Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes.
paper
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- Authors
- GΓΆring, Harald H H; Curran, Joanne E; Johnson, Matthew P; Dyer, Thomas D; Charlesworth, Jac; Cole, Shelley A; Jowett, Jeremy B M; Abraham, Lawrence J; Rainwater, David L; Comuzzie, Anthony G; Mahaney, Michael C; Almasy, Laura; MacCluer, Jean W; Kissebah, Ahmed H; Collier, Gregory R; Moses, Eric K; Blangero, John
- Year
- 2007
- Journal
- Nature genetics
- PMID
- 17873875
- DOI
- 10.1038/ng2119
Quantitative differences in gene expression are thought to contribute to phenotypic differences between individuals. We generated genome-wide transcriptional profiles of lymphocyte samples from 1,240 participants in the San Antonio Family Heart Study. The expression levels of 85% of the 19,648 detected autosomal transcripts were significantly heritable. Linkage analysis uncovered >1,000 cis-regulated transcripts at a false discovery rate of 5% and showed that the expression quantitative trait loci with the most significant linkage evidence are often located at the structural locus of a given transcript. To highlight the usefulness of this much-enlarged map of cis-regulated transcripts for the discovery of genes that influence complex traits in humans, as an example we selected high-density lipoprotein cholesterol concentration as a phenotype of clinical importance, and identified the cis-regulated vanin 1 (VNN1) gene as harboring sequence variants that influence high-density lipoprotein cholesterol concentrations.
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| VNN2 regulates hepatic steroid synthesis in response to dietary changes. | Zhang S et al. | β | 2025 | β |
| Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles. | Sakaue S et al. | β | 2024 | β |
| BnIR: A multi-omics database with various tools for Brassica napus research and breeding. | Yang Z et al. | β | 2023 | β |
| Genome-wide evaluation of the effect of short tandem repeat variation on local DNA methylation. | Martin-Trujillo A et al. | β | 2023 | β |
| Human-genome single nucleotide polymorphisms affecting transcription factor binding and their role in pathogenesis. | Antontseva EV et al. | β | 2023 | β |
| Robust identification of regulatory variants (eQTLs) using a differential expression framework developed for RNA-sequencing. | Marrella MA et al. | β | 2023 | β |
| Expression quantitative trait loci in sheep liver and muscle contribute to variations in meat traits. | Yuan Z et al. | β | 2021 | β |
| Regulatory SNPs: Altered Transcription Factor Binding Sites Implicated in Complex Traits and Diseases. | Degtyareva AO et al. | β | 2021 | β |
| A 16q22.1 variant confers susceptibility to colorectal cancer as a distal regulator of ZFP90. | Yu CY et al. | β | 2020 | β |
| Effects of aging on gene expression in blood of captive Tibetan macaques ( <i>Macaca thibetana</i>) and comparisons with expression in humans. | Yan CC et al. | β | 2020 | β |
| Regulation of coenzyme A levels by degradation: the 'Ins and Outs'. | Naquet P et al. | β | 2020 | β |
| A Combined Transcriptomic and Genomic Analysis Identifies a Gene Signature Associated With the Response to Anti-TNF Therapy in Rheumatoid Arthritis. | Aterido A et al. | β | 2019 | β |
| Development of a tissue augmented Bayesian model for expression quantitative trait loci analysis. | Zhuang YH et al. | β | 2019 | β |
| Familial Interstitial 6q23.2 Deletion Including Eya4 Associated With Otofaciocervical Syndrome. | Gana S et al. | β | 2019 | β |
| Functional SNPs in the Human Autoimmunity-Associated Locus 17q12-21. | Ustiugova AS et al. | β | 2019 | β |
| Genetic Variation in Long-Range Enhancers. | Fullard JF et al. | β | 2019 | β |
| Leveraging allelic imbalance to refine fine-mapping for eQTL studies. | Zou J et al. | β | 2019 | β |
| OSCA: a tool for omic-data-based complex trait analysis. | Zhang F et al. | β | 2019 | β |
| Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. | Jun G et al. | β | 2018 | β |
| Evaluation of PrediXcan for prioritizing GWAS associations and predicting gene expression. | Li B et al. | β | 2018 | β |
| Familial resemblances in human whole blood transcriptome. | Tremblay BL et al. | β | 2018 | β |
| Genetic association of molecular traits: A help to identify causative variants in complex diseases. | Vandiedonck C | β | 2018 | β |
| Genetic variants influencing phenotypic variance heterogeneity. | Ek WE et al. | β | 2018 | β |
| Genome-wide Analysis of Transcriptional Variability in a Large Maize-Teosinte Population. | Wang X et al. | β | 2018 | β |
| Identification of expression quantitative trait loci (eQTLs) in human peripheral blood mononuclear cells (PBMCs) and shared with liver and brain. | He P et al. | β | 2018 | β |
| Progranulin levels in blood in Alzheimer's disease and mild cognitive impairment. | Cooper YA et al. | β | 2018 | β |
| Quantitative Trait Transcripts Mapping Coupled with Expression Quantitative Trait Loci Mapping Reveal the Molecular Network Regulating the Apetalous Characteristic in <i>Brassica napus</i> L. | Yu K et al. | β | 2018 | β |
| ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice. | Weerasekera L et al. | β | 2017 | β |
| An independent component analysis confounding factor correction framework for identifying broad impact expression quantitative trait loci. | Ju JH et al. | β | 2017 | β |
| Assessment of imprinting- and genetic variation-dependent monoallelic expression using reciprocal allele descendants between human family trios. | Chuang TJ et al. | β | 2017 | β |
| High-level expression of a novel chromoplast phosphate transporter ClPHT4;2 is required for flesh color development in watermelon. | Zhang J et al. | β | 2017 | β |
| The effect of genetic variation on promoter usage and enhancer activity. | Garieri M et al. | β | 2017 | β |
| TRAK2, a novel regulator of ABCA1 expression, cholesterol efflux and HDL biogenesis. | Lake NJ et al. | β | 2017 | β |
| Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression. | Traurig M et al. | β | 2016 | β |
| A Pharmacogenetic Discovery: Cystamine Protects Against Haloperidol-Induced Toxicity and Ischemic Brain Injury. | Zhang H et al. | β | 2016 | β |
| Association of genetic variations and gene expression in a family-based study. | Pitsillides AN et al. | β | 2016 | β |
| A trans-acting Variant within the Transcription Factor RIM101 Interacts with Genetic Background to Determine its Regulatory Capacity. | Read T et al. | β | 2016 | β |
| A variance component method for integrated pathway analysis of gene expression data. | Quillen EE et al. | β | 2016 | β |
| Characterization of Expression Quantitative Trait Loci in Pedigrees from Colombia and Costa Rica Ascertained for Bipolar Disorder. | Peterson CB et al. | β | 2016 | β |
| Consensus Genome-Wide Expression Quantitative Trait Loci and Their Relationship with Human Complex Trait Disease. | Yu CH et al. | β | 2016 | β |
| eQTL analysis links inflammatory bowel disease associated 1q21 locus to ECM1 gene. | Repnik K et al. | β | 2016 | β |
| Factors associated with heterogeneity in microarray gene expression in peripheral blood mononuclear cells from large pedigrees. | Gallaugher M et al. | β | 2016 | β |
| Gene Expression Differences Between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene. | Yerges-Armstrong LM et al. | β | 2016 | β |
| Gene expression in large pedigrees: analytic approaches. | Cantor RM et al. | β | 2016 | β |
| Genetic complexity at expression quantitative trait loci. | Cantor RM et al. | β | 2016 | β |
| GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans. | Chittoor G et al. | β | 2016 | β |
| Methylation of SOCS3 is inversely associated with metabolic syndrome in an epigenome-wide association study of obesity. | Ali O et al. | β | 2016 | β |
| Omics-squared: human genomic, transcriptomic and phenotypic data for genetic analysis workshop 19. | Blangero J et al. | β | 2016 | β |
| Pervasive Effects of Aging on Gene Expression in Wild Wolves. | Charruau P et al. | β | 2016 | β |
| Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination. | Fourati S et al. | β | 2016 | β |
| The abundance of cis-acting loci leading to differential allele expression in F1 mice and their relationship to loci harboring genes affecting complex traits. | Yeo S et al. | β | 2016 | β |
| Trans-Omics: How To Reconstruct Biochemical Networks Across Multiple 'Omic' Layers. | Yugi K et al. | β | 2016 | β |
| TreeQTL: hierarchical error control for eQTL findings. | Peterson CB et al. | β | 2016 | β |
| Using gene expression data to identify causal pathways between genotype and phenotype in a complex disease: application to Genetic Analysis Workshop 19. | Ainsworth HF et al. | β | 2016 | β |
| A systematic heritability analysis of the human whole blood transcriptome. | Huan T et al. | β | 2015 | β |
| Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding lociβ . | Kirsten H et al. | β | 2015 | β |
| Effects of copy number variable regions on local gene expression in white blood cells of Mexican Americans. | Blackburn A et al. | β | 2015 | β |
| EGLN2 and RNF150 genetic variants are associated with chronic obstructive pulmonary disease risk in the Chinese population. | Ding Y et al. | β | 2015 | β |
| Exploiting genetic variation to discover genes involved in important disease phenotypes. | Capewell P et al. | β | 2015 | β |
| Genetic architecture of early pre-inflammatory stage transcription signatures of autoimmune diabetes in the pancreatic lymph nodes of the NOD mouse reveals significant gene enrichment on chromosomes 6 and 7. | Regnault B et al. | β | 2015 | β |
| Genome-wide epistatic expression quantitative trait loci discovery in four human tissues reveals the importance of local chromosomal interactions governing gene expression. | Fitzpatrick DJ et al. | β | 2015 | β |
| MiRNA Profiles in Lymphoblastoid Cell Lines of Finnish Prostate Cancer Families. | Fischer D et al. | β | 2015 | β |
| Seasonal effects on gene expression. | Goldinger A et al. | β | 2015 | β |
| The genetic and mechanistic basis for variation in gene regulation. | Pai AA et al. | β | 2015 | β |
| The role of regulatory variation in complex traits and disease. | Albert FW et al. | β | 2015 | β |
| Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection. | Hassan MA et al. | β | 2015 | β |
| Transcriptomic identification of ADH1B as a novel candidate gene for obesity and insulin resistance in human adipose tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES). | Winnier DA et al. | β | 2015 | β |
| Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. | Wood AR et al. | β | 2015 | β |
| An atlas of active enhancers across human cell types and tissues. | Andersson R et al. | β | 2014 | β |
| Arguments for the sake of endophenotypes: examining common misconceptions about the use of endophenotypes in psychiatric genetics. | Glahn DC et al. | β | 2014 | β |
| Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals. | Battle A et al. | β | 2014 | β |
| Common genetic variants and gene expression associated with white matter microstructure in the human brain. | Sprooten E et al. | β | 2014 | β |
| Comprehensive analysis of gene expression in human retina and supporting tissues. | Li M et al. | β | 2014 | β |
| Confounding by linkage disequilibrium. | Aissani B | β | 2014 | β |
| Data for Genetic Analysis Workshop 18: human whole genome sequence, blood pressure, and simulated phenotypes in extended pedigrees. | Almasy L et al. | β | 2014 | β |
| Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. | Ganesh SK et al. | β | 2014 | β |
| Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility. | Das SK et al. | β | 2014 | β |
| Expression quantitative trait loci infer the regulation of isoflavone accumulation in soybean (Glycine max L. Merr.) seed. | Wang Y et al. | β | 2014 | β |
| Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. | Tragante V et al. | β | 2014 | β |
| Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes. | Zhang X et al. | β | 2014 | β |
| Genetics of gene expression in immunity to infection. | Fairfax BP et al. | β | 2014 | β |
| Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens. | Rubicz R et al. | β | 2014 | β |
| High-Performance Mixed Models Based Genome-Wide Association Analysis with omicABEL software. | Fabregat-Traver D et al. | β | 2014 | β |
| Identification of gene signatures for prednisolone-induced metabolic dysfunction in collagen-induced arthritic mice. | Ellero-Simatos S et al. | β | 2014 | β |
| Large-scale East-Asian eQTL mapping reveals novel candidate genes for LD mapping and the genomic landscape of transcriptional effects of sequence variants. | Narahara M et al. | β | 2014 | β |
| Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging. | van den Akker EB et al. | β | 2014 | β |
| Molecular prioritization strategies to identify functional genetic variants in the cardiovascular disease-associated expression QTL Vanin-1. | Kaskow BJ et al. | β | 2014 | β |
| Network-based identification of biomarkers coexpressed with multiple pathways. | Guo NL et al. | β | 2014 | β |
| Novel distal eQTL analysis demonstrates effect of population genetic architecture on detecting and interpreting associations. | Weiser M et al. | β | 2014 | β |
| Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. | Perry JR et al. | β | 2014 | β |
| Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. | Postmus I et al. | β | 2014 | β |
| Plasma levels of soluble interleukin 1 receptor accessory protein are reduced in obesity. | Bozaoglu K et al. | β | 2014 | β |
| RTeQTL: Real-Time Online Engine for Expression Quantitative Trait Loci Analyses. | Ma B et al. | β | 2014 | β |
| Shared signatures of social stress and aging in peripheral blood mononuclear cell gene expression profiles. | Snyder-Mackler N et al. | β | 2014 | β |
| Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs. | Zhang X et al. | β | 2014 | β |
| Transcriptome sequencing of Chinese and Caucasian population identifies ethnic-associated differential transcript abundance of heterogeneous nuclear ribonucleoprotein K (hnRNPK). | Li JW et al. | β | 2014 | β |
| Trans-ethnic meta-analysis of white blood cell phenotypes. | Keller MF et al. | β | 2014 | β |
| Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms. | Bloom AJ et al. | β | 2014 | β |
| A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation. | Zhang Y et al. | β | 2013 | β |
| A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines. | Liang L et al. | β | 2013 | β |
| A genetical genomics approach reveals new candidates and confirms known candidate genes for drip loss in a porcine resource population. | Heidt H et al. | β | 2013 | β |
| A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). | Rubicz R et al. | β | 2013 | β |
| Analysis of the transcriptome in molecular epidemiology studies. | McHale CM et al. | β | 2013 | β |
| Analysis of time-resolved gene expression measurements across individuals. | Elo LL et al. | β | 2013 | β |
| A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology. | Bogdan R et al. | β | 2013 | β |
| An expression atlas of human primary cells: inference of gene function from coexpression networks. | Mabbott NA et al. | β | 2013 | β |
| Changes in splicing factor expression are associated with advancing age in man. | Holly AC et al. | β | 2013 | β |
| Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. | van Meurs JB et al. | β | 2013 | β |
| Detection and impact of rare regulatory variants in human disease. | Li X et al. | β | 2013 | β |
| Differential gene expression at the maternal-fetal interface in preeclampsia is influenced by gestational age. | Lian IA et al. | β | 2013 | β |
| Expression quantitative trait loci: present and future. | Nica AC et al. | β | 2013 | β |
| Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a Northern European family population. | Zhang Y et al. | β | 2013 | β |
| Functional polymorphisms in the regulatory regions of the VNN1 gene are associated with susceptibility to inflammatory bowel diseases. | Gensollen T et al. | β | 2013 | β |
| Genetic basis for the increased expression of vacuolar H+ translocating ATPase genes upon imatinib treatment in human lymphoblastoid cells. | Kulkarni H et al. | β | 2013 | β |
| Genome-Wide Detection of Gene Coexpression Domains Showing Linkage to Regions Enriched with Polymorphic Retrotransposons in Recombinant Inbred Mouse Strains. | Scott-Boyer MP et al. | β | 2013 | β |
| Genome-wide haplotype analysis of cis expression quantitative trait loci in monocytes. | Garnier S et al. | β | 2013 | β |
| Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. | Tanaka T et al. | β | 2013 | β |
| Genome-wide survey of interindividual differences of RNA stability in human lymphoblastoid cell lines. | Duan J et al. | β | 2013 | β |
| Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver. | SchrΓΆder A et al. | β | 2013 | β |
| Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype. | Gagneur J et al. | β | 2013 | β |
| Global properties and functional complexity of human gene regulatory variation. | Gaffney DJ | β | 2013 | β |
| Identification of genetic variants influencing the human plasma proteome. | Johansson Γ et al. | β | 2013 | β |
| Identification of single nucleotide polymorphisms regulating peripheral blood mRNA expression with genome-wide significance: an eQTL study in the Japanese population. | Sasayama D et al. | β | 2013 | β |
| Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood. | Mehta D et al. | β | 2013 | β |
| Insights from genome-wide association studies of drug response. | Zhou K et al. | β | 2013 | β |
| Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs. | Brown CD et al. | β | 2013 | β |
| Large-scale profiling and identification of potential regulatory mechanisms for allelic gene expression in colorectal cancer cells. | Lee RD et al. | β | 2013 | β |
