be supported by both epidemiological evidence of increased comorbidity (Tiosano et al. 2016) and the well-documented (although rare) phenomenon of CNS lupus presenting with SZ-like symptoms (Pego-Reigosa & Isenberg 2008), which may contribute to misdiagnosis. Finally, positive correlations involving cigarette smoking behavior and CRP (rg = 0.31 ± 0.07, p = 3.6×10−5), as well as rheumatoid arthritis (rg = 0.17 ± 0.05, p = 2.3×10−3), are perhaps unsurprising given considerable evidence of elevated CRP in persons who smoke (Ohsawa et al. 2005), and increased incidence of smoking behavior among individuals diagnosed with rheumatoid arthritis (Di Giuseppe et al. 2014). These findings may indicate a need for more adequate statistical treatment of smoking behavior in GWAS studies.
