The role of BAF (mSWI/SNF) complexes in mammalian neural development.

paper Cited Public

Authors: Son, Esther Y; Crabtree, Gerald R
Year: 2014
Journal: American journal of medical genetics. Part C, Seminars in medical genetics
PMID: 25195934
DOI: 10.1002/ajmg.c.31416
PMCID: PMC4405377

#	Section	Preview
0	INTRODUCTION	Putting together a stable yet versatile network such as the mammalian central nervous system poses a…
1	INTRODUCTION	How is our genetic information utilized to achieve this feat? In part, it involves the hierarchical…
2	INTRODUCTION	Three main epigenetic mechanisms cooperate to regulate the state of the chromatin (Bernstein et al.,…
3	INTRODUCTION	We begin by describing the emergence of mammalian BAF complexes, then look at specific BAF…
4	Evolution from the yeast SWI/SNF complex to mammalian BAF complexes [caps]	The subunits of the yeast SWI/SNF complex were first discovered in genetic screens for their…
5	Evolution from the yeast SWI/SNF complex to mammalian BAF complexes [caps]	In human, the DEAD/H helicase family of 29 genes codes for homologs of the yeast SWI2/SNF2, and are…
6	Evolution from the yeast SWI/SNF complex to mammalian BAF complexes [caps]	The 2-megadalton mammalian BAF complexes consist of at least 15 subunits, five of which have…
7	Evolution from the yeast SWI/SNF complex to mammalian BAF complexes [caps]	Another distinct feature of BAF complexes is the existence of alternative subunits for many of the…
8	ES cell-specific BAF (esBAF) complexes (caps)	Embryonic stem (ES) cells are derived from the inner cell mass (ICM) of the pre-implantation embryo…
9	ES cell-specific BAF (esBAF) complexes (caps) — esBAF in stem cell self-renewal and pluripotency	The peri-implantation lethal phenotype of mice lacking Brg1, BAF155 or BAF47 indicates that esBAF…
10	ES cell-specific BAF (esBAF) complexes (caps) — esBAF in stem cell self-renewal and pluripotency	The specific configuration of subunits in esBAF is crucial for the ES cell state. Brm, the…
11	ES cell-specific BAF (esBAF) complexes (caps) — esBAF, LIF/STAT3 signaling and opposition of Polycomb	Murine ES cells require leukemia inhibitory factor (LIF) signaling, which leads to phosphorylation…
12	ES cell-specific BAF (esBAF) complexes (caps) — esBAF, LIF/STAT3 signaling and opposition of Polycomb	One histone modification which is significantly altered in Brg1-knockout ES cells is histone H3…
13	ES cell-specific BAF (esBAF) complexes (caps) — esBAF, LIF/STAT3 signaling and opposition of Polycomb	This antagonistic relationship is conserved in flies, where homeotic transformations caused by PcG…
14	Neural progenitor BAF (npBAF) complexes	The development of the brain follows a stereotyped pattern beginning with the expansion of…
15	Neural progenitor BAF (npBAF) complexes	(Götz and Huttner, 2005; Kriegstein et al., 2006). Initially, RGs generate neurons directly…
16	Neural progenitor BAF (npBAF) complexes	Since the number of precursors and their mode of division critically influence final cortical size…
17	Neural progenitor BAF (npBAF) complexes — npBAF in neural progenitor self-renewal	Similar to the role of esBAF in ES cells, components of the nBAF complex have a critical role in the…
18	Neural progenitor BAF (npBAF) complexes — npBAF in neural progenitor self-renewal	astrocytes is reduced in the Nestin::Brg1−/− animals, the astrocytes themselves are not impaired…
19	Neural progenitor BAF (npBAF) complexes — npBAF in neural progenitor self-renewal	As would be expected, genetic perturbations of the three npBAF-specific subunits, BAF53a, BAF45a/d…

Name	Type
abnormal expansion of IPs local	phenotype
Abnormal spine morphology local	phenotype
Absence of cerebellum local	phenotype
ACTB	gene
ACTL6A local	gene
