Subjects of European ancestry enrolled in the UW-TTURC trial with genotype and relapse data were included in this analysis (N=709, Table S1 for demographics). The CYP2A6 genotype-based metabolism function distribution in the UW-TTURC sample was: fast metabolizers (70.7%) and slow metabolizers (29.3%). In this treatment-seeking sample, fast nicotine metabolism was associated with more cigarettes smoked per day (CPD) at baseline, adjusted for age and gender (β=0.19, df=1, p=0.0024).
