The correlation between clinical laboratory data and telomeric status of male patients with metabolic disorders and no clinical history of vascular events.
- Authors
- Maeda, Toyoki; Oyama, Jun-ichi; Higuchi, Yoshihiro; Koyanagi, Masamichi; Sasaki, Makoto; Arima, Takahiro; Mimori, Koshi; Makino, Naoki
- Year
- 2011
- Journal
- The aging male : the official journal of the International Society for the Study of the Aging Male
- PMID
- 20670100
- DOI
- 10.3109/13685538.2010.502270
The telomere length and subtelomeric methylated status of peripheral blood leukocytes has been reported to be correlated with many kinds of pathophysiological conditions. However, the correlation between the telomeric parameters and clinical laboratory data in metabolic disorders is not well known. This study investigated the correlation between the telomere length and subtelomeric methylated status in peripheral leukocytes and the laboratory data of male outpatients with combined metabolic disorders and no clinical history of cardiovascular or cerebrovascular event were assessed, to find good clinical laboratory markers reflecting the biological aging. The laboratory data were collected in 26 Japanese male outpatients with diabetes mellitus and hyperlipidemia, and no history of cardiovascular or cerebrovascular event, and the telomeric parameters in their peripheral leukocytes were determined by Southern blot with methylation-sensitive and insensitive isoschizomers. Any correlations between the laboratory data and the telomeric parameters were assessed. The patients showed a significant negative correlation among the bilirubin and creatine phosphokinase with the aging-associate change of the telomeric and subtelomeric parameters. Lowered serum bilirubin and creatinine phosphokinase level correlated to genomic aging represented by telomere attrition of patients with metabolic disorders.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. | 2014 | 25231870 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Association between Combination Antiretroviral Therapy and Telomere Length in People Living with Human Immunodeficiency Virus. | Bukic E et al. | — | 2023 | → |
| Association of <i>FHL5</i> and <i>LPA</i> genetic polymorphisms with diabetes mellitus risk: a case-control study. | Xu X et al. | — | 2023 | → |
| Genomic circular DNA can behave to transpose another-locus-derived insert accompanied by autonomous rolling circle amplification | Maeda T | — | 2022 | — |
| Chromosomal terminal methylation status is associated with gut microbiotic alterations. | Maeda T et al. | — | 2021 | → |
| Shorter somatic telomere can be an increased risk for hospitalization. | Maeda T et al. | — | 2019 | → |
| Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. | Perry JR et al. | — | 2014 | → |
| Telomere length and type 2 diabetes in males, a premature aging syndrome. | Murillo-Ortiz B et al. | — | 2012 | → |