrath IM et al. | β | 2021 | β |
| Medieval menarche: Changes in pubertal timing before and after the Black Death. | DeWitte SN et al. | β | 2021 | β |
| A Systematic Literature Review of Factors Affecting the Timing of Menarche: The Potential for Climate Change to Impact Women's Health. | CanelΓ³n SP et al. | β | 2020 | β |
| Biological aging in childhood and adolescence following experiences of threat and deprivation: A systematic review and meta-analysis. | Colich NL et al. | β | 2020 | β |
| Child-related and parental predictors for thelarche in a general population of girls: the PANIC study. | Savinainen SE et al. | β | 2020 | β |
| Delayed and Precocious Puberty: Genetic Underpinnings and Treatments. | Gohil A et al. | β | 2020 | β |
| Earlier age at menarche as a transdiagnostic mechanism linking childhood trauma with multiple forms of psychopathology in adolescent girls. | Colich NL et al. | β | 2020 | β |
| Early age at menarche and its associated factors in school girls (age, 10 to 12βyears) in Bangladesh: a cross-section survey in Rajshahi District, Bangladesh. | Malitha JM et al. | β | 2020 | β |
| Life History Transitions at the Origins of Agriculture: A Model for Understanding How Niche Construction Impacts Human Growth, Demography and Health. | Wells JCK et al. | β | 2020 | β |
| The levelling-off of the secular trend of age at menarche among Italian girls. | Piras GN et al. | β | 2020 | β |
| Heritability of Age at Menarche in South Korean Female Twins. | Hur YM et al. | β | 2019 | β |
| Links between age at menarche, antral follicle count, and body mass index in African American and European American women. | Schuh SM et al. | β | 2019 | β |
| Parents of early-maturing girls die younger. | HΓ΅rak P et al. | β | 2019 | β |
| Association of prenatal and childhood environment smoking exposure with puberty timing: a systematic review and meta-analysis. | Chen Y et al. | β | 2018 | β |
| Associations Between Maternal Prepregnancy Body Mass Index and Gestational Weight Gain and Daughter's Age at Menarche: The Avon Longitudinal Study of Parents and Children. | Lawn RB et al. | β | 2018 | β |
| Father Absence and Accelerated Reproductive Development in Non-Hispanic White Women in the United States. | Gaydosh L et al. | β | 2018 | β |
| Genetics of pubertal timing. | Zhu J et al. | β | 2018 | β |
| Is age of menarche related to urinary symptoms in young Jordanian girls? A prospective cross-sectional study. | Al-Mehaisen LMM et al. | β | 2018 | β |
| The tempo of human childhood: a maternal foot on the accelerator, a paternal foot on the brake. | Kotler J et al. | β | 2018 | β |
| Weight Management Behaviors Among Mexican American Youth: Cross-Sectional Variation by Timing of Growth and Maturation. | Gay JL et al. | β | 2018 | β |
| Dairy intake in relation to breast and pubertal development in Chilean girls. | Gaskins AJ et al. | β | 2017 | β |
| Gene expression profiling of puberty-associated genes reveals abundant tissue and sex-specific changes across postnatal development. | Hou H et al. | β | 2017 | β |
| Genetic Polymorphism of NUCKS1 Is Associated With the Susceptibility of Adolescent Idiopathic Scoliosis. | Xu L et al. | β | 2017 | β |
| Genetic variations, reproductive aging, and breast cancer risk in African American and European American women: The Women's Circle of Health Study. | Coignet MV et al. | β | 2017 | β |
| Race disparities in pubertal timing: Implications for cardiovascular disease risk among African American women. | Bleil ME et al. | β | 2017 | β |
| Relationship between pubertal timing and chronic nonspecific pain in adolescent girls: the Young-HUNT3 study (2006-2008). | KlΓΈven B et al. | β | 2017 | β |
| Relationships Between Age at Menarche, Walking Gait Base of Support, and Stance Phase Frontal Plane Knee Biomechanics in Adolescent Girls. | Froehle AW et al. | β | 2017 | β |
| The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP). | Leka-Emiri S et al. | β | 2017 | β |
