Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1.
paper
Cited
Public
- Authors
- Zheng, Wei; Long, Jirong; Gao, Yu-Tang; Li, Chun; Zheng, Ying; Xiang, Yong-Bin; Wen, Wanqing; Levy, Shawn; Deming, Sandra L; Haines, Jonathan L; Gu, Kai; Fair, Alecia Malin; Cai, Qiuyin; Lu, Wei; Shu, Xiao-Ou
- Year
- 2009
- Journal
- Nature genetics
- PMID
- 19219042
- DOI
- 10.1038/ng.318
- PMCID
- PMC2754845
We carried out a genome-wide association study among Chinese women to identify risk variants for breast cancer. After analyzing 607,728 SNPs in 1,505 cases and 1,522 controls, we selected 29 SNPs for a fast-track replication in an independent set of 1,554 cases and 1,576 controls. We further investigated four replicated loci in a third set of samples comprising 3,472 cases and 900 controls. SNP rs2046210 at 6q25.1, located upstream of the gene encoding estrogen receptor alpha (ESR1), showed strong and consistent association with breast cancer across all three stages. Adjusted odds ratio (95% CI) were 1.36 (1.24-1.49) and 1.59 (1.40-1.82), respectively, for genotypes A/G and A/A versus G/G (P for trend 2.0 x 10(-15)) in the pooled analysis of samples from all three stages. We also found a similar, albeit weaker, association in an independent study comprising 1,591 cases and 1,466 controls of European ancestry (P(trend) = 0.01). These results strongly implicate 6q25.1 as a susceptibility locus for breast cancer.
Genome-wide association results in the Shanghai Breast Cancer Study, Scatter plot of P-values in log-scale from the trend test for 607,728 genotyped SNPs comparing 1,505 cases and 1,522 controls
Regional plot of chromosome 6q25.1 locus. Results (-logP) are shown for directly genotyped (diamonds) and imputed (circles) SNPs for the region of 151.5โ152.5 Mb, flanking 500kb of SNP rs2046210. SNP rs2046210 is shown in blue. Gene locations are from the March 2006 UCSC genome browser assembly. The lower panel shows estimates of pairwise r2 for common SNPs (with MAF โฅ 5%) from the HapMap release 23a for the Asian population for the region of 151.9โ152.1 Mb, flanking 100 kb of SNP rs2046210.
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| Improved polygenic risk prediction models for breast cancer subtypes in women of African ancestry. | Li JL et al. | โ | 2026 | โ |
| Association of ESR1, HER1, and HER2 Polymorphisms with Breast Cancer Risk in the KP Population, A Case-Control Study. | Khan NU et al. | โ | 2025 | โ |
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| Exogenous Hormones, Tumor Intrinsic Subtypes, and Breast Cancer. | Le Cornet C et al. | โ | 2025 | โ |
| Genetic regulation of the estrogen receptor and inherited predisposition to breast cancer. | Pierce SB et al. | โ | 2025 | โ |
| Illuminating the Noncoding Genome in Cancer Using Artificial Intelligence. | Alvarez-Torres MDM et al. | โ | 2025 | โ |
| Insights into genetic modifiers of breast cancer risk in carriers of BRCA1 and BRCA2 pathogenic variants. | Dwornik R et al. | โ | 2025 | โ |
| Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions. | Jia G et al. | โ | 2025 | โ |
| Association of ESR1 Germline Variants with TP53 Somatic Variants in Breast Tumors in a Genome-wide Study. | Tjader NP et al. | โ | 2024 | โ |
| Gender-Specific Genetic Predisposition to Breast Cancer: <i>BRCA</i> Genes and Beyond. | Valentini V et al. | โ | 2024 | โ |
| Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction. | Jia G et al. | โ | 2024 | โ |
| Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types. | Buyukcelebi K et al. | โ | 2024 | โ |
| Novel insights into the genetic architecture of pregnancy glycemic traits from 14,744 Chinese maternities. | Zhu H et al. | โ | 2024 | โ |
| Association of the Estrogen Receptor 1 Polymorphisms rs2046210 and rs9383590 with the Risk, Age at Onset and Prognosis of Breast Cancer. | Miedl H et al. | โ | 2023 | โ |
| Comparisons of clinical characteristics, prognosis, epidemiological factors, and genetic susceptibility between HER2-low and HER2-zero breast cancer among Chinese females. | Zheng L et al. | โ | 2023 | โ |
| Identification of non-coding silencer elements and their regulation of gene expression. | Pang B et al. | โ | 2023 | โ |
| Polygenic risk scores for prediction of breast cancer in Korean women. | Jee YH et al. | โ | 2023 | โ |
| Single nucleotide polymorphisms associated with female breast cancer susceptibility in Chinese population. | Jia Z et al. | โ | 2023 | โ |
| A genome-wide gene-based gene-environment interaction study of breast cancer in more than 90,000 women. | Wang X et al. | โ | 2022 | โ |
| A robust association test with multiple genetic variants and covariates. | Lee JY et al. | โ | 2022 | โ |
| Association between Ancestry-Specific 6q25 Variants and Breast Cancer Subtypes in Peruvian Women. | Zavala VA et al. | โ | 2022 | โ |
| Distinct Reproductive Risk Profiles for Intrinsic-Like Breast Cancer Subtypes: Pooled Analysis of Population-Based Studies. | Jung AY et al. | โ | 2022 | โ |
| Evaluating breast cancer predisposition genes in women of African ancestry. | Dรญaz-Zabala H et al. | โ | 2022 | โ |
| Genome- and transcriptome-wide association studies of 386,000 Asian and European-ancestry women provide new insights into breast cancer genetics. | Jia G et al. | โ | 2022 | โ |
| Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Breast Cancer Risk Prediction Among Asian Women. | Yang Y et al. | โ | 2022 | โ |
| Lipid peroxidation biomarkers associated with height and obesity measures in the opposite direction in women. | Li M et al. | โ | 2022 | โ |
| Sequencing of Chromosomal Locus 6q25.1 Revealed Two Significant SNPs rs2046210 and rs2046211 Associated with Breast Cancer: A Case-Control Study in Egyptian Women. | Saied MH et al. | โ | 2022 | โ |
| The African Female Breast Cancer Epidemiology Study Protocol. | Ezeome ER et al. | โ | 2022 | โ |
| UACA locus is associated with breast cancer chemoresistance and survival. | Zhu Q et al. | โ | 2022 | โ |
| A Personal Breast Cancer Risk Stratification Model Using Common Variants and Environmental Risk Factors in Japanese Females. | Oze I et al. | โ | 2021 | โ |
| Association between CASC16 rs4784227 polymorphism and breast cancer susceptibility: A meta-analysis. | Liang XS et al. | โ | 2021 | โ |
| Breast Cancer-Related Low Penetrance Genes. | Kang D et al. | โ | 2021 | โ |
| Combination of a 15-SNP Polygenic Risk Score and Classical Risk Factors for the Prediction of Breast Cancer Risk in Cypriot Women. | Yiangou K et al. | โ | 2021 | โ |
| Discovery of structural deletions in breast cancer predisposition genes using whole genome sequencing data fromโ>โ2000 women of African-ancestry. | Chen Z et al. | โ | 2021 | โ |
| From <i>BRCA1</i> to Polygenic Risk Scores: Mutation-Associated Risks in Breast Cancer-Related Genes. | Woodward ER et al. | โ | 2021 | โ |
| Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies? | Park J et al. | โ | 2021 | โ |
| Genetic Regulation of Physiological Reproductive Lifespan and Female Fertility. | McGrath IM et al. | โ | 2021 | โ |
| Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium. | Marla S et al. | โ | 2021 | โ |
| Incorporating European GWAS findings improve polygenic risk prediction accuracy of breast cancer among East Asians. | Ji Y et al. | โ | 2021 | โ |
| Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Breast Cancer Risk Prediction among Asian Women, Results from Asia Breast Cancer Consortium | Yang Y et al. | โ | 2021 | โ |
| Rare Coding Variants Associated with Breast Cancer. | Han MR | โ | 2021 | โ |
| Risks and Function of Breast Cancer Susceptibility Alleles. | Torabi Dalivandan S et al. | โ | 2021 | โ |
| ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses. | Bruce JW et al. | โ | 2021 | โ |
| Applications of Next Generation Sequencing to the Analysis of Familial Breast/Ovarian Cancer. | Zelli V et al. | โ | 2020 | โ |
| CCDC170 affects breast cancer apoptosis through IRE1 pathway. | Wang Q et al. | โ | 2020 | โ |
| Critical Analysis of Genome-Wide Association Studies: Triple Negative Breast Cancer <i>Quae Exempli Causa</i>. | Jurj MA et al. | โ | 2020 | โ |
| Discovery of rare coding variants in OGDHL and BRCA2 in relation to breast cancer risk in Chinese women. | Guo X et al. | โ | 2020 | โ |
| Evaluation of pathogenetic mutations in breast cancer predisposition genes in population-based studies conducted among Chinese women. | Zeng C et al. | โ | 2020 | โ |
| Fine-mapping of a novel premenopausal breast cancer susceptibility locus at Chr4q31.22 in Caucasian women and validation in African and Chinese women. | Kumaran M et al. | โ | 2020 | โ |
| Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants. | Shu X et al. | โ | 2020 | โ |
| <i>hsa-miR-423</i> rs6505162 Is Associated with The Increased Risk of Breast Cancer in Isfahan Central Province of Iran. | Pourmoshir N et al. | โ | 2020 | โ |
| Integrative genomic analysis implicates ERCC6 and its interaction with ERCC8 in susceptibility to breast cancer. | Moslehi R et al. | โ | 2020 | โ |
| The association of single nucleotide polymorphisms (SNPs) with breast density and breast cancer survival: the Malmรถ Diet and Cancer Study. | Sartor H et al. | โ | 2020 | โ |
| Urinary bisphenol A and its interaction with ESR1 genetic polymorphism associated with non-small cell lung cancer: findings from a case-control study in Chinese population. | Li J et al. | โ | 2020 | โ |
| An <i>in silico</i> approach to characterize nonsynonymous SNPs and regulatory SNPs in human <i>TOX3</i> gene. | Akhtar M et al. | โ | 2019 | โ |
| An Interactive Resource to Probe Genetic Diversity and Estimated Ancestry in Cancer Cell Lines. | Dutil J et al. | โ | 2019 | โ |
| BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells. | Chiang HC et al. | โ | 2019 | โ |
| Evaluation of significant genome-wide association studies risk - SNPs in young breast cancer patients. | Rath M et al. | โ | 2019 | โ |
| Evidence that 6q25.1 variant rs6931104 confers susceptibility to chronic myeloid leukemia through RMND1 regulation. | Woo YM et al. | โ | 2019 | โ |
| Genetic Epidemiology of Breast Cancer in Latin America. | Zavala VA et al. | โ | 2019 | โ |
| Genetic variants in genes related to inflammation, apoptosis and autophagy in breast cancer risk. | Schuetz JM et al. | โ | 2019 | โ |
| Identification of novel common breast cancer risk variants at the 6q25 locusย among Latinas. | Hoffman J et al. | โ | 2019 | โ |
| Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population. | Low SK et al. | โ | 2019 | โ |
| Identifying breast cancer susceptibility genes - a review of the genetic background in familial breast cancer. | Wendt C et al. | โ | 2019 | โ |
| Predictive accuracy of the breast cancer genetic risk model based on eight common genetic variants: The BACkSIDE study. | Dankovรก Z et al. | โ | 2019 | โ |
| The 6q25.1 rs2046210 polymorphism is associated with an elevated susceptibility to breast cancer: A meta-analysis of 261,703 subjects. | Jin TF et al. | โ | 2019 | โ |
| A genome wide SNP genotyping study in the Tunisian population: specific reporting on a subset of common breast cancer risk loci. | Hamdi Y et al. | โ | 2018 | โ |
| A model-free test for detecting disease association signals with multiple genetic variants and covariates. | Lee JY et al. | โ | 2018 | โ |
| Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study. | Reiner AS et al. | โ | 2018 | โ |
| Capture Hi-C identifies putative target genes at 33 breast cancer risk loci. | Baxter JS et al. | โ | 2018 | โ |
| Common Genetic Variation and Breast Cancer Risk-Past, Present, and Future. | Lilyquist J et al. | โ | 2018 | โ |
| Elucidating the Underlying Functional Mechanisms of Breast Cancer Susceptibility Through Post-GWAS Analyses. | Rivandi M et al. | โ | 2018 | โ |
| Evaluating the breast cancer predisposition role of rare variants in genes associated with low-penetrance breast cancer risk SNPs. | Li N et al. | โ | 2018 | โ |
| Evaluation of three polygenic risk score models for the prediction of breast cancer risk in Singapore Chinese. | Chan CHT et al. | โ | 2018 | โ |
| Genetic Modifiers of the Breast Tumor Microenvironment. | Flister MJ et al. | โ | 2018 | โ |
| Genome-Wide Association Studies of Cancer in Diverse Populations. | Park SL et al. | โ | 2018 | โ |
| Importance of genetic background of oxysterol signaling in cancer. | Holy P et al. | โ | 2018 | โ |
| Japanese GWAS identifies variants for bust-size, dysmenorrhea, and menstrual fever that are eQTLs for relevant protein-coding or long non-coding RNAs. | Hirata T et al. | โ | 2018 | โ |
| Risk, Prediction and Prevention of Hereditary Breast Cancer - Large-Scale Genomic Studies in Times of Big and Smart Data. | Wunderle M et al. | โ | 2018 | โ |
| Update Breast Cancer 2018 (Part 3) - Genomics, Individualized Medicine and Immune Therapies - in the Middle of a New Era: Prevention and Treatment Strategies for Early Breast Cancer. | Wรถckel A et al. | โ | 2018 | โ |
| Use of deep whole-genome sequencing data to identify structure risk variants in breast cancer susceptibility genes. | Guo X et al. | โ | 2018 | โ |
| A common deletion in the haptoglobin gene associated with blood cholesterol levels among Chinese women. | Zheng NS et al. | โ | 2017 | โ |
| A functional BRCA1 coding sequence genetic variant contributes to prognosis of triple-negative breast cancer, especially after radiotherapy. | Shi M et al. | โ | 2017 | โ |
| Association between breast cancer genetic susceptibility variants and terminal duct lobular unit involution of the breast. | Bodelon C et al. | โ | 2017 | โ |
| Association of Genome-Wide Association Study (GWAS) Identified SNPs and Risk of Breast Cancer in an Indian Population. | Nagrani R et al. | โ | 2017 | โ |
| Association of three single nucleotide polymorphisms of ESR1with breast cancer susceptibility: a meta-analysis. | Hu X et al. | โ | 2017 | โ |
| Breast cancer risk-associated variants at 6q25.1 influence risk of hepatocellular carcinoma in a Chinese population. | Li J et al. | โ | 2017 | โ |
| Detecting disease association signals with multiple genetic variants and covariates. | Cheng KF et al. | โ | 2017 | โ |
