The data in Fig. 1a illustrate that there was no significant correlation between ethanol withdrawal and consumption in individual G19 HS4 mice (r=−0.02, p>0.68). The metrics being compared are grams per kilogram of ethanol consumed per 24 h and the CAUC for HIC scores (see “Materials and methods” for details on the calculation of the CAUC). The data in Fig. 1b illustrate that when the data are grouped according to family, there is a trend toward a negative correlation (r=−0.24, p>0.09). Among individual animals, males compared to females showed a significantly greater withdrawal score (6.25±0.43 vs 4.28±0.30—relative CAUC units, p<0.0003). In contrast, females as compared to males showed significantly greater ethanol consumption (2.84±0.29 vs 1.55±0.16 g/kg/24 h, p<0.0002). These data suggested that it would be of value to analyze the family data separately for males and females; the correlation between withdrawal and consumption was essentially unchanged (−0.16Males and −0.26Females).