| Age at menarche and its association with the metabolic syndrome in Taiwan. | Chang CJ et al. | β | 2016 | β |
| Age at menarche and the risk of diabetic microvascular complications in patients with type 1 diabetes. | Harjutsalo V et al. | β | 2016 | β |
| Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data. | Shi H et al. | β | 2016 | β |
| Familial early puberty: presentation and inheritance pattern in 139 families. | Durand A et al. | β | 2016 | β |
| Infection and pubertal timing: a systematic review. | McDonald JA et al. | β | 2016 | β |
| Maternal Pre-pregnancy BMI and Reproductive Health of Daughters in Young Adulthood. | Mariansdatter SE et al. | β | 2016 | β |
| What does the mean menarcheal age mean?-An analysis of temporal pattern in variability in a historical swiss population from the 19th and 20th centuries. | Lehmann A et al. | β | 2016 | β |
| Association of breast cancer-related microRNA polymorphisms with idiopathic primary ovarian insufficiency. | Rah H et al. | β | 2015 | β |
| Associations between menarche-related genetic variants and pubertal growth in male and female adolescents. | Tu W et al. | β | 2015 | β |
| Childhood Passive Smoking Exposure and Age at Menarche in Chinese Women Who Had Never Smoked: The Guangzhou Biobank Cohort Study. | Yang S et al. | β | 2015 | β |
| Earlier menarcheal age in Spanish girls is related with an increase in body mass index between pre-pubertal school age and adolescence. | Gavela-PΓ©rez T et al. | β | 2015 | β |
| Is it all determined at menarche? | Schnabel RB | β | 2015 | β |
| Low mineral density of a weight-bearing bone among adult women in a high fertility population. | Stieglitz J et al. | β | 2015 | β |
| Metabolic Syndrome and Menopause: Pathophysiology, Clinical and Diagnostic Significance. | Stefanska A et al. | β | 2015 | β |
| Association of inhibin Ξ± gene promoter polymorphisms with risk of idiopathic primary ovarian insufficiency in Korean women. | Rah H et al. | β | 2014 | β |
| Child maltreatment and household dysfunction: associations with pubertal development in a British birth cohort. | Li L et al. | β | 2014 | β |
| Estrogen receptors genes polymorphisms and age at menarche in idiopathic scoliosis. | Janusz P et al. | β | 2014 | β |
| Genome-wide association studies of age at menarche and age at natural menopause. | He C et al. | β | 2014 | β |
| Interrelations between anthropometric and fitness changes during mid-adolescence in boys: a 2-year longitudinal study. | Gerber BP et al. | β | 2014 | β |
| Pubertal timing, bone acquisition, and risk of fracture throughout life. | Bonjour JP et al. | β | 2014 | β |
| Secular trends in age at menarche among women born between 1955 and 1985 in Southeastern China. | Lyu Y et al. | β | 2014 | β |
| What can we learn from twin studies? A comprehensive evaluation of the equal environments assumption. | Felson J | β | 2014 | β |
| Age at menarche and age at first sexual intercourse: a prospective cohort study. | Marino JL et al. | β | 2013 | β |
| FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimΓΌllerian hormone in healthy girls: a longitudinal cohort study. | Hagen CP et al. | β | 2013 | β |
| Genetic and environmental effects on age at menarche, and its relationship with reproductive health in twins. | Jahanfar S et al. | β | 2013 | β |
| Genetic risk for earlier menarche also influences peripubertal body mass index. | Johnson W et al. | β | 2013 | β |
| Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study. | Spencer KL et al. | β | 2013 | β |
| Gene x environment interactions impact endometrial function and the menstrual cycle: PROGINS, life history, anthropometry, and physical activity. | Rowe EJ et al. | β | 2013 | β |
| Genome-wide association study of age at menarche in African-American women. | Demerath EW et al. | β | 2013 | β |
| Genome wide association study of age at menarche in the Japanese population. | Tanikawa C et al. | β | 2013 | β |
