Vitamin A and iron supplementation is as efficient as hormonal therapy in constitutionally delayed children.
OBJECTIVE: To assess the effect of nutritional supplementation on growth and puberty in constitutionally delayed children. PATIENTS: One hundred and two boys, 13.6-15.5 years of age, who were referred because of short stature and delayed puberty. METHODS: The boys were randomly allocated to one of the following treatment groups: oxandrolone therapy, 5 mg/day for 6 months (n = 15), testosterone depot, 100 mg monthly for 3 months (n = 15) or for 6 months (n = 20), nutritional programme (n = 17), oxandrolone and nutritional programme (n = 15) or passive observation (n = 20). Boys in the nutritional programmes received 12 mg/day iron and 6000 IU/week of vitamin A. Outcome measurements were of height, weight, pubertal signs, dietary intake, serum vitamin A, iron, GH and IGF-1. RESULTS: Six months of vitamin A supplementation induced growth acceleration similar to that seen in the oxandrolone- and testosterone-treated children, and significantly greater than in the observation group (9.3 +/- 2.9 vs. 4.0 +/- 0.9 crn/yr, P < 0.001). Whereas in the vitamin A-supplemented group, puberty (increase in testicular volume >/= 12 ml) was induced within 12 months. In all testosterone-treated patients, pubic hair was noted within 3 months and a testicular volume of >/= 12 ml was observed 9-12 months after the initiation of therapy. No pubertal signs were noted in the observation group during this time. CONCLUSIONS: Subnormal vitamin A intake is one of the aetiological factors in delayed pubertal maturation. Supplementation of both vitamin A and iron to normal constitutionally delayed children with subnormal vitamin A intake is as efficacious as hormonal therapy in the induction of growth and puberty.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. | 2014 | 25231870 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Vitamin A supplementation during the suckling period attenuates the effects of a maternal Western diet on liver sexual maturity-related traits in a sex-dependent manner. | Abrego-Guandique DM et al. | — | 2026 | → |
| Review Nutritional interventions during adolescence and their possible effects. | Soliman AT et al. | — | 2022 | → |
| A Clinical Study on the Treatment of Children's Short Stature with Auxiliary Comprehensive Management Combined with Growth Patch. | Feng H et al. | — | 2021 | → |
| A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder. | Sarohan AR et al. | — | 2021 | → |
| Reduced Final Height and Inadequate Nutritional Intake in Cow's Milk-Allergic Young Adults. | Sinai T et al. | — | 2019 | → |
| The Impact of Nutritional Interventions beyond the First 2 Years of Life on Linear Growth: A Systematic Review and Meta-Analysis. | Roberts JL et al. | — | 2017 | → |
| The vicious cycle of vitamin a deficiency: A review. | Wiseman EM et al. | — | 2017 | → |
| Nutritional Determinants of the Timing of Puberty. | Villamor E et al. | — | 2016 | → |
| Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. | Perry JR et al. | — | 2014 | → |
| Vitamins and trace elements are important for the integrity of the endocrine system. | Zadik Z | — | 2009 | → |