ACTL6B local	gene
ACTL6B+/- mice local	cohort
Agenesis of corpus callosum local	phenotype
ALS	phenotype
amyotrophic lateral sclerosis	phenotype
Anterior olfactory bulb local	anatomy
Apical VSNs local	phenotype
ARID1a local	gene
ARID1A local	gene
ARID1b local	gene
ARID1B local	gene
ASD	phenotype
astrocytes	phenotype
Asymmetric division of NSCs local	phenotype
ATP	drug
ATP-dependent chromatin remodeling local	drug
autism	phenotype
autism spectrum disorder	phenotype
axonal outgrowth local	phenotype
axonal pruning local	phenotype
axonogenesis	phenotype
axon pathfinding disruption local	phenotype
BAF	drug
BAF local	gene
BAF155 local	gene
BAF155 heterozygous mice local	cohort
BAF170 local	gene
BAF250 local	gene
BAF250a local	gene
BAF250b local	gene
BAF250B local	gene
BAF45a local	gene
BAF45b local	gene
BAF45c local	gene
BAF45d local	gene
BAF47 local	gene
BAF53 local	gene
BAF53a local	gene
BAF53A local	gene
BAF53b local	gene
BAF53B local	gene
BAF53b+/− mice local	cohort
BAF53b−/− mice local	cohort
BAF53ΔHD local	variant
BAF53ΔHD-expressing mice local	cohort
BAF57 local	gene
BAF60 local	gene
BAF60a local	gene
BAF60b local	gene
BAF60c local	gene
BAF complexes local	drug
BAF components local	drug
BAP55 local	gene
Basal VSNs local	phenotype
Bcl11b	gene
bias toward upper-layer identities local	phenotype
Brahma local	gene
brain	anatomy
brain development	phenotype
brainstem	anatomy
BRD7 local	gene
BRD9 local	gene
BrdU	drug
BRG1	gene
Brg1 heterozygous knockout mice local	cohort
Brg1 heterozygous mice local	cohort
BRG1 in-frame deletion local	variant
BRG1 missense mutation local	variant
Brm−/− mice local	cohort
BRM−/− mice local	cohort
Ca2+	drug
CALB1	gene
CAMK2A	gene
CBP local	drug
CBP	gene
CDKN2A	gene
cell cycle	phenotype
cell fate local	phenotype
central nervous system	anatomy
cerebellum	anatomy
CHD1 local	gene
CHD2 local	gene
CHD3 local	gene
CHD4 local	gene
CHD5 local	gene
CHD6 local	gene
CHD7 local	gene
CHD8	gene
CHD9	gene
chimeric BAF53a local	gene
chromatin	drug
chromatin modification local	phenotype
CNS	anatomy
CNTN4	gene
Coarse facial features local	phenotype
Coffin-Siris syndrome local	phenotype
cognitive disorders	phenotype
colon carcinoma local	phenotype
contextual fear local	phenotype
Contextual fear memory local	phenotype
Copy-number variations local	variant
CoREST	gene
corpus callosum	anatomy
cortex	anatomy
cortical layer II/III local	anatomy
cortical layer IV local	anatomy
cortical layer V	anatomy
cortical layer VI	anatomy
cortical progenitors local	anatomy
corticospinal neurons local	anatomy
corticothalamic neurons local	anatomy
CREB1	gene
CREST local	gene
CSS patients local	cohort
CTNNB1	gene
cytoskeletal rearrangements local	phenotype
Decreased proliferation local	phenotype
Decrease in BrdU+ progenitors local	phenotype
deep-layer cortical neurons local	anatomy
dendritic defects local	phenotype
dendritic outgrowth deficit local	phenotype
Dendritic outgrowth phenotype local	phenotype
dendritic remodeling local	phenotype
dendritogenesis local	phenotype
dentate gyrus	anatomy
depletion of upper-layer neurons local	phenotype
developmental delay	phenotype
digit malformations	phenotype
DNA	drug
DNA methylation	drug
DNase I	drug
dorsal cortex local	anatomy
dorsal hippocampus	anatomy
dorsal telencephalic fate local	phenotype
dorsal telencephalon local	anatomy
dorsal ventricular zone local	anatomy
DPF2 local	gene
DPF3 local	gene
Dyrk1A	gene
E2F transcription factors local	gene
embryonic lethality	phenotype
embryonic neural progenitor division local	phenotype
embryonic spinal cord local	anatomy
Emx1	gene
Enlarged interphalangeal joints local	phenotype
Ependymal lineage local	phenotype
Ephexin1 local	gene
epilepsy	phenotype
esBAF local	drug
Exome sequencing studies local	cohort
extra neuroblasts local	phenotype