| Enhanced Identification of Potential Pleiotropic Genetic Variants for Bone Mineral Density and Breast Cancer. | Peng C et al. | โ | 2017 | โ |
| ESR1 single nucleotide polymorphism rs1062577 (c.*3804T>A) alters the susceptibility of breast cancer risk in Iranian population. | Dehghan Z et al. | โ | 2017 | โ |
| Evaluating genetic variants associated with breast cancer risk in high and moderate-penetrance genes in Asians. | Han MR et al. | โ | 2017 | โ |
| Genetic variants of ESR1 and SGSM3 are associated with the susceptibility of breast cancer in the Chinese population. | Tan T et al. | โ | 2017 | โ |
| Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. | Milne RL et al. | โ | 2017 | โ |
| Impact of a Panel of 88 Single Nucleotide Polymorphisms on the Risk of Breast Cancer in High-Risk Women: Results From Two Randomized Tamoxifen Prevention Trials. | Cuzick J et al. | โ | 2017 | โ |
| Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism. | Sapkota Y et al. | โ | 2017 | โ |
| Predicting Triple-Negative Breast Cancer Subtype Using Multiple Single Nucleotide Polymorphisms for Breast Cancer Risk and Several Variable Selection Methods. | Hรคberle L et al. | โ | 2017 | โ |
| Previous GWAS hits in relation to young-onset breast cancer. | Shi M et al. | โ | 2017 | โ |
| The Protein Encoded by the CCDC170 Breast Cancer Gene Functions to Organize the Golgi-Microtubule Network. | Jiang P et al. | โ | 2017 | โ |
| Trans-ethnic predicted expression genome-wide association analysis identifies a gene for estrogen receptor-negative breast cancer. | Gao G et al. | โ | 2017 | โ |
| Using Breast Cancer Risk Associated Polymorphisms to Identify Women for Breast Cancer Chemoprevention. | Ziv E et al. | โ | 2017 | โ |
| Age at menarche and age at natural menopause in East Asian women: a genome-wide association study. | Shi J et al. | โ | 2016 | โ |
| A genome-wide association study identifies WT1 variant with better response to 5-fluorouracil, pirarubicin and cyclophosphamide neoadjuvant chemotherapy in breast cancer patients. | Wu L et al. | โ | 2016 | โ |
| Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population. | Marouf C et al. | โ | 2016 | โ |
| An Inย Vivo Gain-of-Function Screen Identifies the Williams-Beuren Syndrome Gene GTF2IRD1 as a Mammary Tumor Promoter. | Huo Y et al. | โ | 2016 | โ |
| A Review of Whole-Exome Sequencing Efforts Toward Hereditary Breast Cancer Susceptibility Gene Discovery. | Chandler MR et al. | โ | 2016 | โ |
| Association between genetic risk score for telomere length and risk of breast cancer. | Luu HN et al. | โ | 2016 | โ |
| Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21. | Hamdi Y et al. | โ | 2016 | โ |
| Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. | Dunning AM et al. | โ | 2016 | โ |
| Circulating microRNA-451 as a predictor of resistance to neoadjuvant chemotherapy in breast cancer. | Gu X et al. | โ | 2016 | โ |
| Deep targeted sequencing of 12 breast cancer susceptibility regions in 4611 women across four different ethnicities. | Lindstrรถm S et al. | โ | 2016 | โ |
| Evaluation of a newly discovered breast cancer susceptibility locus at 6q25.1 in Iranian Azari-Turkish women. | Garehdaghchi Z et al. | โ | 2016 | โ |
| Evaluation of potential regulatory function of breast cancer risk locus at 6q25.1. | Sun Y et al. | โ | 2016 | โ |
| Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus. | Horne HN et al. | โ | 2016 | โ |
| GENESIS: a French national resource to study the missing heritability of breast cancer. | Sinilnikova OM et al. | โ | 2016 | โ |
| Genetic predisposition of six well-defined polymorphisms in HMGB1/RAGE pathway to breast cancer in a large Han Chinese population. | Yue L et al. | โ | 2016 | โ |
| Genome-Wide Analysis Identifies Germ-Line Risk Factors Associated with Canine Mammary Tumours. | Melin M et al. | โ | 2016 | โ |
| Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer. | Huo D et al. | โ | 2016 | โ |
| Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. | Han MR et al. | โ | 2016 | โ |
| Genome-Wide Association Study of Bladder Cancer in a Chinese Cohort Reveals a New Susceptibility Locus at 5q12.3. | Wang M et al. | โ | 2016 | โ |
| Genomic Disparities in Breast Cancer Among Latinas. | Lynce F et al. | โ | 2016 | โ |
| Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. | Couch FJ et al. | โ | 2016 | โ |
| Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. | Zeng C et al. | โ | 2016 | โ |
| Impact of CYP19A1 and ESR1 variants on early-onset side effects during combined endocrine therapy in the TEXT trial. | Johansson H et al. | โ | 2016 | โ |
| Interactions between breast cancer susceptibility loci and menopausal hormone therapy in relationship to breast cancer in the Breast and Prostate Cancer Cohort Consortium. | Gaudet MM et al. | โ | 2016 | โ |
| Modifiers of breast and ovarian cancer risks for BRCA1 and BRCA2 mutation carriers. | Milne RL et al. | โ | 2016 | โ |
| Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer. | Bailey SD et al. | โ | 2016 | โ |
| Polymorphisms of Insulin-Like Growth Factor 1 Pathway Genes and Breast Cancer Risk. | Shi J et al. | โ | 2016 | โ |
| Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry. | Wen W et al. | โ | 2016 | โ |
| Relationship between five GWAS-identified single nucleotide polymorphisms and female breast cancer in the Chinese Han population. | He Y et al. | โ | 2016 | โ |
| rs621554 single nucleotide polymorphism of DLC1 is associated with breast cancer susceptibility and prognosis. | Ding X et al. | โ | 2016 | โ |
| Variants in 6q25.1 Are Associated with Mammographic Density in Malaysian Chinese Women. | Mariapun S et al. | โ | 2016 | โ |
| A pilot genome-wide association study of breast cancer susceptibility loci in Indonesia. | Haryono SJ et al. | โ | 2015 | โ |
| A polygenic risk score for breast cancer in women receiving tamoxifen or raloxifene on NSABP P-1 and P-2. | Vachon CM et al. | โ | 2015 | โ |
| Association of five single nucleotide polymorphisms at 6q25.1 with breast cancer risk in northwestern China. | Zhou L et al. | โ | 2015 | โ |
| Association of type 2 diabetes genetic variants with breast cancer survival among Chinese women. | Bao PP et al. | โ | 2015 | โ |
| C6ORF97-ESR1 breast cancer susceptibility locus: influence on progression and survival in breast cancer patients. | Yamamoto-Ibusuki M et al. | โ | 2015 | โ |
| Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer. | O'Mara TA et al. | โ | 2015 | โ |
| Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients. | Ronowicz A et al. | โ | 2015 | โ |
| Differences in incidence, mortality and survival of breast cancer by regions and countries in Asia and contributing factors. | Kim Y et al. | โ | 2015 | โ |
| Evaluating 17 breast cancer susceptibility loci in the Nashville breast health study. | Han MR et al. | โ | 2015 | โ |
| Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2. | Orr N et al. | โ | 2015 | โ |
| From candidate gene studies to GWAS and post-GWAS analyses in breast cancer. | Fachal L et al. | โ | 2015 | โ |
