The two most significant loci for age at menarche confirmed the previously reported associations at LIN28B (rs7759938; P=1.6×10−58) and 9q31.2 (rs2090409; P=4.4×10−33) (Table 1; Supplementary Fig. 3). In addition, there were genome-wide significant signals for a further 40 possible novel loci, of which 30 survived a second more stringent correction for the overall genomic control in the Stage 1 cohorts (λ=1.173) (Table 1; Fig. 1; Supplementary Fig. 3).