| Loci influencing blood pressure identified using a cardiovascular gene-centric array. | Ganesh SK et al. | β | 2013 | β |
| Mapping eQTLs in the Norfolk Island genetic isolate identifies candidate genes for CVD risk traits. | Benton MC et al. | β | 2013 | β |
| New aQTL SNPs for the CYP2D6 identified by a novel mediation analysis of genome-wide SNP arrays, gene expression arrays, and CYP2D6 activity. | Jiang G et al. | β | 2013 | β |
| Post genome-wide association studies functional characterization of prostate cancer risk loci. | Jiang J et al. | β | 2013 | β |
| QTL-based association analyses reveal novel genes influencing pleiotropy of metabolic syndrome (MetS). | Zhang Y et al. | β | 2013 | β |
| Random generalized linear model: a highly accurate and interpretable ensemble predictor. | Song L et al. | β | 2013 | β |
| Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk. | McManus DD et al. | β | 2013 | β |
| RNA-Seq and human complex diseases: recent accomplishments and future perspectives. | Costa V et al. | β | 2013 | β |
| Systems genetics in "-omics" era: current and future development. | Li H | β | 2013 | β |
| Towards a gene expression biomarker set for human biological age. | Holly AC et al. | β | 2013 | β |
| Transcriptome study of differential expression in schizophrenia. | Sanders AR et al. | β | 2013 | β |
| Transcriptomics of cortical gray matter thickness decline during normal aging. | Kochunov P et al. | β | 2013 | β |
| ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-Ξ±. | Jowett JB et al. | β | 2012 | β |
| A description of large-scale metabolomics studies: increasing value by combining metabolomics with genome-wide SNP genotyping and transcriptional profiling. | Homuth G et al. | β | 2012 | β |
| Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. | Harries LW et al. | β | 2012 | β |
| An integrated hierarchical Bayesian model for multivariate eQTL mapping. | Scott-Boyer MP et al. | β | 2012 | β |
| A non-human primate system for large-scale genetic studies of complex traits. | Jasinska AJ et al. | β | 2012 | β |
| A review of genetics, arterial stiffness, and blood pressure in African Americans. | Hall JL et al. | β | 2012 | β |
| Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines. | Kulkarni H et al. | β | 2012 | β |
| A systematic eQTL study of cis-trans epistasis in 210 HapMap individuals. | Becker J et al. | β | 2012 | β |
| Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. | Zou F et al. | β | 2012 | β |
| Clinical and genetic correlates of growth differentiation factor 15 in the community. | Ho JE et al. | β | 2012 | β |
| Comparison of co-expression measures: mutual information, correlation, and model based indices. | Song L et al. | β | 2012 | β |
| Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression. | Greliche N et al. | β | 2012 | β |
| Diverse biological activities of the vascular non-inflammatory molecules - the Vanin pantetheinases. | Kaskow BJ et al. | β | 2012 | β |
| Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer. | Shen J et al. | β | 2012 | β |
| Exploiting gene expression variation to capture gene-environment interactions for disease. | Idaghdour Y et al. | β | 2012 | β |
| Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes. | de Jong S et al. | β | 2012 | β |
| From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era. | Baxter AG et al. | β | 2012 | β |
| Gene expression of peripheral blood mononuclear cells as a tool in dietary intervention studies: What do we know so far? | de Mello VD et al. | β | 2012 | β |
| Gene expression variations: potentialities of master regulator polymorphisms in colorectal cancer risk. | Pardini B et al. | β | 2012 | β |
| Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent. | Powell JE et al. | β | 2012 | β |
| Genome-wide association and functional follow-up reveals new loci for kidney function. | Pattaro C et al. | β | 2012 | β |
| Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. | Fox CS et al. | β | 2012 | β |
| Genome-wide association of pericardial fat identifies a unique locus for ectopic fat. | Fox CS et al. | β | 2012 | β |
| Genomewide association studies in cardiovascular disease--an update 2011. | Zeller T et al. | β | 2012 | β |
| GenotypeΓage interaction in human transcriptional ageing. | Kent JW et al. | β | 2012 | β |
| Heritable polymorphism predisposes to high BAALC expression in acute myeloid leukemia. | Eisfeld AK et al. | β | 2012 | β |
| High dimensional endophenotype ranking in the search for major depression risk genes. | Glahn DC et al. | β | 2012 | β |
| Identification of cis-regulatory variation influencing protein abundance levels in human plasma. | Lourdusamy A et al. | β | 2012 | β |
| Identifying the genetic variation of gene expression using gene sets: application of novel gene Set eQTL approach to PharmGKB and KEGG. | Abo R et al. | β | 2012 | β |
| Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project. | Auer PL et al. | β | 2012 | β |
| Integrating genomic analysis with the genetic basis of gene expression: preliminary evidence of the identification of causal genes for cardiovascular and metabolic traits related to nutrition in Mexicans. | Bastarrachea RA et al. | β | 2012 | β |
| Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. | Chasman DI et al. | β | 2012 | β |
| Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines. | Berlivet S et al. | β | 2012 | β |
| Mapping cis- and trans-regulatory effects across multiple tissues in twins. | Grundberg E et al. | β | 2012 | β |
| Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS. | Diekstra FP et al. | β | 2012 | β |
| Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. | Stolk L et al. | β | 2012 | β |
| Next steps in cardiovascular disease genomic research--sequencing, epigenetics, and transcriptomics. | Schnabel RB et al. | β | 2012 | β |
| Novel associations of nonstructural Loci with paraoxonase activity. | Quillen EE et al. | β | 2012 | β |
