The Collaborative Study on the Genetics of Alcoholism (COGA) sample (Begleiter and Reich, 1995) was recruited from treatment programs around six research sites in the United States, with probands and their extended families undergoing structured clinical interviews about alcohol use behaviors at the initial assessment and in multiple waves of follow up assessments. A subset of 118 families of European ancestry was selected for genotyping, as described by Wang et al. (2013). The maximum number of AUD symptoms across waves/ages was used for analysis, and this data was available for 2097 individuals (53.6% female), with a mean age at maximum AUD symptoms of 35.1 (range: 13-88). For more direct comparison with the younger population-based samples, we also replicate some analyses (see Data Analysis section below) in a subset of 879 young adults from the COGA families (M age = 20.9, range: 15-26).