| Genetic risk variants associated with in situ breast cancer. | Campa D et al. | โ | 2015 | โ |
| Genetic variation in estrogen and progesterone pathway genes and breast cancer risk: an exploration of tumor subtype-specific effects. | Nyante SJ et al. | โ | 2015 | โ |
| Genome measures used for quality control are dependent on gene function and ancestry. | Wang J et al. | โ | 2015 | โ |
| Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. | Michailidou K et al. | โ | 2015 | โ |
| Hereditary breast cancer syndromes and genetic testing. | Rich TA et al. | โ | 2015 | โ |
| Heterogeneity of Breast Cancer Associations with Common Genetic Variants in FGFR2 according to the Intrinsic Subtypes in Southern Han Chinese Women. | Liang H et al. | โ | 2015 | โ |
| Hormone-related pathways and risk of breast cancer subtypes in African American women. | Haddad SA et al. | โ | 2015 | โ |
| Identification of two novel mammographic density loci at 6Q25.1. | Brand JS et al. | โ | 2015 | โ |
| Increased pSmad2 expression and cytoplasmic predominant presence of TGF-ฮฒRII in breast cancer tissue are associated with poor prognosis: results from the Shanghai Breast Cancer Study. | Qiu Q et al. | โ | 2015 | โ |
| Mammographic Breast Density and Common Genetic Variants in Breast Cancer Risk Prediction. | Lee CP et al. | โ | 2015 | โ |
| Putative linkage signals identified for breast cancer in African American families. | Ochs-Balcom HM et al. | โ | 2015 | โ |
| The contributions of breast density and common genetic variation to breast cancer risk. | Vachon CM et al. | โ | 2015 | โ |
| The Role of Constitutional Copy Number Variants in Breast Cancer. | Walker LC et al. | โ | 2015 | โ |
| Whole-Exome Sequencing Identifies Novel Somatic Mutations in Chinese Breast Cancer Patients. | Zhang Y et al. | โ | 2015 | โ |
| A comprehensive examination of breast cancer risk loci in African American women. | Feng Y et al. | โ | 2014 | โ |
| Additive interactions between susceptibility single-nucleotide polymorphisms identified in genome-wide association studies and breast cancer risk factors in the Breast and Prostate Cancer Cohort Consortium. | Joshi AD et al. | โ | 2014 | โ |
| A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. | Ahsan H et al. | โ | 2014 | โ |
| A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium. | Milne RL et al. | โ | 2014 | โ |
| A polymorphism rs12325489C>T in the lincRNA-ENST00000515084 exon was found to modulate breast cancer risk via GWAS-based association analyses. | Li N et al. | โ | 2014 | โ |
| A powerful association test of multiple genetic variants using a random-effects model. | Cheng KF et al. | โ | 2014 | โ |
| Association of cancer susceptibility variants with risk of multiple primary cancers: The population architecture using genomics and epidemiology study. | Park SL et al. | โ | 2014 | โ |
| Association of polymorphisms and haplotypes in the insulin-like growth factor 1 receptor (IGF1R) gene with the risk of breast cancer in Korean women. | Kang HS et al. | โ | 2014 | โ |
| Associations of two common genetic variants with breast cancer risk in a chinese population: a stratified interaction analysis. | Lin Y et al. | โ | 2014 | โ |
| Breast cancer association studies in a Han Chinese population using 10 European-ancestry-associated breast cancer susceptibility SNPs. | Guan YP et al. | โ | 2014 | โ |
| Breast cancer risk assessment using genetic variants and risk factors in a Singapore Chinese population. | Lee CP et al. | โ | 2014 | โ |
| Breast cancer subtypes and previously established genetic risk factors: a bayesian approach. | O'Brien KM et al. | โ | 2014 | โ |
| Breast cancer susceptibility variants and mammographic density phenotypes in norwegian postmenopausal women. | Ellingjord-Dale M et al. | โ | 2014 | โ |
| CHRNA9 polymorphisms and smoking exposure synergize to increase the risk of breast cancer in Taiwan. | Hsieh YC et al. | โ | 2014 | โ |
| Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium. | Milne RL et al. | โ | 2014 | โ |
| Correlates of 25-hydroxyvitamin D among Chinese breast cancer patients. | Shi L et al. | โ | 2014 | โ |
| Evaluation of functional genetic variants at 6q25.1 and risk of breast cancer in a Chinese population. | Wang Y et al. | โ | 2014 | โ |
| FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium. | Agarwal D et al. | โ | 2014 | โ |
| Functional polymorphisms in interleukin-23 receptor and susceptibility to esophageal squamous cell carcinoma in Chinese population. | Ni B et al. | โ | 2014 | โ |
| Genetic predisposition to in situ and invasive lobular carcinoma of the breast. | Sawyer E et al. | โ | 2014 | โ |
| Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes. | Villegas R et al. | โ | 2014 | โ |
| Genetic variations in the flanking regions of miR-101-2 are associated with increased risk of breast cancer. | Chen J et al. | โ | 2014 | โ |
| Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1. | Cai Q et al. | โ | 2014 | โ |
| Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians. | Zhang B et al. | โ | 2014 | โ |
| Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. | Lindstrรถm S et al. | โ | 2014 | โ |
| Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25. | Fejerman L et al. | โ | 2014 | โ |
| Germline DNA variations in breast cancer predisposition and prognosis: a systematic review of the literature. | Sapkota Y | โ | 2014 | โ |
| Improved variant calling accuracy by merging replicates in whole-exome sequencing studies. | Zhang Y et al. | โ | 2014 | โ |
| Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. | Zhang B et al. | โ | 2014 | โ |
| Nesprins in health and disease. | Cartwright S et al. | โ | 2014 | โ |
| New genetic variants improve personalized breast cancer diagnosis. | Liu J et al. | โ | 2014 | โ |
| Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. | Perry JR et al. | โ | 2014 | โ |
| Polymorphisms in ESR1 and FLJ43663 are associated with breast cancer risk in the Han population. | Xia P et al. | โ | 2014 | โ |
| Post-GWAS gene-environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79,000 women. | Barrdahl M et al. | โ | 2014 | โ |
| Rare coding variants and breast cancer risk: evaluation of susceptibility Loci identified in genome-wide association studies. | Zhang Y et al. | โ | 2014 | โ |
| Replication of breast cancer susceptibility loci in whites and African Americans using a Bayesian approach. | O'Brien KM et al. | โ | 2014 | โ |
| Risk-association of five SNPs in TOX3/LOC643714 with breast cancer in southern China. | He X et al. | โ | 2014 | โ |
| Significant overlap between human genome-wide association-study nominated breast cancer risk alleles and rat mammary cancer susceptibility loci. | Sanders J et al. | โ | 2014 | โ |
| Unmasking risk loci: DNA methylation illuminates the biology of cancer predisposition: analyzing DNA methylation of transcriptional enhancers reveals missed regulatory links between cancer risk loci and genes. | Aran D et al. | โ | 2014 | โ |
| Variants of estrogen-related genes and breast cancer risk in European and African American women. | Quan L et al. | โ | 2014 | โ |