| Novel late-onset Alzheimer disease loci variants associate with brain gene expression. | Allen M et al. | β | 2012 | β |
| P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans. | Kochunov P et al. | β | 2012 | β |
| Resolving the variable genome and epigenome in human disease. | Knight JC | β | 2012 | β |
| RNA-Seq identifies SNP markers for growth traits in rainbow trout. | Salem M et al. | β | 2012 | β |
| Segregation of regulatory polymorphisms with effects on the gluteus medius transcriptome in a purebred pig population. | CΓ‘novas A et al. | β | 2012 | β |
| Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. | Perry JR et al. | β | 2012 | β |
| Systems genetics of the nuclear factor-ΞΊB signal transduction network. I. Detection of several quantitative trait loci potentially relevant to aging. | Diego VP et al. | β | 2012 | β |
| The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type. | Jendrzejewski J et al. | β | 2012 | β |
| The role of phenotype in gene discovery in the whole genome sequencing era. | Almasy L | β | 2012 | β |
| Tissue specificity of genetic regulation of gene expression. | GΓΆring HH | β | 2012 | β |
| Use of functional genomics to identify candidate genes underlying human genetic association studies of vascular diseases. | Yang X | β | 2012 | β |
| Validation study of existing gene expression signatures for anti-TNF treatment in patients with rheumatoid arthritis. | Toonen EJ et al. | β | 2012 | β |
| Variants in CPT1A, FADS1, and FADS2 are Associated with Higher Levels of Estimated Plasma and Erythrocyte Delta-5 Desaturases in Alaskan Eskimos. | Voruganti VS et al. | β | 2012 | β |
| VNN1 gene expression levels and the G-137T polymorphism are associated with HDL-C levels in Mexican prepubertal children. | Jacobo-Albavera L et al. | β | 2012 | β |
| A gene expression signature for insulin resistance. | Konstantopoulos N et al. | β | 2011 | β |
| Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). | Wassel CL et al. | β | 2011 | β |
| A transcriptional profile of the decidua in preeclampsia. | LΓΈset M et al. | β | 2011 | β |
| Blood pressure and cerebral white matter share common genetic factors in Mexican Americans. | Kochunov P et al. | β | 2011 | β |
| CUBN is a gene locus for albuminuria. | BΓΆger CA et al. | β | 2011 | β |
| Discretization provides a conceptually simple tool to build expression networks. | Vass JK et al. | β | 2011 | β |
| From expression QTLs to personalized transcriptomics. | Montgomery SB et al. | β | 2011 | β |
| Gene expression endophenotypes: a novel approach for gene discovery in Alzheimer's disease. | Ertekin-Taner N | β | 2011 | β |
| Genetical genomics of Th1 and Th2 immune response in a baboon model of atherosclerosis risk factors. | Vinson A et al. | β | 2011 | β |
| Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain. | Kochunov P et al. | β | 2011 | β |
| Genetics of schizophrenia: new findings and challenges. | Gejman PV et al. | β | 2011 | β |
| Genomics and genetics in the biology of adaptation to exercise. | Bouchard C et al. | β | 2011 | β |
| Global analysis of the impact of environmental perturbation on cis-regulation of gene expression. | Grundberg E et al. | β | 2011 | β |
| Identification of ACOX2 as a shared genetic risk factor for preeclampsia and cardiovascular disease. | Johansson A et al. | β | 2011 | β |
| Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes. | Carless MA et al. | β | 2011 | β |
| Increased endoplasmic reticulum stress in decidual tissue from pregnancies complicated by fetal growth restriction with and without pre-eclampsia. | Lian IA et al. | β | 2011 | β |
| Integrating expression profiling and whole-genome association for dissection of fat traits in a porcine model. | Ponsuksili S et al. | β | 2011 | β |
| Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans. | Rotival M et al. | β | 2011 | β |
| Integrative genomics strategies to elucidate the complexity of drug response. | Kasarskis A et al. | β | 2011 | β |
| Linkage analysis without defined pedigrees. | Day-Williams AG et al. | β | 2011 | β |
| Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver disease. | Sookoian S et al. | β | 2011 | β |
| Macrophages.com: an on-line community resource for innate immunity research. | Robert C et al. | β | 2011 | β |
| Network Medicine: New Paradigm in the -Omics Era. | Guo NL | β | 2011 | β |
| Partial correlation network analyses to detect altered gene interactions in human disease: using preeclampsia as a model. | Johansson A et al. | β | 2011 | β |
| Prednisolone-induced changes in gene-expression profiles in healthy volunteers. | Toonen EJ et al. | β | 2011 | β |
| Progress and promise of genome-wide association studies for human complex trait genetics. | Stranger BE et al. | β | 2011 | β |
| Regulatory variation within and between species. | Zheng W et al. | β | 2011 | β |
| RNA sequencing reveals the role of splicing polymorphisms in regulating human gene expression. | Lalonde E et al. | β | 2011 | β |
| Strategies for aggregating gene expression data: the collapseRows R function. | Miller JA et al. | β | 2011 | β |
| Survey of the effect of genetic variations on gene expression in human prefrontal cortex and its application to genetics of psychiatric disorders. | Iwamoto K et al. | β | 2011 | β |
| The architecture of gene regulatory variation across multiple human tissues: the MuTHER study. | Nica AC et al. | β | 2011 | β |
| The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol. | Leduc MS et al. | β | 2011 | β |
| The study of eQTL variations by RNA-seq: from SNPs to phenotypes. | Majewski J et al. | β | 2011 | β |
| The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits. | Min JL et al. | β | 2011 | β |
| Unifying ideas for non-parametric linkage analysis. | Day-Williams AG et al. | β | 2011 | β |
| A global analysis of QTLs for expression variations in rice shoots at the early seedling stage. | Wang J et al. | β | 2010 | β |
