Chunk #2 — METHODS — GWAS meta-analysis

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Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

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On meta-analysis, 3,915 SNPs reached the genome-wide significance threshold (P<5×10−8) for association with age at menarche (Figure 1). The overall GC inflation factor was 1.266, consistent with an expected high yield of true positive findings in large-scale GWAS meta-analysis of highly polygenic traits33.