| A common deletion in the APOBEC3 genes and breast cancer risk. | Long J et al. | โ | 2013 | โ |
| A common variant in the SIAH2 locus is associated with estrogen receptor-positive breast cancer in the Chinese Han population. | Zhang B et al. | โ | 2013 | โ |
| A genome-wide association study of breast cancer in women of African ancestry. | Chen F et al. | โ | 2013 | โ |
| An evaluation of allele frequency estimation accuracy using pooled sequencing data. | Guo Y et al. | โ | 2013 | โ |
| Assessing interactions between common genetic variant on 2q35 and hormone receptor status with breast cancer risk: evidence based on 26 studies. | Huang T et al. | โ | 2013 | โ |
| Association between a novel polymorphism (rs2046210) of the 6q25.1 locus and breast cancer risk. | Yang Z et al. | โ | 2013 | โ |
| Association of low-penetrance alleles with male breast cancer risk and clinicopathological characteristics: results from a multicenter study in Italy. | Ottini L et al. | โ | 2013 | โ |
| Associations between single-nucleotide polymorphisms and epidural ropivacaine consumption in patients undergoing breast cancer surgery. | Liu J et al. | โ | 2013 | โ |
| Breast Cancer Risk - From Genetics to Molecular Understanding of Pathogenesis. | Fasching PA et al. | โ | 2013 | โ |
| Common breast cancer risk variants in the post-COGS era: a comprehensive review. | Maxwell KN et al. | โ | 2013 | โ |
| Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. | Zheng W et al. | โ | 2013 | โ |
| Comparison of genetic variation of breast cancer susceptibility genes in Chinese and German populations. | Barzan D et al. | โ | 2013 | โ |
| Comprehensive functional annotation of seventy-one breast cancer risk Loci. | Rhie SK et al. | โ | 2013 | โ |
| Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: a case-control study in Japanese women. | Mizoo T et al. | โ | 2013 | โ |
| ESR1 single nucleotide polymorphisms predict breast cancer susceptibility in the central European Caucasian population. | Lipphardt MF et al. | โ | 2013 | โ |
| Evaluating genome-wide association study-identified breast cancer risk variants in African-American women. | Long J et al. | โ | 2013 | โ |
| Evaluation of GWAS-identified genetic variants for age at menarche among Chinese women. | Delahanty RJ et al. | โ | 2013 | โ |
| Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers. | Zheng Y et al. | โ | 2013 | โ |
| Fine-mapping of the 6q25 locus identifies a novel SNP associated with breast cancer risk in African-American women. | Ruiz-Narvรกez EA et al. | โ | 2013 | โ |
| Gene-environment interactions for breast cancer risk among Chinese women: a report from the Shanghai Breast Cancer Genetics Study. | Li H et al. | โ | 2013 | โ |
| Genetic analysis of common variants in the CMYA5 (cardiomyopathy-associated 5) gene with schizophrenia. | Zhang R et al. | โ | 2013 | โ |
| Genetic ancestry modifies the association between genetic risk variants and breast cancer risk among Hispanic and non-Hispanic white women. | Fejerman L et al. | โ | 2013 | โ |
| Genetic susceptibility loci for subtypes of breast cancer in an African American population. | Palmer JR et al. | โ | 2013 | โ |
| Genetic susceptibility to triple-negative breast cancer. | Stevens KN et al. | โ | 2013 | โ |
| Genetic variants associated with breast cancer risk for Ashkenazi Jewish women with strong family histories but no identifiable BRCA1/2 mutation. | Rinella ES et al. | โ | 2013 | โ |
| Genetic variants at 12p11 and 12q24 are associated with breast cancer risk in a Chinese population. | Qin Z et al. | โ | 2013 | โ |
| Genetic variants improve breast cancer risk prediction on mammograms. | Liu J et al. | โ | 2013 | โ |
| Genetic variants in hormone-related genes and risk of breast cancer. | Clendenen T et al. | โ | 2013 | โ |
| Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. | Jiang DK et al. | โ | 2013 | โ |
| Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women. | Lee E et al. | โ | 2013 | โ |
| Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. | Jia WH et al. | โ | 2013 | โ |
| Genome-wide association study of breast cancer in the Japanese population. | Low SK et al. | โ | 2013 | โ |
| Hereditary breast cancer: ever more pieces to the polygenic puzzle. | Bogdanova N et al. | โ | 2013 | โ |
| Hereditary breast cancer: the era of new susceptibility genes. | Apostolou P et al. | โ | 2013 | โ |
| Hereditary genes and SNPs associated with breast cancer. | Mahdi KM et al. | โ | 2013 | โ |
| Identification of a breast cancer susceptibility locus at 4q31.22 using a genome-wide association study paradigm. | Sapkota Y et al. | โ | 2013 | โ |
| Inherited genetic susceptibility to breast cancer: the beginning of the end or the end of the beginning? | Ghoussaini M et al. | โ | 2013 | โ |
| Interaction of cigarette smoking and carcinogen-metabolizing polymorphisms in the risk of colorectal polyps. | Fu Z et al. | โ | 2013 | โ |
| Large-scale genotyping identifies 41 new loci associated with breast cancer risk. | Michailidou K et al. | โ | 2013 | โ |
| Male breast cancer: genetics, epigenetics, and ethical aspects. | Rizzolo P et al. | โ | 2013 | โ |
| Mapping of three genetic determinants of susceptibility to estrogen-induced mammary cancer within the Emca8 locus on rat chromosome 5. | Schaffer BS et al. | โ | 2013 | โ |
| New breast cancer risk variant discovered at 10q25 in East Asian women. | Shi J et al. | โ | 2013 | โ |
| No association between genetic variants in angiogenesis and inflammation pathway genes and breast cancer survival among Chinese women. | Dorjgochoo T et al. | โ | 2013 | โ |
| No association between ovarian cancer susceptibility variants and breast cancer risk among Chinese women. | Ma X et al. | โ | 2013 | โ |
| Polymorphisms in inflammation pathway genes and endometrial cancer risk. | Delahanty RJ et al. | โ | 2013 | โ |
| Quantitative assessment of 2q35-rs13387042 polymorphism and hormone receptor status with breast cancer risk. | Gu C et al. | โ | 2013 | โ |
| Quantitative assessment of the association between rs2046210 at 6q25.1 and breast cancer risk. | Wu X et al. | โ | 2013 | โ |
| Risk of GWAS-identified genetic variants for breast cancer in a Chinese population: a multiple interaction analysis. | Chen W et al. | โ | 2013 | โ |
| Single nucleotide polymorphism 6q25.1 rs2046210 and increased risk of breast cancer. | Pei J et al. | โ | 2013 | โ |
| The associations between a polygenic score, reproductive and menstrual risk factors and breast cancer risk. | Warren Andersen S et al. | โ | 2013 | โ |
| The gene desert mammary carcinoma susceptibility locus Mcs1a regulates Nr2f1 modifying mammary epithelial cell differentiation and proliferation. | Smits BM et al. | โ | 2013 | โ |
| The relationship between eight GWAS-identified single-nucleotide polymorphisms and primary breast cancer outcomes. | Bayraktar S et al. | โ | 2013 | โ |
| 9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium. | Warren H et al. | โ | 2012 | โ |
