Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

paper Primary Public

Authors: Perry, John Rb; Day, Felix; Elks, Cathy E; Sulem, Patrick; Thompson, Deborah J; Ferreira, Teresa; He, Chunyan; Chasman, Daniel I; Esko, Tõnu; Thorleifsson, Gudmar; Albrecht, Eva; Ang, Wei Q; Corre, Tanguy; Cousminer, Diana L; Feenstra, Bjarke; Franceschini, Nora; Ganna, Andrea; Johnson, Andrew D; Kjellqvist, Sanela; Lunetta, Kathryn L; McMahon, George; Nolte, Ilja M; Paternoster, Lavinia; Porcu, Eleonora; Smith, Albert V; Stolk, Lisette; Teumer, Alexander; Tšernikova, Natalia; Tikkanen, Emmi; Ulivi, Sheila; Wagner, Erin K; Amin, Najaf; Bierut, Laura J; Byrne, Enda M; Hottenga, Jouke-Jan; Koller, Daniel L; Mangino, Massimo; Pers, Tune H; Yerges-Armstrong, Laura M; Zhao, Jing Hua; Andrulis, Irene L; Anton-Culver, Hoda; Atsma, Femke; Bandinelli, Stefania; Beckmann, Matthias W; Benitez, Javier; Blomqvist, Carl; Bojesen, Stig E; Bolla, Manjeet K; Bonanni, Bernardo; Brauch, Hiltrud; Brenner, Hermann; Buring, Julie E; Chang-Claude, Jenny; Chanock, Stephen; Chen, Jinhui; Chenevix-Trench, Georgia; Collée, J Margriet; Couch, Fergus J; Couper, David; Coveillo, Andrea D; Cox, Angela; Czene, Kamila; D'adamo, Adamo Pio; Smith, George Davey; De Vivo, Immaculata; Demerath, Ellen W; Dennis, Joe; Devilee, Peter; Dieffenbach, Aida K; Dunning, Alison M; Eiriksdottir, Gudny; Eriksson, Johan G; Fasching, Peter A; Ferrucci, Luigi; Flesch-Janys, Dieter; Flyger, Henrik; Foroud, Tatiana; Franke, Lude; Garcia, Melissa E; García-Closas, Montserrat; Geller, Frank; de Geus, Eco Ej; Giles, Graham G; Gudbjartsson, Daniel F; Gudnason, Vilmundur; Guénel, Pascal; Guo, Suiqun; Hall, Per; Hamann, Ute; Haring, Robin; Hartman, Catharina A; Heath, Andrew C; Hofman, Albert; Hooning, Maartje J; Hopper, John L; Hu, Frank B; Hunter, David J; Karasik, David; Kiel, Douglas P; Knight, Julia A; Kosma, Veli-Matti; Kutalik, Zoltan; Lai, Sandra; Lambrechts, Diether; Lindblom, Annika; Mägi, Reedik; Magnusson, Patrik K; Mannermaa, Arto; Martin, Nicholas G; Masson, Gisli; McArdle, Patrick F; McArdle, Wendy L; Melbye, Mads; Michailidou, Kyriaki; Mihailov, Evelin; Milani, Lili; Milne, Roger L; Nevanlinna, Heli; Neven, Patrick; Nohr, Ellen A; Oldehinkel, Albertine J; Oostra, Ben A; Palotie, Aarno; Peacock, Munro; Pedersen, Nancy L; Peterlongo, Paolo; Peto, Julian; Pharoah, Paul Dp; Postma, Dirkje S; Pouta, Anneli; Pylkäs, Katri; Radice, Paolo; Ring, Susan; Rivadeneira, Fernando; Robino, Antonietta; Rose, Lynda M; Rudolph, Anja; Salomaa, Veikko; Sanna, Serena; Schlessinger, David; Schmidt, Marjanka K; Southey, Mellissa C; Sovio, Ulla; Stampfer, Meir J; Stöckl, Doris; Storniolo, Anna M; Timpson, Nicholas J; Tyrer, Jonathan; Visser, Jenny A; Vollenweider, Peter; Völzke, Henry; Waeber, Gerard; Waldenberger, Melanie; Wallaschofski, Henri; Wang, Qin; Willemsen, Gonneke; Winqvist, Robert; Wolffenbuttel, Bruce Hr; Wright, Margaret J; Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines Cohort Study; InterAct Consortium; Early Growth Genetics (EGG) Consortium; Boomsma, Dorret I; Econs, Michael J; Khaw, Kay-Tee; Loos, Ruth Jf; McCarthy, Mark I; Montgomery, Grant W; Rice, John P; Streeten, Elizabeth A; Thorsteinsdottir, Unnur; van Duijn, Cornelia M; Alizadeh, Behrooz Z; Bergmann, Sven; Boerwinkle, Eric; Boyd, Heather A; Crisponi, Laura; Gasparini, Paolo; Gieger, Christian; Harris, Tamara B; Ingelsson, Erik; Järvelin, Marjo-Riitta; Kraft, Peter; Lawlor, Debbie; Metspalu, Andres; Pennell, Craig E; Ridker, Paul M; Snieder, Harold; Sørensen, Thorkild Ia; Spector, Tim D; Strachan, David P; Uitterlinden, André G; Wareham, Nicholas J; Widen, Elisabeth; Zygmunt, Marek; Murray, Anna; Easton, Douglas F; Stefansson, Kari; Murabito, Joanne M; Ong, Ken K
Year: 2014
Journal: Nature
PMID: 25231870
DOI: 10.1038/nature13545
PMCID: PMC4185210

Figure 1

Manhattan and QQ plot of the GWAS for age at menarcheManhattan (main panel) and quantile-quantile (QQ) (embedded) plots illustrating results of the genome-wide association study (GWAS) meta-analysis for age at menarche in up to 182,416 women of European descent. The Manhattan plot presents the association -log10 P-values for each genome-wide SNP (Y-axis) by chromosomal position (X-axis). The red line indicates the threshold for genome-wide statistical significance (P=5×10−8). Blue dots represent SNPs whose nearest gene is the same as that of the genome-wide significant signals. The QQ plot illustrates the deviation of association test statistics (blue dots) from the distribution expected under the null hypothesis (red line).

Figure 2

Forest plot of parent-of-origin specific allelic associations at three imprinted menarche lociThe forest plot illustrates the associations of variants in four independent genomic signals for age at menarche that are located in three imprinted gene regions. For each variant, squares (and error bars) indicate the estimated per-allele effect sizes on age at menarche in years (and 95% confidence intervals) from the standard additive models in the combined ReproGen meta-analysis (Black), and separately for the paternally-inherited (Blue) or maternally-inherited allele (Red) in up to 35,377 women from the deCODE study. The association for the menarche locus with the largest effect size at LIN28B is also shown for reference, illustrating the similar magnitude of effect size at the MKRN3 locus when parent-of-origin is taken into account.