EZH2	gene
fasciculation local	phenotype
Fifth fingernail hypoplasia local	phenotype
Forebrain excitatory neurons local	anatomy
GABA	phenotype
general population	cohort
generation of upper-layer cortical neurons local	phenotype
GFAP	gene
Glial lineage local	phenotype
glutamate	drug
Granule cell layer local	anatomy
greater disease severity local	phenotype
Growth delay local	phenotype
H3K27me3	drug
ham-3 local	gene
Hedgehog signaling pathway local	drug
hippocampal neurons	anatomy
hippocampus	anatomy
histone octamer local	drug
Histone tail covalent modifications local	drug
homeotic transformations local	phenotype
Hox	gene
human brain	anatomy
human malignancies local	phenotype
Human malignancy local	phenotype
hyperactivity	phenotype
Hypoplasia of fifth fingernails local	phenotype
idiopathic intellectual disability local	phenotype
impaired self-renewal local	phenotype
Increased cell death local	phenotype
increased cycling progenitors local	phenotype
indirect neurogenesis local	phenotype
induced neurons	phenotype
Inefficient teratoma formation local	phenotype
INO80 local	gene
intellectual disability	phenotype
intermediate progenitors	anatomy
IPs local	phenotype
KCl	drug
Ki67	drug
Large-scale studies local	cohort
lateral ventricle	anatomy
LIF	drug
long-term memory	phenotype
long-term potentiation	phenotype
Loss of OCT4 local	phenotype
loss of pluripotency local	phenotype
LTP	phenotype
macrocephaly	phenotype
malignant rhabdoid tumor local	phenotype
mating type switching local	phenotype
maturation local	phenotype
medium spiny neurons	anatomy
microcephaly	phenotype
midbrain	anatomy
miR-124	drug
miR-9* local	drug
miR-9* local	gene
Moira local	gene
mSin3A local	gene
mSWI/SNF local	drug
Multiple organ abnormalities local	phenotype
MULTIPOTENT PROGENITORS local	phenotype
Nanog	gene
nBAF local	drug
nBAF complex local	drug
nBAF complexes local	drug
nBAF-specific subunits local	drug
NCBRS patient cohort local	cohort
neocortex	anatomy
nestin	gene
NESTIN::BRG1−/− local	cohort
Nestin::Brg1−/− mice local	cohort
neural differentiation program local	phenotype
neural progenitor cell division local	phenotype
Neural progenitor pool depletion local	phenotype
Neural tube closure defect local	phenotype
Neural tube closure defects local	phenotype
NeuroD local	gene
NEUROD2	gene
neurodegenerative disease	phenotype
neurogenesis	phenotype
neurogenic miRNAs local	drug
neurological disorders	phenotype
neuronal differentiation	phenotype
neuronal fate	phenotype
neuronal lineage local	phenotype
Ngn2	gene
Nicolaides-Baraitser syndrome local	phenotype
Non-neuronal fate local	phenotype
Notch	gene
Notch signaling local	drug
npBAF local	drug
npBAF complex local	drug
NSC PROLIFERATION local	phenotype
object location memory	phenotype
Object recognition memory local	phenotype
Oct4	gene
odontogenesis local	phenotype
olfactory bulb	anatomy
olfactory projection neurons local	anatomy
Osa local	gene
outer RGs local	phenotype
outer SVZ local	anatomy
p.Arg366Cys local	variant
p.Asp1546Glu local	variant
pathfinding local	phenotype
patient cohort (Hoyer et al., 2012) local	cohort
Pax6	gene
PAX6-null mice local	cohort
PBRM1	gene
PcG local	drug
PcG local	gene
peri-implantation lethal phenotype local	phenotype
Perinatal death local	phenotype
perinatal lethality	phenotype
p.Gln388* local	variant
PHF10 local	gene
p.Ile123Met local	variant
plasticity of the adult brain local	phenotype
p.Lys364del local	variant
PNS dendritic morphogenesis defects local	phenotype
Polycomb local	gene
Polycomb complex local	drug
Polycomb complexes local	drug
postmitotic zone local	phenotype
postsynaptic density local	phenotype
POU5F1	gene
PRC2	drug
prefrontal cortex	anatomy
progenitor population local	phenotype
proliferation defects local	phenotype