| A common polymorphism near the ESR1 gene is associated with risk of breast cancer: evidence from a case-control study and a meta-analysis. | Guo H et al. | โ | 2012 | โ |
| Admixture mapping identifies a locus on 6q25 associated with breast cancer risk in US Latinas. | Fejerman L et al. | โ | 2012 | โ |
| A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population. | Sueta A et al. | โ | 2012 | โ |
| A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study. | Kim HC et al. | โ | 2012 | โ |
| A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. | Siddiq A et al. | โ | 2012 | โ |
| An insulator loop resides between the synthetically interacting elements of the human/rat conserved breast cancer susceptibility locus MCS5A/Mcs5a. | Smits BM et al. | โ | 2012 | โ |
| A polymorphism in the nuclear receptor coactivator 7 gene and breast cancer susceptibility. | Sรผllner J et al. | โ | 2012 | โ |
| Assessing individual breast cancer risk within the U.K. National Health Service Breast Screening Program: a new paradigm for cancer prevention. | Evans DG et al. | โ | 2012 | โ |
| Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population. | Chan M et al. | โ | 2012 | โ |
| Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2. | Kirchhoff T et al. | โ | 2012 | โ |
| Breast cancer risk assessment with five independent genetic variants and two risk factors in Chinese women. | Dai J et al. | โ | 2012 | โ |
| Breast cancer risk prediction and individualised screening based on common genetic variation and breast density measurement. | Darabi H et al. | โ | 2012 | โ |
| Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed. | Hsu YH et al. | โ | 2012 | โ |
| Combined effect of low-penetrant SNPs on breast cancer risk. | Harlid S et al. | โ | 2012 | โ |
| Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk. | Vachon CM et al. | โ | 2012 | โ |
| Common genetic variants in the microRNA biogenesis pathway are not associated with breast cancer risk in Asian women. | Sung H et al. | โ | 2012 | โ |
| Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC). | Hein R et al. | โ | 2012 | โ |
| Comprehensive genomic studies: emerging regulatory, strategic, and quality assurance challenges for biorepositories. | McDonald SA et al. | โ | 2012 | โ |
| Estimating causal effects of genetic risk variants for breast cancer using marker data from bilateral and familial cases. | Dudbridge F et al. | โ | 2012 | โ |
| Estrogen receptor alpha gene variants are associated with Alzheimer's disease. | Boada M et al. | โ | 2012 | โ |
| Estrogen receptors and human disease: an update. | Burns KA et al. | โ | 2012 | โ |
| Evaluation of 19 susceptibility loci of breast cancer in women of African ancestry. | Huo D et al. | โ | 2012 | โ |
| Evaluation of association methods for analysing modifiers of disease risk in carriers of high-risk mutations. | Barnes DR et al. | โ | 2012 | โ |
| Exome sequencing generates high quality data in non-target regions. | Guo Y et al. | โ | 2012 | โ |
| Familial breast cancer. | Lalloo F et al. | โ | 2012 | โ |
| FGFR2 genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma. | Ma YP et al. | โ | 2012 | โ |
| Functional genetic variations in the IL-23 receptor gene are associated with risk of breast, lung and nasopharyngeal cancer in Chinese populations. | Zheng J et al. | โ | 2012 | โ |
| Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706. | Zhang R et al. | โ | 2012 | โ |
| Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes. | Nagel JH et al. | โ | 2012 | โ |
| Genetic variants at chromosome 9p21, 10p15 and 10q22 and breast cancer susceptibility in a Chinese population. | Chen J et al. | โ | 2012 | โ |
| Genetic variants in vitamin D metabolism-related genes and body mass index: analysis of genome-wide scan data of approximately 7000 Chinese women. | Dorjgochoo T et al. | โ | 2012 | โ |
| Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in Singapore Chinese women. | Lee E et al. | โ | 2012 | โ |
| Genome-wide association analysis identifies three new breast cancer susceptibility loci. | Ghoussaini M et al. | โ | 2012 | โ |
| Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians. | Shan J et al. | โ | 2012 | โ |
| Genome-wide association study identifies a possible susceptibility locus for endometrial cancer. | Long J et al. | โ | 2012 | โ |
| Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4. | Xu J et al. | โ | 2012 | โ |
| Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer. | Long J et al. | โ | 2012 | โ |
| Genome-wide methylation profiling in archival formalin-fixed paraffin-embedded tissue samples. | Killian JK et al. | โ | 2012 | โ |
| Genomic profiling: cDNA arrays and oligoarrays. | Gorreta F et al. | โ | 2012 | โ |
| Identification of genetic and non-genetic risk factors for nasopharyngeal carcinoma in a Southeast Asian population. | Nor Hashim NA et al. | โ | 2012 | โ |
| Joint effect of genetic and lifestyle risk factors on type 2 diabetes risk among Chinese men and women. | Villegas R et al. | โ | 2012 | โ |
| Melatonin pathway genes and breast cancer risk among Chinese women. | Deming SL et al. | โ | 2012 | โ |
| Microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes and breast cancer risk in African American and Nigerian women. | Zheng Y et al. | โ | 2012 | โ |
| Novel genetic markers of breast cancer survival identified by a genome-wide association study. | Shu XO et al. | โ | 2012 | โ |
| Oncogenomics methods and resources. | Furney SJ et al. | โ | 2012 | โ |
| Pathway analyses identify TGFBR2 as potential breast cancer susceptibility gene: results from a consortium study among Asians. | Ma X et al. | โ | 2012 | โ |
| Prediction of breast cancer risk by genetic risk factors, overall and by hormone receptor status. | Hรผsing A et al. | โ | 2012 | โ |
| Prevention of breast cancer in the context of a national breast screening programme. | Howell A et al. | โ | 2012 | โ |
| Race and the molecular origins of breast cancer in Chinese women: breast cancer in Chinese women. | Chen M et al. | โ | 2012 | โ |
| Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene. | denDekker AD et al. | โ | 2012 | โ |
| Replication study for reported SNP associations with breast cancer survival. | Beeghly-Fadiel A et al. | โ | 2012 | โ |
| Steps to ensure accuracy in genotype and SNP calling from Illumina sequencing data. | Liu Q et al. | โ | 2012 | โ |
| Susceptibility loci affecting ERBB2/neu-induced mammary tumorigenesis in mice. | Quan L et al. | โ | 2012 | โ |
| The effect of strand bias in Illumina short-read sequencing data. | Guo Y et al. | โ | 2012 | โ |
| The pharmacogenomics of sex hormone metabolism: breast cancer risk in menopausal hormone therapy. | Justenhoven C et al. | โ | 2012 | โ |
| The SLC4A7 variant rs4973768 is associated with breast cancer risk: evidence from a case-control study and a meta-analysis. | Chen W et al. | โ | 2012 | โ |
| Unravelling modifiers of breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: update on genetic modifiers. | Barnes DR et al. | โ | 2012 | โ |