Figure 3

Schematic diagram indicating possible roles in the hypothalamic-pituitary-ovarian axis of several of the implicated genes and biological mechanisms for menarche timing

#	Section	Preview
0	METHODS — GWAS meta-analysis	We performed an expanded GWAS meta-analysis for self-reported age at menarche in up to 182,416 women…
1	METHODS — GWAS meta-analysis	This array included up to ~25,000 SNPs, or their proxy markers, that showed sub-genome-wide…
2	METHODS — GWAS meta-analysis	On meta-analysis, 3,915 SNPs reached the genome-wide significance threshold (P<5×10−8) for…
3	METHODS — Selection of independent signals	Given the genome-wide results of the meta-analysis, SNPs showing evidence for association at…
4	METHODS — Selection of independent signals	To augment this list we performed approximate conditional analysis using GCTA software34, where the…
5	METHODS — Selection of independent signals	To summarize the information obtained from the single-SNP and GCTA analyses, the 105 SNPs selected…
6	METHODS — Selection of independent signals	To determine likely causal genes at each locus, we used a combination of criteria. The gene nearest…
7	METHODS — Follow up in the EPIC-InterAct study	We used an independent sample of 8689 women from the EPIC-InterAct study35 to follow-up our menarche…
8	METHODS — eQTL analyses	In order to estimate the potential downstream regulatory effects of age at menarche associated…
9	METHODS — eQTL analyses	Index SNPs (or highly correlated proxies) were also interrogated against a collected database of…
10	METHODS — eQTL analyses	prefrontal cortex, visual cortex and cerebellum, respectively66, liver58,67–70, osteoblasts71,…
11	METHODS — Parent-of-origin specific associations	Evidence for parent-of-origin specific allelic associations at imprinted loci was sought in the…
12	METHODS — Parent-of-origin specific associations	score reflecting the relative likelihood of the two possible parental origin assignments. Haplotypes…
13	METHODS — Pathway analyses	Meta-Analysis Gene-set Enrichment of variaNT Associations (MAGENTA) was used to explore…
14	METHODS — Pathway analyses	ranked score above the specified threshold percentile, is calculated. This observed statistic is…
15	METHODS — Relevance of menarche loci to other traits	We assessed the relevance of identified menarche loci to other traits by comparing SNPs…

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Adult height in girls with idiopathic central precocious puberty treated with triptorelin.	Corripio R et al.	—	2024	→
A Genetic Analysis of Current Medication Use in the UK Biobank.	Rohde PD	—	2024	→
Altered pubertal timing in 7q11.23 copy number variations and associated genetic mechanisms.	Wei SM et al.	—	2024	→
Association of Age at Menarche with General and Abdominal Obesity in Young Women.	Rakic R et al.	—	2024	→
Association of birth weight, childhood obesity, and age at menarche with the risk of ovarian dysfunction: A mendelian randomization study.	Dang C et al.	—	2024	→
Association of obesity and menarche SNPs and interaction with environmental factors on precocious puberty.	Xue P et al.	—	2024	→
Causal association of dietary factors with five common cancers: univariate and multivariate Mendelian randomization studies.	Yang L et al.	—	2024	→
Causal effects of female reproductive features on nonalcoholic fatty liver disease: A mendelian randomization study.	Fu H et al.	—	2024	→
Cloning, tissue expression and imprinting status analysis of the NDN gene in Dolang sheep.	Zhang Y et al.	—	2024	→
Creatine Acts as a Mediator of the Causal Effect of Obesity on Puberty Onset in Girls: Evidence from Mediation Mendelian Randomization Study.	Jin C et al.	—	2024	→
Development and application of a nomogram model for predicting the risk of central precocious puberty in obese girls.	Huang RH et al.	—	2024	→
Exploring the Genetic Risk of Childhood Daytime Urinary Incontinence: A Genome-Wide Association Study.	Breinbjerg A et al.	—	2024	→
Genetic Causality of Hypothyroidism and Adverse Pregnancy Outcomes: A Combined Mendelian Randomisation Study and Bioinformatics Analysis.	Feng Z et al.	—	2024	→
Genetic correlation and Mendelian randomization analyses support causal relationships between dietary habits and age at menarche.	Guo R et al.	—	2024	→
Genetic Prediction of Osteoporosis by Anti-Müllerian Hormone Levels and Reproductive Factors in Women: A Mendelian Randomization Study.	Li Y et al.	—	2024	→
Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring.	Benonisdottir S et al.	—	2024	→
Health condition and socioeconomic status mediate the causal effect of reproductive traits on nonalcoholic fatty liver disease: evidence from Mendelian randomization study.	Wang Q et al.	—	2024	→
Hormone and reproductive factors and risk of systemic lupus erythematosus: a Mendelian randomized study.	Chang R et al.	—	2024	→
Identifying causal associations between women's reproductive traits and risk of schizophrenia: a multivariate validated two-sample Mendelian randomization analysis.	Sun W et al.	—	2024	→
Impact of insomnia on ovarian cancer risk and survival: a Mendelian randomization study.	Wang H et al.	—	2024	→
Interaction between Vitamin D homeostasis, gut microbiota, and central precocious puberty.	Guo D et al.	—	2024	→
Maternal Age at Menarche Genes Determines Fetal Growth Restriction Risk.	Reshetnikov E et al.	—	2024	→
Mendelian randomization identifies circulating proteins as biomarkers for age at menarche and age at natural menopause.	Yazdanpanah N et al.	—	2024	→
Methylome analysis in girls with idiopathic central precocious puberty.	Palumbo S et al.	—	2024	→
Puberty classifications in beef heifers are moderately to highly heritable and associated with candidate genes related to cyclicity and timing of puberty.	Hess MK et al.	—	2024	→
Sex- and time-specific associations of obesity with glycaemic traits: A two-step multivariate Mendelian randomization study.	Tian Y et al.	—	2024	→
Study of <i>rs7759938</i>, <i>rs314280</i>, and <i>rs314276</i> Polymorphisms of <i>LIN28B</i> in Relation to Age at Menarche in Girls of Greek Descent.	Tsinopoulou VR et al.	—	2024	→
The causal effects of age at menarche and age at menopause on sepsis: A two-sample Mendelian randomization analysis.	Guo N et al.	—	2024	→
The genetic architecture of age at menarche and its causal effects on other traits.	Feng GJ et al.	—	2024	→
The impact of reproductive factors on the metabolic profile of females from menarche to menopause.	Clayton GL et al.	—	2024	→
Understanding the genetic complexity of puberty timing across the allele frequency spectrum.	Kentistou KA et al.	—	2024	→
