Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.
paper
Cited
Public
Unavailable
- Authors
- Barreiro, Luis B; Tailleux, Ludovic; Pai, Athma A; Gicquel, Brigitte; Marioni, John C; Gilad, Yoav
- Year
- 2012
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 22233810
- DOI
- 10.1073/pnas.1115761109
- PMCID
- PMC3268270
Tuberculosis (TB) is a major public health problem. One-third of the world's population is estimated to be infected with Mycobacterium tuberculosis (MTB), the etiological agent causing TB, and active disease kills nearly 2 million individuals worldwide every year. Several lines of evidence indicate that interindividual variation in susceptibility to TB has a heritable component, yet we still know little about the underlying genetic architecture. To address this, we performed a genome-wide mapping study of loci that are associated with functional variation in immune response to MTB. Specifically, we characterized transcript and protein expression levels and mapped expression quantitative trait loci (eQTL) in primary dendritic cells (DCs) from 65 individuals, before and after infection with MTB. We found 198 response eQTL, namely loci that were associated with variation in gene expression levels in either untreated or MTB-infected DCs, but not both. These response eQTL are associated with natural regulatory variation that likely affects (directly or indirectly) host interaction with MTB. Indeed, when we integrated our data with results from a genome-wide association study (GWAS) for pulmonary TB, we found that the response eQTL were more likely to be genetically associated with the disease. We thus identified a number of candidate loci, including the MAPK phosphatase DUSP14 in particular, that are promising susceptibility genes to pulmonary TB.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. | 2014 | 25231870 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Analysis of Key miRNA/mRNA Functional Axes During Host Dendritic Cell Immune Response to <i>Mycobacterium tuberculosis</i> Based on GEO Datasets. | Gao Q et al. | β | 2025 | β |
| Gene expression QTL mapping in stimulated iPSC-derived macrophages provides insights into common complex diseases. | Panousis NI et al. | β | 2025 | β |
| Genetic modulation of protein expression in rat brain. | Li L et al. | β | 2025 | β |
| Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability. | Sadee W et al. | β | 2025 | β |
| Integrative genomics sheds light on the immunogenetics of tuberculosis in cattle. | O'Grady JF et al. | β | 2025 | β |
| Modeling heterogeneity in single-cell perturbation states enhances detection of response eQTLs. | Valencia C et al. | β | 2025 | β |
| Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoids. | Umans BD et al. | β | 2025 | β |
| Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes. | Harigaya Y et al. | β | 2025 | β |
| Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk. | Kramer NE et al. | β | 2025 | β |
| Tensor decomposition reveals trans-regulated gene modules in maize drought response. | Lu J et al. | β | 2025 | β |
| Characterization of caffeine response regulatory variants in vascular endothelial cells. | Boye C et al. | β | 2024 | β |
| Epigenetic variation impacts individual differences in the transcriptional response to influenza infection. | Aracena KA et al. | β | 2024 | β |
| GenotypeβΓβenvironment interactions in gene regulation and complex traits. | Boye C et al. | β | 2024 | β |
| History of tuberculosis disease is associated with genetic regulatory variation in Peruvians. | Nieto-Caballero VE et al. | β | 2024 | β |
| <i>Mycobacterium tuberculosis</i>-dependent monocyte expression quantitative trait loci, cytokine production, and TB pathogenesis. | Hong H et al. | β | 2024 | β |
| Multi-omic characterization of allele-specific regulatory variation in hybrid pigs. | Quan J et al. | β | 2024 | β |
| Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity. | Moorlag SJCFM et al. | β | 2024 | β |
| Shaping immunity: The influence of natural selection on population immune diversity. | Randolph HE et al. | β | 2024 | β |