| Influences on the onset and tempo of puberty in human beings and implications for adolescent psychological development. | Lee Y et al. | β | 2013 | β |
| Intake of dairy products, calcium, magnesium, and phosphorus in childhood and age at menarche in the Tehran Lipid and Glucose Study. | Ramezani Tehrani F et al. | β | 2013 | β |
| Investigation of peripubertal expression of Lin28a and Lin28b in C57BL/6 female mice. | Grieco A et al. | β | 2013 | β |
| Life-course origins of the ages at menarche and menopause. | Forman MR et al. | β | 2013 | β |
| Replication of LIN28B SNP association with age of menarche in young Filipino women. | Croteau-Chonka DC et al. | β | 2013 | β |
| Social and emotional predictors of the tempo of puberty in female rhesus monkeys. | Wilson ME et al. | β | 2013 | β |
| Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. | Zaitlen N et al. | β | 2013 | β |
| Association of methylenetetrahydrofolate reductase (MTHFR 677C>T) and thymidylate synthase (TSER and TS 1494del6) polymorphisms with premature ovarian failure in Korean women. | Rah H et al. | β | 2012 | β |
| Determinants of age at menarche and time to menstrual cycle regularity in the French E3N cohort. | Dossus L et al. | β | 2012 | β |
| DNA polymorphisms of the KiSS1 3' untranslated region interfere with the folding of a G-rich sequence into G-quadruplex. | Huijbregts L et al. | β | 2012 | β |
| Early menarche as an alternative reproductive tactic in human females: an evolutionary approach to reproductive health issues. | Gillette MT et al. | β | 2012 | β |
| Inter-generational influences on age at onset of puberty: Hong Kong's 'Children of 1997' birth cohort. | Hui LL et al. | β | 2012 | β |
| Pubertal Timing as a Potential Mediator of Adoption Effects on Problem Behaviors. | Brooker RJ et al. | β | 2012 | β |
| Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study. | Chen CT et al. | β | 2012 | β |
| Reproductive factors and serum uric acid levels in females from the general population: the KORA F4 study. | StΓΆckl D et al. | β | 2012 | β |
| Testing predictions of the programmed and stochastic theories of aging: comparison of variation in age at death, menopause, and sexual maturation. | Gavrilova NS et al. | β | 2012 | β |
| The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals. | Murabito JM et al. | β | 2012 | β |
| Age at menarche and its association with the metabolic syndrome and its components: results from the KORA F4 study. | StΓΆckl D et al. | β | 2011 | β |
| Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study. | Murray A et al. | β | 2011 | β |
| Early life infections and onset of puberty: evidence from Hong Kong's children of 1997 birth cohort. | Kwok MK et al. | β | 2011 | β |
| Evidence for evolution in response to natural selection in a contemporary human population. | Milot E et al. | β | 2011 | β |
| Familial concordance for age at menarche: analyses from the Breakthrough Generations Study. | Morris DH et al. | β | 2011 | β |
| Familial concordance for age at natural menopause: results from the Breakthrough Generations Study. | Morris DH et al. | β | 2011 | β |
| Pubertal development moderates the importance of environmental influences on depressive symptoms in adolescent girls and boys. | Edwards AC et al. | β | 2011 | β |
| Re-examining heritability: genetics, life history and plasticity. | Wells JC et al. | β | 2011 | β |
| Reported early family environment covaries with menarcheal age as a function of polymorphic variation in estrogen receptor-Ξ±. | Manuck SB et al. | β | 2011 | β |
| Secular trends in age at menarche in women in the UK born 1908-93: results from the Breakthrough Generations Study. | Morris DH et al. | β | 2011 | β |
| Social and developmental influences on urinary androgen levels in young male white-faced marmosets (Callithrix geoffroyi). | Birnie AK et al. | β | 2011 | β |
| Vitamin D deficiency and age at menarche: a prospective study. | Villamor E et al. | β | 2011 | β |