Variable parallelism in the genomic basis of age at maturity across spatial scales in Atlantic Salmon.	Kess T et al.	—	2024	→
Age at Menarche Mediating Visceral Adipose Tissue's Influence on Pre-eclampsia: A Mendelian Randomization Study.	Deng P et al.	—	2023	→
Analysis of the Imprinting Status and Expression of the <i>MAGEL2</i> Gene During Initiation at Puberty in the Dolang Sheep.	Zhang Y et al.	—	2023	→
An atlas of genetic determinants of forearm fracture.	Nethander M et al.	—	2023	→
Association of the Estrogen Receptor 1 Polymorphisms rs2046210 and rs9383590 with the Risk, Age at Onset and Prognosis of Breast Cancer.	Miedl H et al.	—	2023	→
Bidirectional two-sample mendelian randomization analysis identifies causal associations between age at menarche and sarcopenia-related traits.	Fan W et al.	—	2023	→
Causal relationships between birth weight, childhood obesity and age at menarche: A two-sample Mendelian randomization analysis.	Wang L et al.	—	2023	→
Differential Expression of RNAseq Imprinted Genes from Bovine Females Before and After Puberty.	Karami K et al.	—	2023	→
DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study.	Sehovic E et al.	—	2023	→
Effect of women's fertility and sexual development on epigenetic clock: Mendelian randomization study.	Zhang B et al.	—	2023	→
Effects of half-dose spiomet treatment in girls with early puberty and accelerated bone maturation: a multicenter, randomized, placebo-controlled study protocol.	Bassols J et al.	—	2023	→
Endocrine Health and Health Care Disparities in the Pediatric and Sexual and Gender Minority Populations: An Endocrine Society Scientific Statement.	Diaz-Thomas AM et al.	—	2023	→
Establishing the relationships between adiposity and reproductive factors: a multivariable Mendelian randomization analysis.	Prince C et al.	—	2023	→
Genetic causal relationship between age at menarche and benign oesophageal neoplasia identified by a Mendelian randomization study.	Su Y et al.	—	2023	→
Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene.	Tsai MC et al.	—	2023	→
Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function.	Mortlock S et al.	—	2023	→
Gut microbiota and risk of five common cancers: A univariable and multivariable Mendelian randomization study.	Wei Z et al.	—	2023	→
Higher Prepubertal IGF-1 Concentrations Associate to Earlier Pubertal Tempo in Both Sexes.	Baier I et al.	—	2023	→
Identification and immune features of cuproptosis-related molecular clusters in polycystic ovary syndrome.	Su Z et al.	—	2023	→
Investigating the role of genetic variation in <i>vgll3</i> and <i>six6</i> in the domestication of gilthead seabream (<i>Sparus aurata</i> Linnaeus) and European seabass (<i>Dicentrarchus labrax</i> Linnaeus).	Moulistanos A et al.	—	2023	→
Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity.	Kaisinger LR et al.	—	2023	→
Long-term health consequences of central precocious/early puberty (CPP) and treatment with Gn-RH analogue: a short update.	Soliman AT et al.	—	2023	→
Major depression disorder may causally associate with the increased breast cancer risk: Evidence from two-sample mendelian randomization analyses.	Ren Q et al.	—	2023	→
Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight.	Reshetnikova Y et al.	—	2023	→
Mendelian randomization identifies age at menarche as an independent causal effect factor for gestational diabetes mellitus.	Lu L et al.	—	2023	→
MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity.	Naulé L et al.	—	2023	→
Novel MKRN3 Missense Mutations Associated With Central Precocious Puberty Reveal Distinct Effects on Ubiquitination.	Magnotto JC et al.	—	2023	→
Support Interval for Two-Sample Summary Data-Based Mendelian Randomization.	Wang K	—	2023	→
The Causal Effect of Reproductive Factors on Breast Cancer: A Two-Sample Mendelian Randomization Study.	Jia L et al.	—	2023	→
The Circadian Clock, Nutritional Signals and Reproduction: A Close Relationship.	Ono M et al.	—	2023	→
The Congenital and Acquired Mechanisms Implicated in the Etiology of Central Precocious Puberty.	Brito VN et al.	—	2023	→
The impact of age-specific childhood body-mass index on adult cardiometabolic traits: a Mendelian randomization study.	Yang J et al.	—	2023	→
Variations in gender identity and sexual orientation of university students.	Yoshida T et al.	—	2023	→
Age at menarche and ischemic heart disease: An update mendelian randomization study.	Chen J et al.	—	2022	→
Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study.	Nethander M et al.	—	2022	→
Association between Age at Menarche and Hyperhomocysteinemia among Women in Hunan, China: A Cross-Sectional Study.	Yang Y et al.	—	2022	→
Associations of Obesity with Linear Growth and Puberty.	Shalitin S et al.	—	2022	→
Childhood obesity and central precocious puberty.	Shi L et al.	—	2022	→
Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization.	Vabistsevits M et al.	—	2022	→
Different genes may be involved in distal and local sensitization: A genome-wide gene-based association study and meta-analysis.	Kouraki A et al.	—	2022	→
Dissecting the loci underlying maturation timing in Atlantic salmon using haplotype and multi-SNP based association methods.	Sinclair-Waters M et al.	—	2022	→
DNA methylation clocks for dogs and humans.	Horvath S et al.	—	2022	→
Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine.	Sánchez-Garrido MA et al.	—	2022	→
Estimation of Causal Effect of Age at Menarche on Pubertal Height Growth Using Mendelian Randomization.	Jo EJ et al.	—	2022	→
Genetically Determined Lifestyle and Cardiometabolic Risk Factors Mediate the Association of Genetically Predicted Age at Menarche With Genetic Predisposition to Myocardial Infarction: A Two-Step, Two-Sample Mendelian Randomization Study.	Zheng J et al.	—	2022	→
Genetic and Epigenetic Control of Puberty.	Manotas MC et al.	—	2022	→
Genetic, epigenetic and enviromental influencing factors on the regulation of precocious and delayed puberty.	Faienza MF et al.	—	2022	→
Genetic loci and metabolic states associated with murine epigenetic aging.	Mozhui K et al.	—	2022	→
Genetics of pubertal timing.	Mancini A et al.	—	2022	→
Hypothalamic Overexpression of Makorin Ring Finger Protein 3 Results in Delayed Puberty in Female Mice.	Roberts SA et al.	—	2022	→
Identifying Causes of Fracture Beyond Bone Mineral Density: Evidence From Human Genetics.	Lu T et al.	—	2022	→
Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis.	Lu M et al.	—	2022	→
Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation.	Mohamed AR et al.	—	2022	→
Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk.	D'Urso S et al.	—	2022	→
MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis.	LaPierre MP et al.	—	2022	→
NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes.	Østvold AC et al.	—	2022	→
Parent-of-Origin inference for biobanks.	Hofmeister RJ et al.	—	2022	→
PGS-server: accuracy, robustness and transferability of polygenic score methods for biobank scale studies.	Yang S et al.	—	2022	→
Predictive value of single-nucleotide polymorphisms in curve progression of adolescent idiopathic scoliosis.	Wang W et al.	—	2022	→
Refining the genomic location of single nucleotide polymorphism variation affecting Atlantic salmon maturation timing at a key large-effect locus.	Sinclair-Waters M et al.	—	2022	→
Review of human genetic and clinical studies directly relevant to GnRH signalling.	Seminara SB et al.	—	2022	→
Shared genetic basis between reproductive behaviors and anxiety-related disorders.	Ohi K et al.	—	2022	→
The contribution of imprinted genes to neurodevelopmental and neuropsychiatric disorders.	Isles AR	—	2022	→
The mechanism underlying the pubertal increase in pulsatile GnRH release in primates.	Terasawa E	—	2022	→
The relationships between women's reproductive factors: a Mendelian randomisation analysis.	Prince C et al.	—	2022	→
Using genetic instruments to estimate the causal effect of hormonal reproductive factors on osteoarthritis.	Wang B et al.	—	2022	→
Association of phthalates and early menarche in Korean adolescent girls from Korean National Environmental Health Survey (KoNEHS) 2015-2017.	Park O et al.	—	2021	→
BDNF Gene as a Precision Skill of Obesity Management.	Marcos-Pasero H et al.	—	2021	→
Central precocious puberty: Recent advances in understanding the aetiology and in the clinical approach.	Maione L et al.	—	2021	→
Coffee consumption and risk of breast cancer: A Mendelian randomization study.	Ellingjord-Dale M et al.	—	2021	→
Cohort profile: The COPENHAGEN Minipuberty Study-A longitudinal prospective cohort of healthy full-term infants and their parents.	Busch AS et al.	—	2021	→
Dynamic Expression of Imprinted Genes in the Developing and Postnatal Pituitary Gland.	Scagliotti V et al.	—	2021	→
Early menarche and its consequence in Korean female: reducing fructose intake could be one solution.	Kim JH et al.	—	2021	→
Effect of longevity genetic variants on the molecular aging rate.	Gurinovich A et al.	—	2021	→
Emerging Roles of Epigenetics in the Control of Reproductive Function: Focus on Central Neuroendocrine Mechanisms.	Vazquez MJ et al.	—	2021	→
Endocrine-Disrupting Chemicals and Early Puberty in Girls.	Papadimitriou A et al.	—	2021	→
Epigenetics of the developing and aging brain: Mechanisms that regulate onset and outcomes of brain reorganization.	Bacon ER et al.	—	2021	→
Genetic Regulation of Physiological Reproductive Lifespan and Female Fertility.	McGrath IM et al.	—	2021	→
Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium.	Marla S et al.	—	2021	→
Genome-wide survey of parent-of-origin-specific associations across clinical traits derived from electronic health records.	Kim HI et al.	—	2021	→
Heritability and association with distinct genetic loci of erythropoietin levels in the general population.	Corre T et al.	—	2021	→
Heterogeneous genetic basis of age at maturity in salmonid fishes.	Waters CD et al.	—	2021	→
Hypothalamic Ceramides and the Ovarian Sympathetic System: At the Crossroads of Obesity and Puberty.	Stamou MI et al.	—	2021	→
Identification of methylation changes associated with positive and negative growth deviance in Gambian infants using a targeted methyl sequencing approach of genomic DNA.	Quilter CR et al.	—	2021	→
Identifying causality, genetic correlation, priority and pathways of large-scale complex exposures of breast and ovarian cancers.	Si S et al.	—	2021	→
Insights from the genetic characterization of central precocious puberty associated with multiple anomalies.	Canton APM et al.	—	2021	→
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.	Võsa U et al.	—	2021	→
Lipid-Associated Variants near ANGPTL3 and LPL Show Parent-of-Origin Specific Effects on Blood Lipid Levels and Obesity.	Lessmark A et al.	—	2021	→
Neurobiology of puberty and its disorders.	Witchel SF et al.	—	2021	→
Pathogenic and Low-Frequency Variants in Children With Central Precocious Puberty.	Neocleous V et al.	—	2021	→
Reflection on modern methods: causal inference considerations for heterogeneous disease etiology.	Nevo D et al.	—	2021	→
Resource profile and user guide of the Polygenic Index Repository.	Becker J et al.	—	2021	→
Roles of HIF and 2-Oxoglutarate-Dependent Dioxygenases in Controlling Gene Expression in Hypoxia.	Frost J et al.	—	2021	→
Sex-specific genetic effects across biomarkers.	Flynn E et al.	—	2021	→
Shared Genetics Between Age at Menopause, Early Menopause, POI and Other Traits.	Louwers YV et al.	—	2021	→
The role of age at menarche and age at menopause in Alzheimer's disease: evidence from a bidirectional mendelian randomization study.	Li M et al.	—	2021	→
Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays.	Mulvey B et al.	—	2021	→
Age at onset of different pubertal signs in boys and girls and differential DNA methylation at age 10 and 18 years: an epigenome-wide follow-up study.	Chen S et al.	—	2020	→
Aging mechanisms-A perspective mostly from <i>Drosophila</i>.	Tsurumi A et al.	—	2020	→
An Appraisal of the Role of Previously Reported Risk Factors in the Age at Menopause Using Mendelian Randomization.	Ding X et al.	—	2020	→
Association Between Genetically Proxied Inhibition of HMG-CoA Reductase and Epithelial Ovarian Cancer.	Yarmolinsky J et al.	—	2020	→
Autozygosity influences cardiometabolic disease-associated traits in the AWI-Gen sub-Saharan African study.	Ceballos FC et al.	—	2020	→
Beyond large-effect loci: large-scale GWAS reveals a mixed large-effect and polygenic architecture for age at maturity of Atlantic salmon.	Sinclair-Waters M et al.	—	2020	→
Brain Development in School-Age and Adolescent Girls: Effects of Turner Syndrome, Estrogen Therapy, and Genomic Imprinting.	O'Donoghue S et al.	—	2020	→
Breast cancer risk factors and their effects on survival: a Mendelian randomisation study.	Escala-Garcia M et al.	—	2020	→
Candidate genes for age at menarche are associated with endometrial hyperplasia.	Ponomarenko I et al.	—	2020	→
Candidate Genes for Age at Menarche Are Associated With Uterine Leiomyoma.	Ponomarenko I et al.	—	2020	→
Cis-regulatory differences in isoform expression associate with life history strategy variation in Atlantic salmon.	Verta JP et al.	—	2020	→
Delayed and Precocious Puberty: Genetic Underpinnings and Treatments.	Gohil A et al.	—	2020	→
