location, object recognition and contextual fear. Consistent with this, hippocampal slices from BAF53ΔHD-expressing animals exhibit short-term potentiation (STP) but are unable to consolidate LTP. RNA-seq analysis of the dorsal hippocampus reveals that BAF53b+/− mice misregulate a variety of genes following object location memory training as compared to wild-type, including genes involved in transcriptional regulation, neurogenesis and chromatin modification, as well as those involved in cytoskeletal rearrangements and postsynaptic density. The role of nBAF in the adult CNS may be the basis for the pathogenicity of BAF subunit mutations in psychiatric disorders (Loe-Mie et al., 2010; Koga et al., 2009; Neale et al., 2012; O’Roak et al., 2012; Nord et al., 2011).