proliferative neural progenitors local	phenotype
proliferative zone local	phenotype
psa-1 local	gene
psa-4 local	gene
psychiatric disorders	phenotype
radial glia	anatomy
reduced BrdU incorporation local	phenotype
Reduced Calb1 expression local	phenotype
Reduced number of GFAP+ astrocytes local	phenotype
Reduced pluripotency local	phenotype
Reduced proliferation of neural progenitors local	phenotype
reduced proliferative neural progenitors local	phenotype
Reduction in size and cell number of dentate gyrus local	phenotype
refinement of axons and dendrites local	phenotype
Rest	gene
retargeting phenotype local	phenotype
retinoic acid	drug
Retinoic acid receptor (RAR) local	gene
rhabdoid tumor local	phenotype
schizophrenia	phenotype
self-renewal impairment local	phenotype
serotonergic neurons	anatomy
SEZ local	anatomy
Shh	gene
Shorter dendrites local	phenotype
short-term memory	phenotype
short-term potentiation	phenotype
Slightly larger than normal local	phenotype
SMARCA1	gene
SMARCA2	gene
SMARCA5	gene
SMARCA6 local	gene
SMARCB1 local	gene
SMARCC1 local	gene
SMARCC2 local	gene
SMARCE1 local	gene
SNF5 local	gene
SNF6 local	gene
SNR1 local	gene
SOX11	gene
SOX11 mutation local	variant
Sox2	gene
Sparse hair local	phenotype
spinal cord	anatomy
Sporadic ID patients local	cohort
sporadic intellectual disability local	phenotype
SRCAP local	gene
SS18 local	gene
SS18L1 local	gene
STAT3	gene
striatum	anatomy
Stunted growth local	phenotype
subcerebral projection neurons local	anatomy
Subependymal zone local	anatomy
Subgranular zone	anatomy
subventricular zone	anatomy
sucrose	drug
sucrose utilization local	phenotype
SUZ12 local	gene
SWI1/ADR6 local	gene
SWI2/SNF2 local	gene
SWI3 local	gene
synaptic dysfunction	phenotype
synaptic plasticity	phenotype
synovial sarcoma local	phenotype
SZ	phenotype
T cell development local	phenotype
Thinning of cortex local	phenotype
Thinning of midbrain local	phenotype
thinning of upper cortical layers local	phenotype
trio sequencing study of sporadic ALS local	cohort
trithorax local	gene
Trithorax local	drug
TUBB3	gene
tumorigenesis	phenotype
upper cortical layers local	anatomy
upper-layer cortical neurons local	anatomy
V1r local	gene
V2r local	gene
ventral telencephalon	anatomy
ventricular RGs local	phenotype
ventricular zone	anatomy
Viable local	phenotype
voltage-sensitive Ca2+ channels local	drug
Vomeronasal sensory neurons local	phenotype
Weaver syndrome local	phenotype
β-actin	gene
β-catenin	drug
β-Tubulin-III local	drug
γ-aminobutyric acid	drug

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In this knowledge base

Title	Year	PMID
Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations.	2017	28981154

External

Title	Authors	Journal	Year	Link
Bilateral congenital glaucoma in a child with Nicolaides-Baraitser syndrome: a case report.	Alyahya YA et al.	—	2026	→
Developmental convergence and divergence in human stem cell models of autism.	Gordon A et al.	—	2026	→
ARID1A gene variants and fetal hydrocephalus: First evidence of mRNA decay escape.	Tanaka Y et al.	—	2025	→
Cell type-specific functions of the PBAF chromatin-remodeling complex in neuronal diversification.	Osuma A et al.	—	2025	→
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Synaptic activity causes minute-scale changes in BAF complex composition and function.	Gourisankar S et al.	—	2025	→
Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation.	Nazim M et al.	—	2024	→
A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus.	Singh AK et al.	—	2024	→
ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum.	Martins-Costa C et al.	—	2024	→
BAF45D-binding to HOX genes was differentially targeted in H9-derived spinal cord neural stem cells.	Liu C et al.	—	2024	→