| Variants in the <i>N</i>-acetyltranferase 2 gene, acetylator phenotypes and their association with tuberculosis: Findings in Peruvian patients. | SΓ‘nchez R et al. | β | 2024 | β |
| Analysis of transcriptional changes in the immune system associated with pubertal development in a longitudinal cohort of children with asthma. | Resztak JA et al. | β | 2023 | β |
| Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS. | Nehar-Belaid D et al. | β | 2023 | β |
| Genetic control of the dynamic transcriptional response to immune stimuli and glucocorticoids at single-cell resolution. | Resztak JA et al. | β | 2023 | β |
| Genome graphs detect human polymorphisms in active epigenomic state during influenza infection. | Groza C et al. | β | 2023 | β |
| Human variation impacting <i>MCOLN2</i> restricts <i>Salmonella</i> Typhi replication by magnesium deprivation. | Gibbs KD et al. | β | 2023 | β |
| Leveraging drug perturbation to reveal genetic regulators of hepatic gene expression in African Americans. | Zhong Y et al. | β | 2023 | β |
| meQTL mapping in the GENOA study reveals genetic determinants of DNA methylation in African Americans. | Shang L et al. | β | 2023 | β |
| Methods and Insights from Single-Cell Expression Quantitative Trait Loci. | Kang JB et al. | β | 2023 | β |
| Mycobacterium tuberculosis Gene Expression Associated With Fluoroquinolone Resistance and Efflux Pump Inhibition. | van der Heijden YF et al. | β | 2023 | β |
| Tuberculosis severity associates with variants and eQTLs related to vascular biology and infection-induced inflammation. | McHenry ML et al. | β | 2023 | β |
| Using epigenomics to understand cellular responses to environmental influences in diseases. | Wattacheril JJ et al. | β | 2023 | β |
| Characterization of caffeine response regulatory variants in vascular endothelial cells | Boye C et al. | β | 2022 | β |
| Diverse environmental perturbations reveal the evolution and context-dependency of genetic effects on gene expression levels. | Lea AJ et al. | β | 2022 | β |
| Functional Characterization of Genetic Variant Effects on Expression. | Flynn ED et al. | β | 2022 | β |
| Glucocorticoids unmask silent non-coding genetic risk variants for common diseases. | Nguyen TTL et al. | β | 2022 | β |
| REL and BHLHE40 Variants Are Associated with IL-12 and IL-10 Responses and Tuberculosis Risk. | Shah JA et al. | β | 2022 | β |
| Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure. | Oelen R et al. | β | 2022 | β |
| TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and <i>Mycobacterium tuberculosis</i>. | Venkatasubramanian S et al. | β | 2022 | β |
| An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation? | Brandt M et al. | β | 2021 | β |
| A signature of Neanderthal introgression on molecular mechanisms of environmental responses. | Findley AS et al. | β | 2021 | β |
| Conceptualization of population-specific human functional immune-genomics projects to identify factors that contribute to variability in immune and infectious diseases. | Boahen CK et al. | β | 2021 | β |
| Dangerous liaisons: human genetic adaptation to infectious agents. | Quintana-Murci L | β | 2021 | β |
| Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes. | Ward MC et al. | β | 2021 | β |
| Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions. | Findley AS et al. | β | 2021 | β |
| Gene expression pattern analysis using dual-color RT-MLPA and integrative genome-wide association studies of eQTL for tuberculosis suscepitibility. | Ai JW et al. | β | 2021 | β |
| Genetic diversity of Japanese quail cathelicidins. | Ishige T et al. | β | 2021 | β |
| Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus. | Soliai MM et al. | β | 2021 | β |
| Psychosocial experiences modulate asthma-associated genes through gene-environment interactions. | Resztak JA et al. | β | 2021 | β |
| Tim-3 Relieves Experimental Autoimmune Encephalomyelitis by Suppressing MHC-II. | Tang L et al. | β | 2021 | β |