Developmental expression patterns of six6: A gene linked with spawning ecotypes in Atlantic salmon.	Moustakas-Verho JE et al.	—	2020	→
Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility.	Sciarra F et al.	—	2020	→
Early pubertal maturation and risk of childhood asthma: A Mendelian randomization and longitudinal study.	Chen YC et al.	—	2020	→
Endocrine-Disrupting Chemicals and Their Effects during Female Puberty: A Review of Current Evidence.	Lucaccioni L et al.	—	2020	→
Epigenome-wide association study of DNA methylation and microRNA expression highlights novel pathways for human complex traits.	Huan T et al.	—	2020	→
Evaluating and improving heritability models using summary statistics.	Speed D et al.	—	2020	→
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.	Quach BC et al.	—	2020	→
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.	Bryois J et al.	—	2020	→
GENETICS IN ENDOCRINOLOGY: Genetic etiologies of central precocious puberty and the role of imprinted genes.	Roberts SA et al.	—	2020	→
Levels of endocrine-disrupting chemicals are associated with changes in the peri-pubertal epigenome.	Almstrup K et al.	—	2020	→
Life History Transitions at the Origins of Agriculture: A Model for Understanding How Niche Construction Impacts Human Growth, Demography and Health.	Wells JCK et al.	—	2020	→
Lin28 gene and mammalian puberty.	Cao G et al.	—	2020	→
Makorin RING finger protein 3 and central precocious puberty.	Maione L et al.	—	2020	→
Makorin rings the kisspeptin bell to signal pubertal initiation.	Abbara A et al.	—	2020	→
Negative Effects of Age at Menarche on Risk of Cardiometabolic Diseases in Adulthood: A Mendelian Randomization Study.	Cao M et al.	—	2020	→
Onset and tempo of sexual maturation is differentially associated with gestational phthalate exposure between boys and girls in a Mexico City birth cohort.	Cathey A et al.	—	2020	→
RANKL is a new Epigenetic Biomarker for the Vasomotor Symptom During Menopause.	Kalkan R et al.	—	2020	→
Recent pubertal timing trends in Northern Taiwanese children: Comparison with skeletal maturity.	Chow JC et al.	—	2020	→
Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS.	Wu X et al.	—	2020	→
Searching for parent-of-origin effects on cardiometabolic traits in imprinted genomic regions.	Granot-Hershkovitz E et al.	—	2020	→
Steelhead (<i>Oncorhynchus mykiss</i>) lineages and sexes show variable patterns of association of adult migration timing and age-at-maturity traits with two genomic regions.	Willis SC et al.	—	2020	→
The effects of age at menarche and first sexual intercourse on reproductive and behavioural outcomes: A Mendelian randomization study.	Lawn RB et al.	—	2020	→
Transcription Profiles of Age-at-Maturity-Associated Genes Suggest Cell Fate Commitment Regulation as a Key Factor in the Atlantic Salmon Maturation Process.	Kurko J et al.	—	2020	→
Unravelling the role of epigenetics in reproductive adaptations to early-life environment.	Bar-Sadeh B et al.	—	2020	→
Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study.	Richardson TG et al.	—	2020	→
Age at Menarche and Blood Pressure in Pregnancy.	Petry CJ et al.	—	2019	→
Age at menarche and epithelial ovarian cancer risk: A meta-analysis and Mendelian randomization study.	Yang H et al.	—	2019	→
Central Precocious Puberty Caused by Novel Mutations in the Promoter and 5'-UTR Region of the Imprinted <i>MKRN3</i> Gene.	Fanis P et al.	—	2019	→
Dataset of allele, genotype and haplotype frequencies of four <i>LIN28B</i> gene polymorphisms analyzed for association with age at menarche in Russian women.	Ponomarenko I et al.	—	2019	→
Defining the genetic control of human blood plasma N-glycome using genome-wide association study.	Sharapov SZ et al.	—	2019	→
Delayed Puberty-Phenotypic Diversity, Molecular Genetic Mechanisms, and Recent Discoveries.	Howard SR et al.	—	2019	→
DLK1 Is a Novel Link Between Reproduction and Metabolism.	Gomes LG et al.	—	2019	→
DLK1, Notch Signaling and the Timing of Puberty.	Macedo DB et al.	—	2019	→
Dynamic Changes of DNA Methylation and Transcriptome Expression in Porcine Ovaries during Aging.	Xi X et al.	—	2019	→
Early-life exposure to endocrine-disrupting chemicals and pubertal development in girls.	Lee JE et al.	—	2019	→
Evolutionary Conservation of MKRN3 and Other Makorins and Their Roles in Puberty Initiation and Endocrine Functions.	Naulé L et al.	—	2019	→
Exome sequencing of Finnish isolates enhances rare-variant association power.	Locke AE et al.	—	2019	→
Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto's thyroiditis.	Brčić L et al.	—	2019	→
Genome-wide association study reveals sex-specific genetic architecture of facial attractiveness.	Hu B et al.	—	2019	→
Heritability of Age at Menarche in South Korean Female Twins.	Hur YM et al.	—	2019	→
HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases.	Jordan DM et al.	—	2019	→
<i>MKRN3</i> Mutations in Central Precocious Puberty: A Systematic Review and Meta-Analysis.	Valadares LP et al.	—	2019	→
Interdisciplinary Work Is Essential for Research on Puberty: Complexity and Dynamism in Action.	Susman EJ et al.	—	2019	→
Links between age at menarche, antral follicle count, and body mass index in African American and European American women.	Schuh SM et al.	—	2019	→
Low Frequency of MKRN3 and DLK1 Variants in Chinese Children with Central Precocious Puberty.	Chen T et al.	—	2019	→
MKRN3 Interacts With Several Proteins Implicated in Puberty Timing but Does Not Influence <i>GNRH1</i> Expression.	Yellapragada V et al.	—	2019	→
Molecular and Environmental Mechanisms Regulating Puberty Initiation: An Integrated Approach.	Livadas S et al.	—	2019	→
Paediatric and adult-onset male hypogonadism.	Salonia A et al.	—	2019	→
Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree.	Mozaffari SV et al.	—	2019	→
Parents of early-maturing girls die younger.	Hõrak P et al.	—	2019	→
Puberty and the Evolution of Developmental Science.	Worthman CM et al.	—	2019	→
Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility.	Lee AS et al.	—	2019	→
Review of the Literature on Current Changes in the Timing of Pubertal Development and the Incomplete Forms of Early Puberty.	Farello G et al.	—	2019	→
Signatures of replication timing, recombination, and sex in the spectrum of rare variants on the human X chromosome and autosomes.	Agarwal I et al.	—	2019	→
SumHer better estimates the SNP heritability of complex traits from summary statistics.	Speed D et al.	—	2019	→
The association between weight at birth and breast cancer risk revisited using Mendelian randomisation.	Kar SP et al.	—	2019	→
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects.	Middeldorp CM et al.	—	2019	→
The Genetic Basis of Delayed Puberty.	Howard SR	—	2019	→