| Using gene-environment interaction analyses to clarify the role of well-done meat and heterocyclic amine exposure in the etiology of colorectal polyps. | Fu Z et al. | โ | 2012 | โ |
| Ability to predict breast cancer in Asian women using a polygenic susceptibility model. | Hartman M et al. | โ | 2011 | โ |
| A candidate CpG SNP approach identifies a breast cancer associated ESR1-SNP. | Harlid S et al. | โ | 2011 | โ |
| A combined analysis of genome-wide association studies in breast cancer. | Li J et al. | โ | 2011 | โ |
| A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence. | Vazquez A et al. | โ | 2011 | โ |
| A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia. | Kim DH et al. | โ | 2011 | โ |
| A genome-wide linkage study of mammographic density, a risk factor for breast cancer. | Greenwood CM et al. | โ | 2011 | โ |
| A multistage association study identifies a breast cancer genetic locus at NCOA7. | Higginbotham KS et al. | โ | 2011 | โ |
| Association of a single nucleotide polymorphism at 6q25.1,rs2046210, with endometrial cancer risk among Chinese women. | Li G et al. | โ | 2011 | โ |
| Association of obesity-related genetic variants with endometrial cancer risk: a report from the Shanghai Endometrial Cancer Genetics Study. | Delahanty RJ et al. | โ | 2011 | โ |
| Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium. | Figueroa JD et al. | โ | 2011 | โ |
| Cancer evolution and individual susceptibility. | Pรฉrez-Losada J et al. | โ | 2011 | โ |
| Caution in generalizing known genetic risk markers for breast cancer across all ethnic/racial populations. | Chen F et al. | โ | 2011 | โ |
| Chromatin architecture and the regulation of nuclear receptor inducible transcription. | Biddie SC | โ | 2011 | โ |
| Clinical trials in the era of personalized oncology. | Maitland ML et al. | โ | 2011 | โ |
| Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers. | Antoniou AC et al. | โ | 2011 | โ |
| Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2. | Mulligan AM et al. | โ | 2011 | โ |
| Common breast cancer susceptibility loci are associated with triple-negative breast cancer. | Stevens KN et al. | โ | 2011 | โ |
| Common genetic variants associated with breast cancer in Korean women and differential susceptibility according to intrinsic subtype. | Han W et al. | โ | 2011 | โ |
| Composite likelihood-based meta-analysis of breast cancer association studies. | Politopoulos I et al. | โ | 2011 | โ |
| Current status of genome-wide association studies in cancer. | Chung CC et al. | โ | 2011 | โ |
| Detection of chromosomal abnormalities using high resolution arrays in clinical cancer research. | Dalmasso C et al. | โ | 2011 | โ |
| ESR1 is co-expressed with closely adjacent uncharacterised genes spanning a breast cancer susceptibility locus at 6q25.1. | Dunbier AK et al. | โ | 2011 | โ |
| Estrogen receptor-positive breast cancer in Japanese women: trends in incidence, characteristics, and prognosis. | Yamashita H et al. | โ | 2011 | โ |
| Evaluation of functional genetic variants for breast cancer risk: results from the Shanghai breast cancer study. | Zhang B et al. | โ | 2011 | โ |
| Evaluation of polygenic risk scores for predicting breast and prostate cancer risk. | Machiela MJ et al. | โ | 2011 | โ |
| Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans. | Chen F et al. | โ | 2011 | โ |
| Genetic modifiers of cancer risk for BRCA1 and BRCA2 mutation carriers. | Milne RL et al. | โ | 2011 | โ |
| Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies. | Peng S et al. | โ | 2011 | โ |
| Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. | Zhang B et al. | โ | 2011 | โ |
| Genetic variants at 1p11.2 and breast cancer risk: a two-stage study in Chinese women. | Jiang Y et al. | โ | 2011 | โ |
| Genetic variants of 6q25 and breast cancer susceptibility: a two-stage fine mapping study in a Chinese population. | Han J et al. | โ | 2011 | โ |
| Genetic variation in VEGF family genes and breast cancer risk: a report from the Shanghai Breast Cancer Genetics Study. | Beeghly-Fadiel A et al. | โ | 2011 | โ |
| Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer. | Li Y et al. | โ | 2011 | โ |
| Genome-based prediction of breast cancer risk in the general population: a modeling study based on meta-analyses of genetic associations. | van Zitteren M et al. | โ | 2011 | โ |
| Genome-wide association studies for detecting cancer susceptibility. | Hosking FJ et al. | โ | 2011 | โ |
| Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium. | Cai Q et al. | โ | 2011 | โ |
| Identifying highly conserved and highly differentiated gene ontology categories in human populations. | Jiang Y et al. | โ | 2011 | โ |
| Inherited mutations in breast cancer genes--risk and response. | Shuen AY et al. | โ | 2011 | โ |
| Integrated analysis of gene expression, CpG island methylation, and gene copy number in breast cancer cells by deep sequencing. | Sun Z et al. | โ | 2011 | โ |
| Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium. | Campa D et al. | โ | 2011 | โ |
| Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. | Broeks A et al. | โ | 2011 | โ |
| Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression. | Veillet AL et al. | โ | 2011 | โ |
| MMP9 polymorphisms and breast cancer risk: a report from the Shanghai Breast Cancer Genetics Study. | Beeghly-Fadiel A et al. | โ | 2011 | โ |
| Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families. | Johnson J et al. | โ | 2011 | โ |
| Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. | Fletcher O et al. | โ | 2011 | โ |
| Peroxisome proliferator-activated receptor delta (PPARD) genetic variation and type 2 diabetes in middle-aged Chinese women. | Villegas R et al. | โ | 2011 | โ |
| Polygenic susceptibility to prostate and breast cancer: implications for personalised screening. | Pashayan N et al. | โ | 2011 | โ |
| Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility. | Sehrawat B et al. | โ | 2011 | โ |
| RAD51C is a susceptibility gene for ovarian cancer. | Pelttari LM et al. | โ | 2011 | โ |
| [Recent progress in genetic variants associated with cancer and their implications in diagnostics development]. | Cho WC | โ | 2011 | โ |
| Relation of FGFR2 genetic polymorphisms to the association between oral contraceptive use and the risk of breast cancer in Chinese women. | Xu WH et al. | โ | 2011 | โ |
| Replication and functional genomic analyses of the breast cancer susceptibility locus at 6q25.1 generalize its importance in women of chinese, Japanese, and European ancestry. | Cai Q et al. | โ | 2011 | โ |
| Replication of breast cancer GWAS susceptibility loci in the Women's Health Initiative African American SHARe Study. | Hutter CM et al. | โ | 2011 | โ |
| Replication of genome-wide discovered breast cancer risk loci in the Cypriot population. | Loizidou MA et al. | โ | 2011 | โ |
| Replication of GWAS "Hits" by Race for Breast and Prostate Cancers in European Americans and African Americans. | Barnholtz-Sloan JS et al. | โ | 2011 | โ |
| Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province. | Jiang Y et al. | โ | 2011 | โ |