| Where Are the Disease-Associated eQTLs? | Umans BD et al. | β | 2021 | β |
| A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy. | Imran S et al. | β | 2020 | β |
| A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits. | Dahl A et al. | β | 2020 | β |
| Challenges of Immune Response Diversity in the Human Population Concerning New Tuberculosis Diagnostics, Therapies, and Vaccines. | Azad AK et al. | β | 2020 | β |
| Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension. | Ulrich A et al. | β | 2020 | β |
| Genetic Architecture of Gene Expression in European and African Americans: An eQTL Mapping Study in GENOA. | Shang L et al. | β | 2020 | β |
| Genetic Influences on Disease Subtypes. | Dahl A et al. | β | 2020 | β |
| Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines. | Theusch E et al. | β | 2020 | β |
| Genotype by environment interaction for gene expression in Drosophila melanogaster. | Huang W et al. | β | 2020 | β |
| Modeling of variables in cellularΒ infection reveals CXCL10 levels are regulated by human genetic variation and the Chlamydia-encoded CPAF protease. | Schott BH et al. | β | 2020 | β |
| Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults. | Hillary RF et al. | β | 2020 | β |
| Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk. | Huang QQ et al. | β | 2020 | β |
| The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection. | Giraud-Gatineau A et al. | β | 2020 | β |
| Ξ²-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1. | Moorlag SJCFM et al. | β | 2020 | β |
| A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees. | Ward MC et al. | β | 2019 | β |
| Characterising the genetic basis of immune response variation to identify causal mechanisms underlying disease susceptibility. | Rotival M | β | 2019 | β |
| Dual-Specificity Phosphatases in Immunity and Infection: An Update. | Lang R et al. | β | 2019 | β |
| Genetic analyses of human fetal retinal pigment epithelium gene expression suggest ocular disease mechanisms. | Liu B et al. | β | 2019 | β |
| Human Immunology through the Lens of Evolutionary Genetics. | Quintana-Murci L | β | 2019 | β |
| Immune stability predicts tuberculosis infection risk in a wild mammal. | Seguel M et al. | β | 2019 | β |
| Impact of the Polymorphism of the <i>PACRG</i> and <i>CD80</i> Genes on the Development of the Different Stages of Tuberculosis Infection. | Bragina EY et al. | β | 2019 | β |
| Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists. | Harrison GF et al. | β | 2019 | β |
| Single Nucleotide Polymorphisms at a Distance from Aryl Hydrocarbon Receptor (AHR) Binding Sites Influence AHR Ligand-Dependent Gene Expression. | Neavin DR et al. | β | 2019 | β |
| Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques. | Snyder-Mackler N et al. | β | 2019 | β |
| AmpliSeq transcriptome analysis of human alveolar and monocyte-derived macrophages over time in response to Mycobacterium tuberculosis infection. | Papp AC et al. | β | 2018 | β |
| Comparative Study of the Molecular Basis of Pathogenicity of <i>M. bovis</i> Strains in a Mouse Model. | Cheng G et al. | β | 2018 | β |
| Discovering in vivo cytokine-eQTL interactions from a lupus clinical trial. | Davenport EE et al. | β | 2018 | β |
| Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges. | Piasecka B et al. | β | 2018 | β |
| Dyslexia risk variant rs600753 is linked with dyslexia-specific differential allelic expression of DYX1C1. | MΓΌller B et al. | β | 2018 | β |
| Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation. | Husquin LT et al. | β | 2018 | β |
| Functional Genomics of Host-Microbiome Interactions in Humans. | Luca F et al. | β | 2018 | β |
| Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of <i>ERAP2</i> transcripts under balancing selection. | Ye CJ et al. | β | 2018 | β |
| Genetic and evolutionary determinants of human population variation in immune responses. | Sanz J et al. | β | 2018 | β |
| Genetic Resistance to <i>Mycobacterium tuberculosis</i> Infection and Disease. | MΓΆller M et al. | β | 2018 | β |
| Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives. | Abel L et al. | β | 2018 | β |
| Human genetics of mycobacterial disease. | Dallmann-Sauer M et al. | β | 2018 | β |
| Interactions between genetic variation and cellular environment in skeletal muscle gene expression. | Taylor DL et al. | β | 2018 | β |
| Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. | Fejzo MS et al. | β | 2018 | β |
| Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response. | Alasoo K et al. | β | 2018 | β |
| Vitamin D Regulation of the Uridine Phosphorylase 1 Gene and Uridine-Induced DNA Damage in Colon in African Americans and European Americans. | Bhasin N et al. | β | 2018 | β |
| Abundance and functional roles of intrinsic disorder in the antimicrobial peptides of the NK-lysin family. | Yacoub HA et al. | β | 2017 | β |
| Allele-specific expression reveals interactions between genetic variation and environment. | Knowles DA et al. | β | 2017 | β |
| Colonic transcriptional response to 1Ξ±,25(OH)<sub>2</sub> vitamin D<sub>3</sub> in African- and European-Americans. | Alleyne D et al. | β | 2017 | β |
| Context-specific effects of genetic variants associated with autoimmune disease. | Jonkers IH et al. | β | 2017 | β |
| Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases. | McAllister K et al. | β | 2017 | β |
| Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation. | Manry J et al. | β | 2017 | β |
| Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. | Ng MCY et al. | β | 2017 | β |
| Enhanced understanding of the host-pathogen interaction in sepsis: new opportunities for omic approaches. | Goh C et al. | β | 2017 | β |
| Evaluating the Impact of LTA4H Genotype and Immune Status on Survival From Tuberculous Meningitis. | Fava VM et al. | β | 2017 | β |
| Evidence of epigenetic admixture in the Colombian population. | Rawlik K et al. | β | 2017 | β |
| Genetic architecture of gene expression underlying variation in host response to porcine reproductive and respiratory syndrome virus infection. | Kommadath A et al. | β | 2017 | β |
| Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations. | Kim-Hellmuth S et al. | β | 2017 | β |
| Genomics of human pulmonary tuberculosis: from genes to pathways. | Stein CM et al. | β | 2017 | β |
| Human Genomics of <i>Mycobacterium tuberculosis</i> Infection and Disease. | Orlova M et al. | β | 2017 | β |
| Identification of context-dependent expression quantitative trait loci in whole blood. | Zhernakova DV et al. | β | 2017 | β |
| Incorporation of Biological Knowledge Into the Study of Gene-Environment Interactions. | Ritchie MD et al. | β | 2017 | β |
| Living in an adaptive world: Genomic dissection of the genus <i>Homo</i> and its immune response. | Quach H et al. | β | 2017 | β |
| Mapping eQTLs with RNA-seq reveals novel susceptibility genes, non-coding RNAs and alternative-splicing events in systemic lupus erythematosus. | Odhams CA et al. | β | 2017 | β |
| Pathogen lineage-based genome-wide association study identified CD53 as susceptible locus in tuberculosis. | Omae Y et al. | β | 2017 | β |
| Population Genetics and Natural Selection in Rheumatic Disease. | Ramos PS | β | 2017 | β |
| Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells. | Blischak JD et al. | β | 2017 | β |
| Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease. | Moreno-Moral A et al. | β | 2017 | β |
| The role of human host genetics in tuberculosis resistance. | Kinnear C et al. | β | 2017 | β |
| A genome-wide association study of pulmonary tuberculosis in Morocco. | Grant AV et al. | β | 2016 | β |
| Asthma Genetics in the Post-GWAS Era. | Ober C | β | 2016 | β |
| Autoimmune diseases - connecting risk alleles with molecular traits of the immune system. | Gutierrez-Arcelus M et al. | β | 2016 | β |
| Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23. | McGovern A et al. | β | 2016 | β |
| Concerted Genetic Function in Blood Traits. | Kim-Hellmuth S et al. | β | 2016 | β |
| Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes. | Burrows CK et al. | β | 2016 | β |
| Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations. | Quach H et al. | β | 2016 | β |
| Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens. | NΓ©dΓ©lec Y et al. | β | 2016 | β |
| Genetic and transcriptional analysis of human host response to healthy gut microbiota. | Richards AL et al. | β | 2016 | β |
| High-throughput allele-specific expression across 250 environmental conditions. | Moyerbrailean GA et al. | β | 2016 | β |
| Influence of the polymorphism of the DUSP14 gene on the expression of immune-related genes and development of pulmonary tuberculosis. | Hijikata M et al. | β | 2016 | β |
| Local Adaptation of Sun-Exposure-Dependent Gene Expression Regulation in Human Skin. | Kita R et al. | β | 2016 | β |
| Major Loci on Chromosomes 8q and 3q Control Interferon Ξ³ Production Triggered by Bacillus Calmette-Guerin and 6-kDa Early Secretory Antigen Target, Respectively, in Various Populations. | Jabot-Hanin F et al. | β | 2016 | β |
| Synergy between Common Ξ³ Chain Family Cytokines and IL-18 Potentiates Innate and Adaptive Pathways of NK Cell Activation. | Nielsen CM et al. | β | 2016 | β |
| The Role of Host Genetics (and Genomics) in Tuberculosis. | Naranbhai V | β | 2016 | β |
| Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection. | Tzelepis F et al. | β | 2015 | β |
| bacterial infection drives the expression dynamics of microRNAs and their isomiRs. | Siddle KJ et al. | β | 2015 | β |
| Bacterial infection remodels the DNA methylation landscape of human dendritic cells. | Pacis A et al. | β | 2015 | β |
| Call for a California coccidioidomycosis consortium to face the top ten challenges posed by a recalcitrant regional disease. | Thompson GR et al. | β | 2015 | β |
| Computational and analytical challenges in single-cell transcriptomics. | Stegle O et al. | β | 2015 | β |
| Cross-population joint analysis of eQTLs: fine mapping and functional annotation. | Wen X et al. | β | 2015 | β |
| Expression quantitative trait locus analysis for translational medicine. | Gibson G et al. | β | 2015 | β |
| Genetics of autoimmune diseases: insights from population genetics. | Ramos PS et al. | β | 2015 | β |
| Genome-wide Analysis of Host-Plasmodium yoelii Interactions Reveals Regulators of the Type I Interferon Response. | Wu J et al. | β | 2015 | β |
| Genomic modulators of gene expression in human neutrophils. | Naranbhai V et al. | β | 2015 | β |
| Host genetic variation influences gene expression response to rhinovirus infection. | ΓalΔ±Εkan M et al. | β | 2015 | β |
| Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy. | Begun J et al. | β | 2015 | β |
| Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study. | Subbian S et al. | β | 2015 | β |
| Mycobacterial infection induces a specific human innate immune response. | Blischak JD et al. | β | 2015 | β |
| QuASAR: quantitative allele-specific analysis of reads. | Harvey CT et al. | β | 2015 | β |
| Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. | Curtis J et al. | β | 2015 | β |
| The genetic architecture of gene expression levels in wild baboons. | Tung J et al. | β | 2015 | β |
| The role of regulatory variation in complex traits and disease. | Albert FW et al. | β | 2015 | β |
| Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection. | Hassan MA et al. | β | 2015 | β |
| A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection. | Siddle KJ et al. | β | 2014 | β |
| Cancer: Directions for the drivers. | Gibson G | β | 2014 | β |
| Common genetic variants modulate pathogen-sensing responses in human dendritic cells. | Lee MN et al. | β | 2014 | β |
| Determining causality and consequence of expression quantitative trait loci. | Battle A et al. | β | 2014 | β |
| Dissecting dynamic genetic variation that controls temporal gene response in yeast. | Brodt A et al. | β | 2014 | β |
| From genome to function by studying eQTLs. | Westra HJ et al. | β | 2014 | β |
| Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. | Tragante V et al. | β | 2014 | β |
