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Chunk #43 — Discussion

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Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.
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0.06, p = 2.0×10−4), though a relatively large epidemiological study finds no association in affected individuals (Vogel et al. 2017). The negative correlation between anorexia nervosa and CRP (rg = −0.30 ± 0.08, p = 1.0×10-4) is borne out in a recent meta-analysis of relevant studies (Solmi et al. 2015). Another negative correlation between OCD and type 1 diabetes (rg = −0.32 ± 0.11, p = 5.4×10−3) finds no support within a limited body of literature (Sivertsen et al. 2014). However, the positive correlation between Tourette syndrome and allergy (rg = 0.24 ± 0.06, p = 2.7×10−5) is consistent with evidence of increased comorbidity between these phenotypes (Yuce et al. 2014; Chang et al. 2011). There is a paucity of clinical studies directly assessing the relationship between SZ and PBC (rg = 0.14 ± 0.05, p = 2.0 × 10−3). On the other hand, the correlation between SZ and SLE (rg = 0.15 ± 0.04, p = 2.0×10−4) appears to be supported by both epidemiological evidence of increased comorbidity (Tiosano et al. 2016) and the well-documented (although rare) phenomenon of CNS lupus presenting with SZ-like symptoms (Pego-Reigosa & Isenberg 2008), which may contribute to misdiagnosis. Finally, positive correlations involving cigarette