Inhibins in childhood and puberty.
- Authors
- Raivio, Taneli; Dunkel, Leo
- Year
- 2002
- Journal
- Best practice & research. Clinical endocrinology & metabolism
- PMID
- 11987897
- DOI
- 10.1053/beem.2001.0179
Inhibin is a heterodimeric glycoprotein that consists of an alpha-subunit linked to either a betaA subunit (inhibin A) or to a betaB subunit (inhibin B) and it exists in at least six different isoforms. These isoforms can not be measured separately by immunoassays. In boys, serum inhibin B levels change in concert with the increase in gonadotrophins. Associated with the postnatal activation of gonadotrophin secretion, the early inhibin B secretion is sustained until the age of 18-24 months; thereafter serum concentrations subside. In boys, between Tanner stages G1 and G2, serum inhibin B concentration again increases, but then plateaus. Inhibin A levels in human males are below the detection limit, but in girls, during the postnatal activation of gonadotrophin secretion, both serum inhibin A and inhibin B concentrations are measurable. Serum inhibin B levels correlate positively with age several years before the clinical onset of puberty, suggesting increasing follicular activity in late prepuberty. During female puberty, the inhibin B level increases from Tanner stage B1 through stage B3, suggesting high follicular activity before the development of ovulatory menstrual cycles, but serum inhibin A levels become measurable later in puberty, in agreement with the idea that inhibin A is mainly produced by the corpus luteum.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Association of exposure to synthetic phenols and metal(loid)s with early puberty in Spanish girls: a multicentric case-control study. | Olivas-Martinez A et al. | β | 2026 | β |
| Protective effect of alpha-tocopherol succinate on AlβOβ-NPs induced damage in NMRI mice Sertoli cells: the role of inhibin B and Connexin 43. | Naki MD et al. | β | 2026 | β |
| Basal and Stimulated Inhibin B in Pubertal Disorders. | Chaudhary S et al. | β | 2025 | β |
| Late toxicity comparison of alkylating-based maintenance regimen with cyclophosphamide (VAC) vs ifosfamide (VAI) in Ewing sarcoma survivors treated in the randomized clinical trial Euro-EWING99-R1 in France. | Corvest V et al. | β | 2023 | β |
| Standardizing the surgical management of benign ovarian tumors in children and adolescents: A best practice Delphi consensus statement. | Braungart S et al. | β | 2022 | β |
| Unravelling a novel, promising and convenient tool for differential diagnosis of delayed puberty: GnRHa-stimulated inhibin B (GnRH-iB). | Chaudhary S et al. | β | 2022 | β |
| Immature Follicular Origins and Disrupted Oocyte Growth Pathways Contribute to Decreased Gamete Quality During Reproductive Juvenescence in Mice. | Kusuhara A et al. | β | 2021 | β |
| Diagnostic value of pituitary volume in girls with precocious puberty. | Wu S et al. | β | 2020 | β |
| Diagnostic Value of Pituitary Volume in Girls with Precocious Puberty | Wu S et al. | β | 2020 | β |
| Puberty and Inhibin B in 35 Adolescents With Pituitary Stalk Interruption Syndrome. | Corvest V et al. | β | 2020 | β |
| Primary gonadal failure. | Ladjouze A et al. | β | 2019 | β |
| Thyroid dysfunction and hepatic steatosis in overweight children and adolescents. | Kaltenbach TE et al. | β | 2017 | β |
| Relative levels of the proprotein and cleavage-activated form of circulating human anti-MΓΌllerian hormone are sexually dimorphic and variable during the life cycle. | Pankhurst MW et al. | β | 2016 | β |
| [Therapeutic issues concerning male fertility]. | Bernard V et al. | β | 2014 | β |
| Baseline inhibin B levels for diagnosis of central precocious puberty in girls. | De Filippo G et al. | β | 2013 | β |
| Gene-environment interactions: the potential role of contaminants in somatic growth and the development of the reproductive system of the American alligator. | Moore BC et al. | β | 2012 | β |
| Inhibin B and luteinizing hormone levels in girls aged 6-11 years from NHANES III, 1988-1994. | Sims EK et al. | β | 2012 | β |
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| Altered gonadal expression of TGF-Ξ² superfamily signaling factors in environmental contaminant-exposed juvenile alligators. | Moore BC et al. | β | 2011 | β |
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| Gonadal mRNA expression levels of TGFbeta superfamily signaling factors correspond with post-hatching morphological development in American alligators. | Moore BC et al. | β | 2010 | β |
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| Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. | Elks CE et al. | β | 2010 | β |
| Effect of scrotal incision orchiopexy on serum inhibin B levels and comparison with classic inguinal orchiopexy. | Irkilata HC et al. | β | 2008 | β |
| Inhibin B levels in peripheral vein do not correlate with inhibin B levels in the spermatic vein in adolescents with varicocele. | TΓΌrkyilmaz Z et al. | β | 2006 | β |
| Inhibins in female and male reproductive physiology: role in gametogenesis, conception, implantation and early pregnancy. | Luisi S et al. | β | 2005 | β |
| Biomarkers for assessing reproductive development and health: Part 1--Pubertal development. | Rockett JC et al. | β | 2004 | β |
| GnRH agonist stimulation of the pituitary-gonadal axis in children: age and sex differences in circulating inhibin-B and activin-A. | Elsholz DD et al. | β | 2004 | β |
| Inhibin B: a novel marker of spermatogenesis. | Pierik FH et al. | β | 2003 | β |
| Update on female pubertal development. | Apter D et al. | β | 2002 | β |