| Selected estrogen receptor 1 and androgen receptor gene polymorphisms in relation to risk of breast cancer and fibrocystic breast conditions among Chinese women. | Sakoda LC et al. | โ | 2011 | โ |
| The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions. | Smits BM et al. | โ | 2011 | โ |
| Accurate SNP and mutation detection by targeted custom microarray-based genomic enrichment of short-fragment sequencing libraries. | Mokry M et al. | โ | 2010 | โ |
| A compendium of genome-wide associations for cancer: critical synopsis and reappraisal. | Ioannidis JP et al. | โ | 2010 | โ |
| A genome-wide association scan on estrogen receptor-negative breast cancer. | Li J et al. | โ | 2010 | โ |
| Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus. | Stacey SN et al. | โ | 2010 | โ |
| Association of rare MSH6 variants with familial breast cancer. | Wasielewski M et al. | โ | 2010 | โ |
| Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer. | Galvan A et al. | โ | 2010 | โ |
| Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction. | Antoniou AC et al. | โ | 2010 | โ |
| Common genetic variants and cancer risk in Mendelian cancer syndromes. | Antoniou AC et al. | โ | 2010 | โ |
| Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. | Wang X et al. | โ | 2010 | โ |
| Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. | Canzian F et al. | โ | 2010 | โ |
| Current evidence on the relationship between polymorphisms in the COX-2 gene and breast cancer risk: a meta-analysis. | Yu KD et al. | โ | 2010 | โ |
| Distribution of FGFR2, TNRC9, MAP3K1, LSP1, and 8q24 alleles in genetically enriched breast cancer patients versus elderly tumor-free women. | Gorodnova TV et al. | โ | 2010 | โ |
| Diverse associations between ESR1 polymorphism and breast cancer development and progression. | Ding SL et al. | โ | 2010 | โ |
| E-cadherin polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer Study. | Beeghly-Fadiel A et al. | โ | 2010 | โ |
| ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study. | Doherty JA et al. | โ | 2010 | โ |
| Estrogens, regulation of p53 and breast cancer risk: a balancing act. | Jerry DJ et al. | โ | 2010 | โ |
| Evaluation of breast cancer susceptibility loci in Chinese women. | Long J et al. | โ | 2010 | โ |
| Evaluation of genetic susceptibility loci for obesity in Chinese women. | Shi J et al. | โ | 2010 | โ |
| Exploring genetic susceptibility to cancer in diverse populations. | Haiman CA et al. | โ | 2010 | โ |
| Exploring the link between germline and somatic genetic alterations in breast carcinogenesis. | Bonifaci N et al. | โ | 2010 | โ |
| Familial relative risks for breast cancer by pathological subtype: a population-based cohort study. | Mavaddat N et al. | โ | 2010 | โ |
| FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women. | Barnholtz-Sloan JS et al. | โ | 2010 | โ |
| Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study. | Travis RC et al. | โ | 2010 | โ |
| Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women. | Zheng W et al. | โ | 2010 | โ |
| Genetic contribution of GADD45A to susceptibility to sporadic and non-BRCA1/2 familial breast cancers: a systematic evaluation in Chinese populations. | Yu KD et al. | โ | 2010 | โ |
| Genetic risk information for common diseases may indeed be already useful for prevention and early detection. | Gulcher J et al. | โ | 2010 | โ |
| Genetic susceptibility to breast cancer. | Mavaddat N et al. | โ | 2010 | โ |
| Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women. | Lin J et al. | โ | 2010 | โ |
| Genome-wide association studies in cancer--current and future directions. | Chung CC et al. | โ | 2010 | โ |
| Genome-wide association studies in common cancers--what have we learnt? | Varghese JS et al. | โ | 2010 | โ |
| Genome-wide association studies of cancer. | Stadler ZK et al. | โ | 2010 | โ |
| Genome-wide association studies of cancer predisposition. | Stadler ZK et al. | โ | 2010 | โ |
| Genome-wide association study identifies five new breast cancer susceptibility loci. | Turnbull C et al. | โ | 2010 | โ |
| Genome-wide mechanisms of nuclear receptor action. | Biddie SC et al. | โ | 2010 | โ |
| Genomic analyses of hormone signaling and gene regulation. | Cheung E et al. | โ | 2010 | โ |
| GPR30 gene polymorphisms are associated with progesterone receptor status and histopathological characteristics of breast cancer patients. | Giess M et al. | โ | 2010 | โ |
| Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium. | Long J et al. | โ | 2010 | โ |
| Identification of new genetic risk variants for type 2 diabetes. | Shu XO et al. | โ | 2010 | โ |
| Leveraging genetic variability across populations for the identification of causal variants. | Zaitlen N et al. | โ | 2010 | โ |
| Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls. | Fletcher O et al. | โ | 2010 | โ |
| Mutation and association analysis of GEN1 in breast cancer susceptibility. | Turnbull C et al. | โ | 2010 | โ |
| No association between a progesterone receptor gene promoter polymorphism (+331G>A) and breast cancer risk in Caucasian women: evidence from a literature-based meta-analysis. | Yu KD et al. | โ | 2010 | โ |
| Pathway analysis of breast cancer genome-wide association study highlights three pathways and one canonical signaling cascade. | Menashe I et al. | โ | 2010 | โ |
| Personalized medicine: marking a new epoch in cancer patient management. | Diamandis M et al. | โ | 2010 | โ |
| Potentially functional polymorphisms in ESR1 and breast cancer risk: a meta-analysis. | Li N et al. | โ | 2010 | โ |
| Recent progress in genetic variants associated with cancer and their implications in diagnostics development. | Cho WC | โ | 2010 | โ |
| Search for cancer risk factors with microarray-based genome-wide association studies. | Zhang L et al. | โ | 2010 | โ |
| The influence of common polymorphisms on breast cancer. | Eccles D et al. | โ | 2010 | โ |
| The pursuit of genome-wide association studies: where are we now? | Ku CS et al. | โ | 2010 | โ |
| Two-stage case-control study of DNMT-1 and DNMT-3B gene variants and breast cancer risk. | Ye C et al. | โ | 2010 | โ |
| Breast cancer single-nucleotide polymorphisms: statistical significance and clinical utility. | Offit K | โ | 2009 | โ |
| Evaluation of 11 breast cancer susceptibility loci in African-American women. | Zheng W et al. | โ | 2009 | โ |
| Finding the missing heritability of complex diseases. | Manolio TA et al. | โ | 2009 | โ |
| Human genetic variations: Beacons on the pathways to successful ageing. | Cluett C et al. | โ | 2009 | โ |
| Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. | Ahmed S et al. | โ | 2009 | โ |
| Polygenic susceptibility to breast cancer: current state-of-the-art. | Ghoussaini M et al. | โ | 2009 | โ |
| Sequence and structure signatures of cancer mutation hotspots in protein kinases. | Dixit A et al. | โ | 2009 | โ |
| Technologies in the Whole-Genome Age: MALDI-TOF-Based Genotyping. | Vogel N et al. | โ | 2009 | โ |
| Update on genetic predisposition to breast cancer. | Ahmed M et al. | โ | 2009 | โ |