Collaboration between distinct SWI/SNF chromatin remodeling complexes directs enhancer selection and activation of macrophage inflammatory genes.	Liao J et al.	—	2024	→
Context-specific functions of chromatin remodellers in development and disease.	Gourisankar S et al.	—	2024	→
Development and epigenetic regulation of Atypical teratoid/rhabdoid tumors in the context of cell-of-origin and halted cell differentiation.	Huhtala L et al.	—	2024	→
Epigenetic modulators provide a path to understanding disease and therapeutic opportunity.	Honer MA et al.	—	2024	→
Identification of novel BCL11A variant in a patient with developmental delay and behavioural differences.	Zha J et al.	—	2024	→
Mitochondrial complex I inhibition enhances astrocyte responsiveness to pro-inflammatory stimuli.	Wischhof L et al.	—	2024	→
Prenatal Coffin-Siris Syndrome: Expanding the Phenotypic and Genotypic Spectrum of the Disease.	Keskinen S et al.	—	2024	→
Abnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus.	Liu PP et al.	—	2023	→
Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism.	D'Incal CP et al.	—	2023	→
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation.	Păun O et al.	—	2023	→
Role of brahma-related gene 1/brahma-associated factor subunits in neural stem/progenitor cells and related neural developmental disorders.	Ke NY et al.	—	2023	→
SMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumors.	Liu NQ et al.	—	2023	→
The BAF chromatin remodeling complex licenses planarian stem cells access to ectodermal and mesodermal cell fates.	Wiggans M et al.	—	2023	→
Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides-Baraitser syndrome.	Shinko Y et al.	—	2022	→
Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons.	Liu PP et al.	—	2022	→
BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation.	Wischhof L et al.	—	2022	→
Conserved exchange of paralog proteins during neuronal differentiation.	Di Fraia D et al.	—	2022	→
FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A.	Wang X et al.	—	2022	→
Impact of SARS-CoV-2 on Host Factors Involved in Mental Disorders.	Rhoades R et al.	—	2022	→
Insights Into the Emerging Role of Baf53b in Autism Spectrum Disorder.	Rowland ME et al.	—	2022	→
Neurobiology of ARID1B haploinsufficiency related to neurodevelopmental and psychiatric disorders.	Moffat JJ et al.	—	2022	→
Ten-year follow-up of Nicolaides-Baraitser syndrome with a de novo mutation and analysis of 58 gene loci of SMARCA2-associated NCBRS.	Zhang X et al.	—	2022	→
The Essential Role of Epigenetic Modifications in Neurodegenerative Diseases with Dyskinesia.	Qi Z et al.	—	2022	→
The SWI/SNF chromatin remodeling assemblies BAF and PBAF differentially regulate cell cycle exit and cellular invasion in vivo.	Smith JJ et al.	—	2022	→
Transcription factors Bcl11a and Bcl11b are required for the production and differentiation of cortical projection neurons.	Du H et al.	—	2022	→
ACTL6A knockdown inhibits cell migration by suppressing the AKT signaling pathway and enhances the sensitivity of glioma cells to temozolomide.	Chen X et al.	—	2021	→
Arid1a regulates neural stem/progenitor cell proliferation and differentiation during cortical development.	Liu X et al.	—	2021	→
BAF45b Is Required for Efficient Zika Virus Infection of HAP1 Cells.	Persson BD et al.	—	2021	→
BAF Complex in Embryonic Stem Cells and Early Embryonic Development.	Zhang H et al.	—	2021	→
Brahma-related gene 1 has time-specific roles during brain and eye development.	Holdhof D et al.	—	2021	→
Chromatin remodeler <i>Arid1a</i> regulates subplate neuron identity and wiring of cortical connectivity.	Doyle DZ et al.	—	2021	→
Chromatin remodelling complexes in cerebral cortex development and neurodevelopmental disorders.	D'Souza L et al.	—	2021	→