| Allele-specific DNA methylation: beyond imprinting. | Tycko B | β | 2010 | β |
| Allelic expression imbalance at high-density lipoprotein cholesterol locus MMAB-MVK. | Fogarty MP et al. | β | 2010 | β |
| Animal models of virus-induced neurobehavioral sequelae: recent advances, methodological issues, and future prospects. | Bortolato M et al. | β | 2010 | β |
| An immune response network associated with blood lipid levels. | Inouye M et al. | β | 2010 | β |
| An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6. | Fairfax BP et al. | β | 2010 | β |
| A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data. | Barbosa-Morais NL et al. | β | 2010 | β |
| Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study. | Melton PE et al. | β | 2010 | β |
| Blood mononuclear cell gene expression signature of postpartum depression. | Segman RH et al. | β | 2010 | β |
| Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations. | Nica AC et al. | β | 2010 | β |
| Chemerin, a novel adipokine in the regulation of angiogenesis. | Bozaoglu K et al. | β | 2010 | β |
| Coordinated expression domains in mammalian genomes. | Woo YH et al. | β | 2010 | β |
| Detection, validation, and downstream analysis of allelic variation in gene expression. | Ciobanu DC et al. | β | 2010 | β |
| Evolutionary history of regulatory variation in human populations. | Lappalainen T et al. | β | 2010 | β |
| Expression quantitative trait loci analysis of genes in porcine muscle by quantitative real-time RT-PCR compared to microarray data. | Ponsuksili S et al. | β | 2010 | β |
| Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells. | Dombroski BA et al. | β | 2010 | β |
| Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals. | Ding J et al. | β | 2010 | β |
| Gene expression profiling in C57BL/6J and A/J mouse inbred strains reveals gene networks specific for brain regions independent of genetic background. | de Jong S et al. | β | 2010 | β |
| Gene expression studies in major depression. | Mehta D et al. | β | 2010 | β |
| Genes and pathways contributing to obesity: a systems biology view. | Drake TA | β | 2010 | β |
| Genetic causes of high and low serum HDL-cholesterol. | Weissglas-Volkov D et al. | β | 2010 | β |
| Genetics and beyond--the transcriptome of human monocytes and disease susceptibility. | Zeller T et al. | β | 2010 | β |
| Genetics of microstructure of cerebral white matter using diffusion tensor imaging. | Kochunov P et al. | β | 2010 | β |
| Genetic variation at the FTO locus influences RBL2 gene expression. | Jowett JB et al. | β | 2010 | β |
| Genetic variation in PARL influences mitochondrial content. | Curran JE et al. | β | 2010 | β |
| Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing. | Heap GA et al. | β | 2010 | β |
| Geographical genomics of human leukocyte gene expression variation in southern Morocco. | Idaghdour Y et al. | β | 2010 | β |
| Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease. | Gawrieh S et al. | β | 2010 | β |
| Identification of expression QTL (eQTL) of genes expressed in porcine M. longissimus dorsi and associated with meat quality traits. | Ponsuksili S et al. | β | 2010 | β |
| Increasing alternative promoter repertories is positively associated with differential expression and disease susceptibility. | Liu S | β | 2010 | β |
| Inferred relatedness and heritability in malaria parasites. | Anderson TJ et al. | β | 2010 | β |
| INSIG1 influences obesity-related hypertriglyceridemia in humans. | Smith EM et al. | β | 2010 | β |
| Insights from GWAS into the quantitative genetics of transcription in humans. | Kim J et al. | β | 2010 | β |
| Integrative analysis of low- and high-resolution eQTL. | Loguercio S et al. | β | 2010 | β |
| Is human blood a good surrogate for brain tissue in transcriptional studies? | Cai C et al. | β | 2010 | β |
| Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes. | Murphy A et al. | β | 2010 | β |
| Maternal influences on the transmission of leukocyte gene expression profiles in population samples from Brisbane, Australia. | Mason E et al. | β | 2010 | β |
| Modeling expression quantitative trait loci in data combining ethnic populations. | Hsiao CL et al. | β | 2010 | β |
| Multigenic modeling of complex disease by random forests. | Sun YV | β | 2010 | β |
| Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families. | Glahn DC et al. | β | 2010 | β |
| New insights into the genetic control of gene expression using a Bayesian multi-tissue approach. | Petretto E et al. | β | 2010 | β |
| New loci associated with kidney function and chronic kidney disease. | KΓΆttgen A et al. | β | 2010 | β |
| Patrocles: a database of polymorphic miRNA-mediated gene regulation in vertebrates. | Hiard S et al. | β | 2010 | β |
| Polymorphic cis- and trans-regulation of human gene expression. | Cheung VG et al. | β | 2010 | β |
| Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart study. | Freedman JE et al. | β | 2010 | β |
| Simultaneous analysis of serotonin transporter, tryptophan hydroxylase 1 and 2 gene expression in the ventral prefrontal cortex of suicide victims. | Perroud N et al. | β | 2010 | β |
| STOX2 but not STOX1 is differentially expressed in decidua from pre-eclamptic women: data from the Second Nord-Trondelag Health Study. | Fenstad MH et al. | β | 2010 | β |
| Systems genetics analysis of gene-by-environment interactions in human cells. | Romanoski CE et al. | β | 2010 | β |
| The genetics of ischaemic stroke. | Matarin M et al. | β | 2010 | β |
| Transcriptome genetics using second generation sequencing in a Caucasian population. | Montgomery SB et al. | β | 2010 | β |
| Transcriptomic epidemiology of smoking: the effect of smoking on gene expression in lymphocytes. | Charlesworth JC et al. | β | 2010 | β |
| Variance component methods for analysis of complex phenotypes. | Almasy L et al. | β | 2010 | β |
| Whole brain and regional hyperintense white matter volume and blood pressure: overlap of genetic loci produced by bivariate, whole-genome linkage analyses. | Kochunov P et al. | β | 2010 | β |