The genetic relationship between female reproductive traits and six psychiatric disorders.	Ni G et al.	—	2019	→
The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis.	Devesa J et al.	—	2019	→
Thinking About the Evolution of Complex Traits in the Era of Genome-Wide Association Studies.	Sella G et al.	—	2019	→
Transient modification of lin28b expression - Permanent effects on zebrafish growth.	Leinonen JT et al.	—	2019	→
Age at menarche and adult body mass index: a Mendelian randomization study.	Gill D et al.	—	2018	→
Age at menarche and depressive symptoms in older Southern Chinese women: A Mendelian randomization study in the Guangzhou Biobank Cohort Study.	Au Yeung SL et al.	—	2018	→
Age at menarche and osteoporosis: A Mendelian randomization study.	Zhang Q et al.	—	2018	→
A genome scan for genes underlying adult body size differences between Central African hunter-gatherers and farmers.	Pemberton TJ et al.	—	2018	→
An Ancient Fecundability-Associated Polymorphism Creates a GATA2 Binding Site in a Distal Enhancer of HLA-F.	Mika KM et al.	—	2018	→
A population genetic interpretation of GWAS findings for human quantitative traits.	Simons YB et al.	—	2018	→
Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study.	Trajanoska K et al.	—	2018	→
Association between MKRN3 and LIN28B polymorphisms and precocious puberty.	Yi BR et al.	—	2018	→
Birth weight and the risk of histological subtypes of ovarian and endometrial cancers: Results from the Copenhagen School Health Records Register.	Trabert B et al.	—	2018	→
Central precocious puberty in Boston boys: A 10-year single center experience.	Topor LS et al.	—	2018	→
Characterizing the Relation Between Expression QTLs and Complex Traits: Exploring the Role of Tissue Specificity.	Ip HF et al.	—	2018	→
Complex genetics of female fertility.	Gajbhiye R et al.	—	2018	→
Congenital hypogonadotropic hypogonadism and constitutional delay of growth and puberty have distinct genetic architectures.	Cassatella D et al.	—	2018	→
Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty.	Howard SR et al.	—	2018	→
Differential Impact of Genetic Loci on Age at Thelarche and Menarche in Healthy Girls.	Busch AS et al.	—	2018	→
Dissection of genetic variation and evidence for pleiotropy in male pattern baldness.	Yap CX et al.	—	2018	→
Elucidating the genetic architecture of reproductive ageing in the Japanese population.	Horikoshi M et al.	—	2018	→
Exploring the association of genetic factors with participation in the Avon Longitudinal Study of Parents and Children.	Taylor AE et al.	—	2018	→
Father Absence and Accelerated Reproductive Development in Non-Hispanic White Women in the United States.	Gaydosh L et al.	—	2018	→
FineMAV: prioritizing candidate genetic variants driving local adaptations in human populations.	Szpak M et al.	—	2018	→
FUN-LDA: A Latent Dirichlet Allocation Model for Predicting Tissue-Specific Functional Effects of Noncoding Variation: Methods and Applications.	Backenroth D et al.	—	2018	→
Genes underlying delayed puberty.	Howard SR	—	2018	→
Genetically Determined Later Puberty Impacts Lowered Bone Mineral Density in Childhood and Adulthood.	Cousminer DL et al.	—	2018	→
GENETICS IN ENDOCRINOLOGY: Genetic diagnosis of endocrine diseases by NGS: novel scenarios and unpredictable results and risks.	Persani L et al.	—	2018	→
Genetics of pubertal timing.	Zhu J et al.	—	2018	→
Genome sequencing in the clinic: the past, present, and future of genomic medicine.	Prokop JW et al.	—	2018	→
Genome-wide analysis of nuclear magnetic resonance metabolites revealed parent-of-origin effect on triglycerides in medium very low-density lipoprotein in PTPRD gene.	Pervjakova N et al.	—	2018	→
Genome-wide survey of parent-of-origin effects on DNA methylation identifies candidate imprinted loci in humans.	Cuellar Partida G et al.	—	2018	→
Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes.	Thompson EE et al.	—	2018	→
HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases	Jordan DM et al.	—	2018	—
Hypothalamic epigenetics driving female puberty.	Toro CA et al.	—	2018	→
Identifying loci affecting trait variability and detecting interactions in genome-wide association studies.	Young AI et al.	—	2018	→
Impact of age at menarche on obesity and glycemic control in Japanese patients with type 2 diabetes: Fukuoka Diabetes Registry.	Sumi A et al.	—	2018	→
Insights into imprinting from parent-of-origin phased methylomes and transcriptomes.	Zink F et al.	—	2018	→
<i>STAT6</i>, <i>PBX2</i>, and <i>PBRM1</i> Emerge as Predicted Regulators of 452 Differentially Expressed Genes Associated With Puberty in Brahman Heifers.	Nguyen LT et al.	—	2018	→
Kallmann syndrome: phenotype and genotype of hypogonadotropic hypogonadism.	Stamou MI et al.	—	2018	→
Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.	Day F et al.	—	2018	→
Large-scale meta-analysis highlights the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length.	Laisk T et al.	—	2018	→
Methylome profiling of healthy and central precocious puberty girls.	Bessa DS et al.	—	2018	→
Partitioning Phenotypic Variance Due to Parent-of-Origin Effects Using Genomic Relatedness Matrices.	Laurin C et al.	—	2018	→
Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits.	Freund MK et al.	—	2018	→
Roles of NUCKS1 in Diseases: Susceptibility, Potential Biomarker, and Regulatory Mechanisms.	Huang P et al.	—	2018	→
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.	Ostrom QT et al.	—	2018	→
The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis.	Fernández-Rhodes L et al.	—	2018	→
The genomics of selenium: Its past, present and future.	Davy T et al.	—	2018	→
The tempo of human childhood: a maternal foot on the accelerator, a paternal foot on the brake.	Kotler J et al.	—	2018	→
Update Breast Cancer 2018 (Part 1) - Primary Breast Cancer and Biomarkers.	Taran FA et al.	—	2018	→
Whole-genome sequencing reveals new insights into age-related hearing loss: cumulative effects, pleiotropy and the role of selection.	Vuckovic D et al.	—	2018	→
Adult Consequences of Self-Limited Delayed Puberty.	Zhu J et al.	—	2017	→
Age at menarche and cardiovascular risk factors using Mendelian randomization in the Guangzhou Biobank Cohort Study.	Au Yeung SL et al.	—	2017	→
Age at menarche and lung function: a Mendelian randomization study.	Gill D et al.	—	2017	→
Age at Menarche and Risk of Multiple Sclerosis: A Prospective Cohort Study Based on the Danish National Birth Cohort.	Nielsen NM et al.	—	2017	→
Age at Menarche and Time Spent in Education: A Mendelian Randomization Study.	Gill D et al.	—	2017	→
A molecular census of arcuate hypothalamus and median eminence cell types.	Campbell JN et al.	—	2017	→