| Gene co-expression network analysis identifies porcine genes associated with variation in Salmonella shedding. | Kommadath A et al. | β | 2014 | β |
| Genes associated with SLE are targets of recent positive selection. | Ramos PS et al. | β | 2014 | β |
| Genetic architecture of ethanol-responsive transcriptome variation in Saccharomyces cerevisiae strains. | Lewis JA et al. | β | 2014 | β |
| Genetics of gene expression in immunity to infection. | Fairfax BP et al. | β | 2014 | β |
| Genomic architecture of sickle cell disease in West African children. | Quinlan J et al. | β | 2014 | β |
| Genomics of host-pathogen interactions. | Rausell A et al. | β | 2014 | β |
| Heterogeneity among septic shock patients in a set of immunoregulatory markers. | Janols H et al. | β | 2014 | β |
| Human genetics of tuberculosis: a long and winding road. | Abel L et al. | β | 2014 | β |
| Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits. | Hassan MA et al. | β | 2014 | β |
| Multivariate inference of pathway activity in host immunity and response to therapeutics. | Goel G et al. | β | 2014 | β |
| Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. | Perry JR et al. | β | 2014 | β |
| Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. | Postmus I et al. | β | 2014 | β |
| Polymorphisms in the interleukin 18 receptor 1 gene and tuberculosis susceptibility among Chinese. | Zhang J et al. | β | 2014 | β |
| The ground state of innate immune responsiveness is determined at the interface of genetic, epigenetic, and environmental influences. | Huang E et al. | β | 2014 | β |
| The Red Queen's long race: human adaptation to pathogen pressure. | Siddle KJ et al. | β | 2014 | β |
| Trans-ethnic meta-analysis of white blood cell phenotypes. | Keller MF et al. | β | 2014 | β |
| When genetics meets epigenetics: deciphering the mechanisms controlling inter-individual variation in immune responses to infection. | Pacis A et al. | β | 2014 | β |
| Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region. | Grant AV et al. | β | 2013 | β |
| Co-infection with Mycobacterium tuberculosis and human immunodeficiency virus: an overview and motivation for systems approaches. | Deffur A et al. | β | 2013 | β |
| Common risk alleles for inflammatory diseases are targets of recent positive selection. | Raj T et al. | β | 2013 | β |
| Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli. | Gat-Viks I et al. | β | 2013 | β |
| Expression quantitative trait locus mapping across water availability environments reveals contrasting associations with genomic features in Arabidopsis. | Lowry DB et al. | β | 2013 | β |
| From genetics of inflammatory bowel disease towards mechanistic insights. | Graham DB et al. | β | 2013 | β |
| Genetics of human gene expression. | Stranger BE et al. | β | 2013 | β |
| Global properties and functional complexity of human gene regulatory variation. | Gaffney DJ | β | 2013 | β |
| Insights into TREM2 biology by network analysis of human brain gene expression data. | Forabosco P et al. | β | 2013 | β |
| Integrative genomic analysis of the human immune response to influenza vaccination. | Franco LM et al. | β | 2013 | β |
| Molecular immunologic correlates of spontaneous latency in a rabbit model of pulmonary tuberculosis. | Subbian S et al. | β | 2013 | β |
| Social environment influences the relationship between genotype and gene expression in wild baboons. | Runcie DE et al. | β | 2013 | β |
| Effects of a single nucleotide polymorphism in the chicken NK-lysin gene on antimicrobial activity and cytotoxicity of cancer cells. | Lee MO et al. | β | 2012 | β |
| Evidence for additive and interaction effects of host genotype and infection in malaria. | Idaghdour Y et al. | β | 2012 | β |
| Exploiting gene expression variation to capture gene-environment interactions for disease. | Idaghdour Y et al. | β | 2012 | β |
| Genetics. Gene losses in the human genome. | Quintana-Murci L | β | 2012 | β |
| Mapping gene-environment interactions at regulatory polymorphisms: insights into mechanisms of phenotypic variation. | Maranville JC et al. | β | 2012 | β |