| Whole-genome association mapping of gene expression in the human prefrontal cortex. | Liu C et al. | β | 2010 | β |
| XGAP: a uniform and extensible data model and software platform for genotype and phenotype experiments. | Swertz MA et al. | β | 2010 | β |
| A critical assessment of the factors affecting reporter gene assays for promoter SNP function: a reassessment of -308 TNF polymorphism function using a novel integrated reporter system. | Karimi M et al. | β | 2009 | β |
| Advances in genetical genomics of plants. | Joosen RV et al. | β | 2009 | β |
| Allele-specific gene expression is widespread across the genome and biological processes. | Palacios R et al. | β | 2009 | β |
| Allele-specific gene expression patterns in primary leukemic cells reveal regulation of gene expression by CpG site methylation. | Milani L et al. | β | 2009 | β |
| Analysis of genetic variability and whole genome linkage of whole-brain, subcortical, and ependymal hyperintense white matter volume. | Kochunov P et al. | β | 2009 | β |
| Assessing individual differences in genome-wide gene expression in human whole blood: reliability over four hours and stability over 10 months. | Meaburn EL et al. | β | 2009 | β |
| Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. | Chen SN et al. | β | 2009 | β |
| Common regulatory variation impacts gene expression in a cell type-dependent manner. | Dimas AS et al. | β | 2009 | β |
| Complex nature of SNP genotype effects on gene expression in primary human leucocytes. | Heap GA et al. | β | 2009 | β |
| Data structures and algorithms for analysis of genetics of gene expression with Bioconductor: GGtools 3.x. | Carey VJ et al. | β | 2009 | β |
| Detection and interpretation of expression quantitative trait loci (eQTL). | Michaelson JJ et al. | β | 2009 | β |
| Determinants of variation in human serum paraoxonase activity. | Rainwater DL et al. | β | 2009 | β |
| eQTL analysis in humans. | Franke L et al. | β | 2009 | β |
| Expression quantitative trait loci are highly sensitive to cellular differentiation state. | Gerrits A et al. | β | 2009 | β |
| Fluorescence intensity normalisation: correcting for time effects in large-scale flow cytometric analysis. | Dendrou CA et al. | β | 2009 | β |
| From genes to function: the next challenge to understanding multiple sclerosis. | Fugger L et al. | β | 2009 | β |
| Gene expression profiles associated with aging and mortality in humans. | Kerber RA et al. | β | 2009 | β |
| Genetic control of global gene expression levels in the intestinal mucosa: a human twin study. | HΓ€sler R et al. | β | 2009 | β |
| Genetic control of human brain transcript expression in Alzheimer disease. | Webster JA et al. | β | 2009 | β |
| Genetic predisposition to human disease: allele-specific expression and low-penetrance regulatory loci. | de la Chapelle A | β | 2009 | β |
| Genetics of human gene expression: mapping DNA variants that influence gene expression. | Cheung VG et al. | β | 2009 | β |
| Genetics of stroke. | Fornage M | β | 2009 | β |
| Genetic variation of regulatory systems. | Dimas AS et al. | β | 2009 | β |
| Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines. | Wang L et al. | β | 2009 | β |
| Genomic analysis of left ventricular remodeling. | Sarwar R et al. | β | 2009 | β |
| Genotypic analysis of gene expression in the dissection of the aetiology of complex neurological and psychiatric diseases. | Ryten M et al. | β | 2009 | β |
| Global patterns of cis variation in human cells revealed by high-density allelic expression analysis. | Ge B et al. | β | 2009 | β |
| High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. | Huang GJ et al. | β | 2009 | β |
| Human QTL linkage mapping. | Almasy L et al. | β | 2009 | β |
| Identification of brain transcriptional variation reproduced in peripheral blood: an approach for mapping brain expression traits. | Jasinska AJ et al. | β | 2009 | β |
| Identification of candidate regulatory SNPs by combination of transcription-factor-binding site prediction, SNP genotyping and haploChIP. | Ameur A et al. | β | 2009 | β |
| Inclusion of a priori information in genome-wide association analysis. | Tintle N et al. | β | 2009 | β |
| Inferring gene networks: dream or nightmare? | Baralla A et al. | β | 2009 | β |
| Inherited variation in gene expression. | Skelly DA et al. | β | 2009 | β |
| Interindividual variation in epigenomic phenomena in humans. | French HJ et al. | β | 2009 | β |
| Inter-individual variation in expression: a missing link in biomarker biology? | Little PF et al. | β | 2009 | β |
| Intra- and inter-individual genetic differences in gene expression. | Cowley MJ et al. | β | 2009 | β |
| Mapping complex disease traits with global gene expression. | Cookson W et al. | β | 2009 | β |
| Measuring cis-acting regulatory variants genome-wide: new insights into expression genetics and disease susceptibility. | Sadee W | β | 2009 | β |
| MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. | Xiong L et al. | β | 2009 | β |
| Methodological issues in molecular genetic studies of mental disorders. | Bearden CE et al. | β | 2009 | β |
| Modulated modularity clustering as an exploratory tool for functional genomic inference. | Stone EA et al. | β | 2009 | β |
| Network analysis of positional candidate genes of schizophrenia highlights myelin-related pathways. | Rietkerk T et al. | β | 2009 | β |
| Plasma lipoproteins: genetic influences and clinical implications. | Hegele RA | β | 2009 | β |
| Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13. | Plagnol V et al. | β | 2009 | β |
| Systems medicine: the future of medical genomics and healthcare. | Auffray C et al. | β | 2009 | β |
| Targeted screening of cis-regulatory variation in human haplotypes. | Verlaan DJ et al. | β | 2009 | β |
| The human Major Histocompatibility Complex as a paradigm in genomics research. | Vandiedonck C et al. | β | 2009 | β |
| TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression. | Campino S et al. | β | 2009 | β |
| Toward the identification of causal genes in complex diseases: a gene-centric joint test of significance combining genomic and transcriptomic data. | Charlesworth JC et al. | β | 2009 | β |
| Understanding quantitative genetics in the systems biology era. | Zhu M et al. | β | 2009 | β |
| A gene expression signature of confinement in peripheral blood of red wolves (Canis rufus). | Kennerly E et al. | β | 2008 | β |
| A genome-wide association study identifies protein quantitative trait loci (pQTLs). | Melzer D et al. | β | 2008 | β |
| A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan Amazighs. | Idaghdour Y et al. | β | 2008 | β |
| A linkage analysis of cigarette and alcohol consumption in an unselected Mexican American population. | Viel K et al. | β | 2008 | β |
| Approaching biomarker discovery through genomics. | Rich SS | β | 2008 | β |
| Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a Cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children. | Le Stunff C et al. | β | 2008 | β |
| A treasure trove for lipoprotein biology. | Lusis AJ et al. | β | 2008 | β |
| Blood and cardiovascular disease: the promise and limitations of gene expression analysis. | Tanriverdi K et al. | β | 2008 | β |
| Combining transcriptional profiling and genetic linkage analysis to uncover gene networks operating in hematopoietic stem cells and their progeny. | Gerrits A et al. | β | 2008 | β |
| Common variants near MC4R are associated with fat mass, weight and risk of obesity. | Loos RJ et al. | β | 2008 | β |
| Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs. | French D et al. | β | 2008 | β |
| Cross-species replication of a resistin mRNA QTL, but not QTLs for circulating levels of resistin, in human and baboon. | Tejero ME et al. | β | 2008 | β |
| Differential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression. | Serre D et al. | β | 2008 | β |
| Effect of polymorphisms within probe-target sequences on olignonucleotide microarray experiments. | Benovoy D et al. | β | 2008 | β |
| Effects of cis and trans genetic ancestry on gene expression in African Americans. | Price AL et al. | β | 2008 | β |
| eQED: an efficient method for interpreting eQTL associations using protein networks. | Suthram S et al. | β | 2008 | β |
| Expression quantitative trait locus mapping of toxoplasma genes reveals multiple mechanisms for strain-specific differences in gene expression. | Boyle JP et al. | β | 2008 | β |
| Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses. | Plagnol V et al. | β | 2008 | β |
| Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids. | Park CC et al. | β | 2008 | β |
| From gene expression to disease risk. | Dermitzakis ET | β | 2008 | β |
| Gene-environment interaction in yeast gene expression. | Smith EN et al. | β | 2008 | β |
| Gene-nutrient and gene-physical activity summary--genetics viewpoint. | Warden CH et al. | β | 2008 | β |
| Generalizing genetical genomics: getting added value from environmental perturbation. | Li Y et al. | β | 2008 | β |
| Genetic architecture of transcript-level variation in humans. | Duan S et al. | β | 2008 | β |
| Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. | Enjuanes A et al. | β | 2008 | β |
| Genome-wide association studies for complex traits: consensus, uncertainty and challenges. | McCarthy MI et al. | β | 2008 | β |
| Genome-wide co-expression analysis in multiple tissues. | Grieve IC et al. | β | 2008 | β |
| Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. | Kerkel K et al. | β | 2008 | β |
| Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer. | Valle L et al. | β | 2008 | β |
| High-resolution mapping of expression-QTLs yields insight into human gene regulation. | Veyrieras JB et al. | β | 2008 | β |
| Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. | Sankaran VG et al. | β | 2008 | β |
| Identifying the susceptibility genes for coronary artery disease: from hyperbole through doubt to cautious optimism. | Hamsten A et al. | β | 2008 | β |
| Inflammation and metabolic disorders. | Navab M et al. | β | 2008 | β |
| Insights from a rare genetic disorder of extra-skeletal bone formation, fibrodysplasia ossificans progressiva (FOP). | Shore EM et al. | β | 2008 | β |
| Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass. | Petretto E et al. | β | 2008 | β |
| Intermediate phenotypes in schizophrenia genetics redux: is it a no brainer? | Tan HY et al. | β | 2008 | β |
| Modifier effects between regulatory and protein-coding variation. | Dimas AS et al. | β | 2008 | β |
| Phenomics: building scaffolds for biological hypotheses in the post-genomic era. | Bilder RM | β | 2008 | β |
| Progress in the genetics of common obesity: size matters. | Li S et al. | β | 2008 | β |
| Protein networks in disease. | Ideker T et al. | β | 2008 | β |
| Revealing the architecture of gene regulation: the promise of eQTL studies. | Gilad Y et al. | β | 2008 | β |
| Reverse engineering the genotype-phenotype map with natural genetic variation. | Rockman MV | β | 2008 | β |
| The environmental contribution to gene expression profiles. | Gibson G | β | 2008 | β |
| The Pathway Less Traveled: Moving from Candidate Genes to Candidate Pathways in the Analysis of Genome-Wide Data from Large Scale Pharmacogenetic Association Studies. | Wilke RA et al. | β | 2008 | β |
| The value of HDL genetics. | Holleboom AG et al. | β | 2008 | β |
| Transcriptome-wide assessment of human brain and lymphocyte senescence. | Hong MG et al. | β | 2008 | β |
| Transcriptomics: new targets for diagnosing and treating cardiovascular disease. | Freedman JE | β | 2008 | β |
| Using gene expression to investigate the genetic basis of complex disorders. | Nica AC et al. | β | 2008 | β |
| Admixture mapping provides evidence of association of the VNN1 gene with hypertension. | Zhu X et al. | β | 2007 | β |