An ancient selective sweep linked to reproductive life history evolution in sockeye salmon.	Veale AJ et al.	—	2017	→
A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder.	Polimanti R et al.	—	2017	→
Association between age at menarche and cardiovascular disease: A systematic review on risk and potential mechanisms.	Luijken J et al.	—	2017	→
Association of genetic variation in the tachykinin receptor 3 locus with hot flashes and night sweats in the Women's Health Initiative Study.	Crandall CJ et al.	—	2017	→
Association of timing of menarche with depressive symptoms and depression in adolescence: Mendelian randomisation study.	Sequeira ME et al.	—	2017	→
[A survey of pubertal development in children born with assisted reproductive technology].	Liu ZY et al.	—	2017	→
Bioinformatic approaches to interrogating vitamin D receptor signaling.	Campbell MJ	—	2017	→
Characterization of natural variation in North American Atlantic Salmon populations (Salmonidae: <i>Salmo salar</i>) at a locus with a major effect on sea age.	Kusche H et al.	—	2017	→
Common variants in ZMIZ1 and near NGF confer risk for primary dysmenorrhoea.	Li Z et al.	—	2017	→
Disentangling puberty: novel neuroendocrine pathways and mechanisms for the control of mammalian puberty.	Avendaño MS et al.	—	2017	→
Dissecting the genetics of complex traits using summary association statistics.	Pasaniuc B et al.	—	2017	→
Diversity in non-repetitive human sequences not found in the reference genome.	Kehr B et al.	—	2017	→
Evidence for Very Recent Positive Selection in Mongolians.	Nakayama K et al.	—	2017	→
Gene expression profiling of puberty-associated genes reveals abundant tissue and sex-specific changes across postnatal development.	Hou H et al.	—	2017	→
Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.	Zhang G et al.	—	2017	→
Genetic determinants of adiponectin regulation revealed by pregnancy.	Hivert MF et al.	—	2017	→
Genetic Polymorphism of NUCKS1 Is Associated With the Susceptibility of Adolescent Idiopathic Scoliosis.	Xu L et al.	—	2017	→
Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations.	Kim-Hellmuth S et al.	—	2017	→
Genetic Variation of Follicle-Stimulating Hormone Action Is Associated With Age at Testicular Growth in Boys.	Busch AS et al.	—	2017	→
Genetic variations, reproductive aging, and breast cancer risk in African American and European American women: The Women's Circle of Health Study.	Coignet MV et al.	—	2017	→
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.	Day FR et al.	—	2017	→
Identification and evaluation of lncRNA and mRNA integrative modules in human peripheral blood mononuclear cells.	Mo XB et al.	—	2017	→
Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits.	Mancuso N et al.	—	2017	→
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis.	Zheng J et al.	—	2017	→
Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection.	Gazal S et al.	—	2017	→
Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex Traits.	Shi H et al.	—	2017	→
Mendelian randomization incorporating uncertainty about pleiotropy.	Thompson JR et al.	—	2017	→
Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness.	Heilmann-Heimbach S et al.	—	2017	→
Mining the topography and dynamics of the 4D Nucleome to identify novel CNS drug pathways.	Higgins GA et al.	—	2017	→
Nakalanga Syndrome: Clinical Characteristics, Potential Causes, and Its Relationship with Recently Described Nodding Syndrome.	Föger K et al.	—	2017	→
Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty.	Dauber A et al.	—	2017	→
Polymorphisms in JMJD1C are associated with pubertal onset in boys and reproductive function in men.	Mørup N et al.	—	2017	→
Predicting phenotypes from microarrays using amplified, initially marginal, eigenvector regression.	Ding L et al.	—	2017	→
Putative Effects of Obesity on Linear Growth and Puberty .	Shalitin S et al.	—	2017	→
Sequential recruitment of study participants may inflate genetic heritability estimates.	Noce D et al.	—	2017	→
Temple syndrome: comprehensive molecular and clinical findings in 32 Japanese patients.	Kagami M et al.	—	2017	→
Vitamin D Receptor Signaling and Cancer.	Campbell MJ et al.	—	2017	→
Advances in Dyslexia Genetics-New Insights Into the Role of Brain Asymmetries.	Paracchini S et al.	—	2016	→
Age at menarche and age at natural menopause in East Asian women: a genome-wide association study.	Shi J et al.	—	2016	→
Age at menarche and the risk of diabetic microvascular complications in patients with type 1 diabetes.	Harjutsalo V et al.	—	2016	→
Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants.	Hauberg ME et al.	—	2016	→
An Ancient Fecundability-Associated Polymorphism Switches a Repressor into an Enhancer of Endometrial TAP2 Expression.	Mika KM et al.	—	2016	→
Assessing the genetic architecture of epithelial ovarian cancer histological subtypes.	Cuellar-Partida G et al.	—	2016	→
A two-phase procedure for non-normal quantitative trait genetic association study.	Zhang W et al.	—	2016	→
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.	Dunning AM et al.	—	2016	→
Constitutional delay of puberty: presentation and inheritance pattern in 48 familial cases.	Winter S et al.	—	2016	→
Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data.	Shi H et al.	—	2016	→
Control of the onset of puberty.	Livadas S et al.	—	2016	→
Detection and interpretation of shared genetic influences on 42 human traits.	Pickrell JK et al.	—	2016	→
Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus.	Camp NJ et al.	—	2016	→
DNA methylation of LINE-1 and Alu repetitive elements in relation to sex hormones and pubertal timing in Mexican-American children.	Huen K et al.	—	2016	→
Dramatic acceleration of reproductive aging, contraction of biochemical fecundity and healthspan-lifespan implications of opioid-induced endocrinopathy-FSH/LH ratio and other interrelationships.	Reece AS et al.	—	2016	→
Epigenetic and genetic components of height regulation.	Benonisdottir S et al.	—	2016	→
Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes.	Pettigrew KA et al.	—	2016	→
Gene set analysis for interpreting genetic studies.	Pers TH	—	2016	→
Genetic evidence for natural selection in humans in the contemporary United States.	Beauchamp JP	—	2016	→
Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.	Ruth KS et al.	—	2016	→
Genome-wide analysis identifies 12 loci influencing human reproductive behavior.	Barban N et al.	—	2016	→
Genome-wide association study identifies common and low-frequency variants at the AMH gene locus that strongly predict serum AMH levels in males.	Perry JR et al.	—	2016	→
