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Chunk #14 — Results — Ethanol withdrawal and consumption in G19 HS4 mice

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Detection of reciprocal quantitative trait loci for acute ethanol withdrawal and ethanol consumption in heterogeneous stock mice.
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Animals were identified on the basis of six different coat colors—black (86), brown (22), dilute (27), albino (80), agouti (78), and piebald (30). The ANOVA revealed no significant effect for coat color on ethanol withdrawal (p>0.8). There was a modestly significant coat color effect for consumption (F5,318=2.5, p<0.03); however, the post hoc analysis (Tukey HSD for unequal N) revealed no significant difference among groups. The trend was for higher ethanol consumption in the dilute animals. There was no significant family effect for consumption (p>0.60); however, the family effect for withdrawal was significant (F47,274=1.66, p<0.006). The range of family variation is illustrated in Fig. 1b.