COMPASS and SWI/SNF complexes in development and disease.	Cenik BK et al.	—	2021	→
Conserved exchange of paralog proteins during neuronal differentiation	Di Fraia D et al.	—	2021	—
Differential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex.	Moffat JJ et al.	—	2021	→
Loss of BAF Complex in Developing Cortex Perturbs Radial Neuronal Migration in a WNT Signaling-Dependent Manner.	Sokpor G et al.	—	2021	→
MSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells.	Hornbachner R et al.	—	2021	→
NELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growth.	Jayabal P et al.	—	2021	→
Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation.	Kim B et al.	—	2021	→
Nuclear isoform of FGF13 regulates post-natal neurogenesis in the hippocampus through an epigenomic mechanism.	Yang QQ et al.	—	2021	→
Potential Role of SWI/SNF Complex Subunit Actin-Like Protein 6A in Cervical Cancer.	Wang Q et al.	—	2021	→
Translational Diagnostics: An In-House Pipeline to Validate Genetic Variants in Children with Undiagnosed and Rare Diseases.	Pijuan J et al.	—	2021	→
ZMYND11 variants are a novel cause of centrotemporal and generalised epilepsies with neurodevelopmental disorder.	Oates S et al.	—	2021	→
Actin-like 6A enhances the proliferative and invasive capacities of laryngeal squamous cell carcinoma by potentiating the activation of YAP signaling.	Dang Y et al.	—	2020	→
An Activity-Mediated Transition in Transcription in Early Postnatal Neurons.	Stroud H et al.	—	2020	→
Bcl11 Transcription Factors Regulate Cortical Development and Function.	Simon R et al.	—	2020	→
Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptive redistribution of BAF complexes.	Wang Z et al.	—	2020	→
Histone Modifying Enzymes and Chromatin Modifiers in Glioma Pathobiology and Therapy Responses.	Ciechomska IA et al.	—	2020	→
Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism.	Wenderski W et al.	—	2020	→
Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies.	Centore RC et al.	—	2020	→
Structural Insights into the Evolutionarily Conserved BAF Chromatin Remodeling Complex.	Marcum RD et al.	—	2020	→
TP63 links chromatin remodeling and enhancer reprogramming to epidermal differentiation and squamous cell carcinoma development.	Yi M et al.	—	2020	→
Downregulation of DPF3 promotes the proliferation and motility of breast cancer cells through activating JAK2/STAT3 signaling.	Lin WH et al.	—	2019	→
Epigenetic cues modulating the generation of cell-type diversity in the cerebral cortex.	Amberg N et al.	—	2019	→
Epigenetic Regulations in Neuropsychiatric Disorders.	Kuehner JN et al.	—	2019	→
Expanding the Spectrum of BAF-Related Disorders: De Novo Variants in SMARCC2 Cause a Syndrome with Intellectual Disability and Developmental Delay.	Machol K et al.	—	2019	→
Genes and Mechanisms Involved in the Generation and Amplification of Basal Radial Glial Cells.	Penisson M et al.	—	2019	→
Individual components of the SWI/SNF chromatin remodelling complex have distinct roles in memory neurons of the <i>Drosophila</i> mushroom body.	Chubak MC et al.	—	2019	→
Intermediate progenitors and Tbr2 in cortical development.	Hevner RF	—	2019	→
Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons.	Bell S et al.	—	2019	→
Regulation of neuronal connectivity in the mammalian brain by chromatin remodeling.	Goodman JV et al.	—	2019	→
SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.	Ehrenhöfer-Wölfer K et al.	—	2019	→
The ARID1B spectrum in 143 patients: from nonsyndromic intellectual disability to Coffin-Siris syndrome.	van der Sluijs PJ et al.	—	2019	→
The BAF complex in development and disease.	Alfert A et al.	—	2019	→
The role of ARID1B, a BAF chromatin remodeling complex subunit, in neural development and behavior.	Moffat JJ et al.	—	2019	→