GWIS: Genome-Wide Inferred Statistics for Functions of Multiple Phenotypes.	Nieuwboer HA et al.	—	2016	→
Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.	Mbarek H et al.	—	2016	→
MANAGEMENT OF ENDOCRINE DISEASE: Reversible hypogonadotropic hypogonadism.	Dwyer AA et al.	—	2016	→
microRNAs and the adolescent brain: Filling the knowledge gap.	Rao YS et al.	—	2016	→
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.	Lu Y et al.	—	2016	→
New Perspectives on Genomic Imprinting, an Essential and Multifaceted Mode of Epigenetic Control in the Developing and Adult Brain.	Perez JD et al.	—	2016	→
Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond.	Laisk-Podar T et al.	—	2016	→
Physical and neurobehavioral determinants of reproductive onset and success.	Day FR et al.	—	2016	→
PLAG1 and NCAPG-LCORL in livestock.	Takasuga A	—	2016	→
Plasma levels of vitamin K and the risk of ischemic heart disease: a Mendelian randomization study.	Schooling CM	—	2016	→
Polymorphisms and genes associated with puberty in heifers.	Fortes MR et al.	—	2016	→
Population variation of LIN28B in the Mediterranean: Novel markers for microgeographic discrimination.	Álvarez-Álvarez MM et al.	—	2016	→
Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.	Bonilla C et al.	—	2016	→
Pubertal development and regulation.	Abreu AP et al.	—	2016	→
Pubertal development in healthy children is mirrored by DNA methylation patterns in peripheral blood.	Almstrup K et al.	—	2016	→
Puberty - genes, environment and clinical issues.	Kiess W et al.	—	2016	→
Puberty, Socioeconomic Status, and Depression in Girls: Evidence for Gene × Environment Interactions.	Mendle J et al.	—	2016	→
RASopathies Are Associated With Delayed Puberty; Are They Associated With Precocious Puberty Too?	van der Kaay DC et al.	—	2016	→
Recent advances in the understanding and management of delayed puberty.	Wei C et al.	—	2016	→
Refining the Use of Linkage Disequilibrium as a Robust Signature of Selective Sweeps.	Jacobs GS et al.	—	2016	→
Saving the spandrels? Adaptive genomic variation in conservation and fisheries management.	Pearse DE	—	2016	→
Sex-specific regulation of weight and puberty by the Lin28/let-7 axis.	Corre C et al.	—	2016	→
Significant impact of miRNA-target gene networks on genetics of human complex traits.	Okada Y et al.	—	2016	→
SLCO1B1*5 polymorphism (rs4149056) is associated with chemotherapy-induced amenorrhea in premenopausal women with breast cancer: a prospective cohort study.	Reimer T et al.	—	2016	→
The genetics of pubertal timing in the general population: recent advances and evidence for sex-specificity.	Cousminer DL et al.	—	2016	→
Transcriptome analyses identify five transcription factors differentially expressed in the hypothalamus of post- versus prepubertal Brahman heifers.	Fortes MR et al.	—	2016	→
UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females.	Yermachenko A et al.	—	2016	→
Uncovering the Genetic Architectures of Quantitative Traits.	Lee JJ et al.	—	2016	→
Withdrawn: Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era.	Stamou MI et al.	—	2016	→
An atlas of genetic correlations across human diseases and traits.	Bulik-Sullivan B et al.	—	2015	→
A new pathway in the control of the initiation of puberty: the MKRN3 gene.	Abreu AP et al.	—	2015	→
A shared genetic basis for self-limited delayed puberty and idiopathic hypogonadotropic hypogonadism.	Zhu J et al.	—	2015	→
Bivariate Genome-Wide Association Study Implicates ATP6V1G1 as a Novel Pleiotropic Locus Underlying Osteoporosis and Age at Menarche.	Tan LJ et al.	—	2015	→
Cohort Profile Update: the TRacking Adolescents' Individual Lives Survey (TRAILS).	Oldehinkel AJ et al.	—	2015	→
Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer.	O'Mara TA et al.	—	2015	→
Copy number variations and cognitive phenotypes in unselected populations.	Männik K et al.	—	2015	→
Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era.	Stamou MI et al.	—	2015	→
Does salt have a permissive role in the induction of puberty?	Pitynski D et al.	—	2015	→
Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression.	Lomniczi A et al.	—	2015	→
Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis.	Nead KT et al.	—	2015	→
Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism--pathogenesis, diagnosis and treatment.	Boehm U et al.	—	2015	→
Genetic Regulation of Puberty Timing in Humans.	Day FR et al.	—	2015	→
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index.	Yang J et al.	—	2015	→
Genomic imprinting: A missing piece of the Multiple Sclerosis puzzle?	Ruhrmann S et al.	—	2015	→
Identifying the biological basis of GWAS hits for endometriosis.	Fung JN et al.	—	2015	→
Impact of gene polymorphisms of gonadotropins and their receptors on human reproductive success.	Casarini L et al.	—	2015	→
Is it all determined at menarche?	Schnabel RB	—	2015	→
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.	Day FR et al.	—	2015	→
Molecular basis of imprinting disorders affecting chromosome 14: lessons from murine models.	Howard M et al.	—	2015	→
Molecular insights into the aetiology of female reproductive ageing.	Perry JR et al.	—	2015	→
Neuroendocrine control of the onset of puberty.	Plant TM	—	2015	→
Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults.	Hochner H et al.	—	2015	→
Partitioning heritability by functional annotation using genome-wide association summary statistics.	Finucane HK et al.	—	2015	→
Rare coding variants and X-linked loci associated with age at menarche.	Lunetta KL et al.	—	2015	→
Season of birth is associated with birth weight, pubertal timing, adult body size and educational attainment: a UK Biobank study.	Day FR et al.	—	2015	→
Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon.	Barson NJ et al.	—	2015	→
Shared genetic aetiology of puberty timing between sexes and with health-related outcomes.	Day FR et al.	—	2015	→
Study of Five Pubertal Transition-Related Gene Polymorphisms as Risk Factors for Premature Coronary Artery Disease in a Chinese Han Population.	Chen B et al.	—	2015	→
Targeted resequencing of the pericentromere of chromosome 2 linked to constitutional delay of growth and puberty.	Cousminer DL et al.	—	2015	→
The Cannabinoid Receptor 2 Q63R Variant Modulates the Relationship between Childhood Obesity and Age at Menarche.	Bellini G et al.	—	2015	→
The epigenomic landscape of African rainforest hunter-gatherers and farmers.	Fagny M et al.	—	2015	→
Widespread seasonal gene expression reveals annual differences in human immunity and physiology.	Dopico XC et al.	—	2015	→
Pubertal onset in girls is strongly influenced by genetic variation affecting FSH action.	Hagen CP et al.	—	2014	→