| Age at menarche in a Korean population: secular trends and influencing factors. | Cho GJ et al. | β | 2010 | β |
| Associations of progesterone receptor polymorphisms with age at menarche and menstrual cycle length. | Taylor KC et al. | β | 2010 | β |
| Determinants of age at menarche in the UK: analyses from the Breakthrough Generations Study. | Morris DH et al. | β | 2010 | β |
| Determinants of menarche. | Karapanou O et al. | β | 2010 | β |
| Genetic determinants of pubertal timing in the general population. | Gajdos ZK et al. | β | 2010 | β |
| Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty. | Mouritsen A et al. | β | 2010 | β |
| Role of prenatal characteristics and early growth on pubertal attainment of British girls. | Maisonet M et al. | β | 2010 | β |
| The (TTTA)n polymorphism of aromatase (CYP19) gene is associated with age at menarche. | Xita N et al. | β | 2010 | β |
| Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. | Elks CE et al. | β | 2010 | β |
| Developing a risk-model of time to first-relapse for children and adolescents with a psychotic disorder. | Gearing RE et al. | β | 2009 | β |
| Early life circumstances and their impact on menarche and menopause. | Mishra GD et al. | β | 2009 | β |
| Fitness-related patterns of genetic variation in rhesus macaques. | Blomquist GE | β | 2009 | β |
| Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche. | Sulem P et al. | β | 2009 | β |
| Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. | Perry JR et al. | β | 2009 | β |
| Timing of maturation and predictors of menarche in girls enrolled in a contemporary British cohort. | Rubin C et al. | β | 2009 | β |
| What controls the timing of puberty? An update on progress from genetic investigation. | Gajdos ZK et al. | β | 2009 | β |
| Age at menarche in contemporary Greek girls: evidence for levelling-off of the secular trend. | Papadimitriou A et al. | β | 2008 | β |
| A genome-wide linkage scan for age at menarche in three populations of European descent. | Anderson CA et al. | β | 2008 | β |
| Association studies of common variants in 10 hypogonadotropic hypogonadism genes with age at menarche. | Gajdos ZK et al. | β | 2008 | β |
| Chromosomal regions 22q13 and 3p25 may harbor quantitative trait loci influencing both age at menarche and bone mineral density. | Pan F et al. | β | 2008 | β |
| Early sexual maturity among PumΓ© foragers of Venezuela: fitness implications of teen motherhood. | Kramer KL | β | 2008 | β |
| Genetic control of pubertal timing. | Kaminski BA et al. | β | 2008 | β |
| Genome-wide identification of QTL for age at puberty in gilts using a large intercross F2 population between White Duroc x Erhualian. | Yang G et al. | β | 2008 | β |
| Menstruation in adolescents: what's normal, what's not. | Adams Hillard PJ | β | 2008 | β |
| Timing of menarche, childbearing and hysterectomy risk. | Cooper R et al. | β | 2008 | β |
| Estimation of variance components for age at menarche in twin families. | Anderson CA et al. | β | 2007 | β |
| Hypoplastic left heart syndrome is heritable. | Hinton RB et al. | β | 2007 | β |
| The familial clustering of age at menarche in extended twin families. | van den Berg SM et al. | β | 2007 | β |
| Variability of reproductive history across the Swiss SAPALDIA cohort--patterns and main determinants. | Dratva J et al. | β | 2007 | β |
| Changing times: the evolution of puberty. | Gluckman PD et al. | β | 2006 | β |
| Evolution, development and timing of puberty. | Gluckman PD et al. | β | 2006 | β |
| Genetic and environmental correlations between obesity phenotypes and age at menarche. | Wang W et al. | β | 2006 | β |
| Genetics of osteoporosis. | Obermayer-Pietsch B | β | 2006 | β |
| Opposing influences of prenatal and postnatal growth on the timing of menarche. | Tam CS et al. | β | 2006 | β |
| Obstetric outcomes of adolescent pregnancies in Turkey. | Canbaz S et al. | β | 2005 | β |