A brief overview of the Swi1 prion-[SWI+].	Goncharoff DK et al.	—	2018	→
Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers.	Hodges HC et al.	—	2018	→
Epigenetic regulation of neuroblastoma development.	Durinck K et al.	—	2018	→
Function of B-Cell CLL/Lymphoma 11B in Glial Progenitor Proliferation and Oligodendrocyte Maturation.	Wang CY et al.	—	2018	→
Nuclear receptor/Wnt beta-catenin interactions are regulated via differential CBP/p300 coactivator usage.	Ono M et al.	—	2018	→
smarce1 mutants have a defective endocardium and an increased expression of cardiac transcription factors in zebrafish.	Castillo-Robles J et al.	—	2018	→
The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	Elsen GE et al.	—	2018	→
The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling.	Knoll KR et al.	—	2018	→
A General Non-Radioactive ATPase Assay for Chromatin Remodeling Complexes.	Stanton BZ et al.	—	2017	→
Calcium signaling then and now, via Stockholm.	Bano D et al.	—	2017	→
Chromatin Remodeling BAF (SWI/SNF) Complexes in Neural Development and Disorders.	Sokpor G et al.	—	2017	→
Heterozygous variants in ACTL6A, encoding a component of the BAF complex, are associated with intellectual disability.	Marom R et al.	—	2017	→
Microduplication of the ARID1A gene causes intellectual disability with recognizable syndromic features.	Bidart M et al.	—	2017	→
Mining the topography and dynamics of the 4D Nucleome to identify novel CNS drug pathways.	Higgins GA et al.	—	2017	→
Network Reconstruction Reveals that Valproic Acid Activates Neurogenic Transcriptional Programs in Adult Brain Following Traumatic Injury.	Higgins GA et al.	—	2017	→
New SMARCA2 mutation in a patient with Nicolaides-Baraitser syndrome and myoclonic astatic epilepsy.	Tang S et al.	—	2017	→
Recruitment by the Repressor Freud-1 of Histone Deacetylase-Brg1 Chromatin Remodeling Complexes to Strengthen HTR1A Gene Repression.	Souslova T et al.	—	2017	→
RhoA Inhibitor Treatment At Acute Phase of Spinal Cord Injury May Induce Neurite Outgrowth and Synaptogenesis.	Devaux S et al.	—	2017	→
Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin.	Stanton BZ et al.	—	2017	→
The histone variant H3.3 claims its place in the crowded scene of epigenetics.	Bano D et al.	—	2017	→
The role of the SWI/SNF chromatin remodeling complex in maintaining the stemness of glioma initiating cells.	Hiramatsu H et al.	—	2017	→
The SWI/SNF subunit Bcl7a contributes to motor coordination and Purkinje cell function.	Wischhof L et al.	—	2017	→
Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations.	Mathies LD et al.	—	2017	→
A novel familial autosomal dominant mutation in ARID1B causing neurodevelopmental delays, short stature, and dysmorphic features.	Smith JA et al.	—	2016	→
Autism-Associated Chromatin Regulator Brg1/SmarcA4 Is Required for Synapse Development and Myocyte Enhancer Factor 2-Mediated Synapse Remodeling.	Zhang Z et al.	—	2016	→
BCL11A Haploinsufficiency Causes an Intellectual Disability Syndrome and Dysregulates Transcription.	Dias C et al.	—	2016	→
Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish.	Xiao C et al.	—	2016	→
Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.	Sutherell CL et al.	—	2016	→
Polycomb and trithorax opposition in development and disease.	Poynter ST et al.	—	2016	→
Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming.	Smith DK et al.	—	2016	→
The developmental and pathogenic roles of BAF57, a special subunit of the BAF chromatin-remodeling complex.	Lomelí H et al.	—	2016	→
Toward development of epigenetic drugs for central nervous system disorders: Modulating neuroplasticity via H3K4 methylation.	Ricq EL et al.	—	2016	→
Chromatin-Remodeling-Factor ARID1B Represses Wnt/β-Catenin Signaling.	Vasileiou G et al.	—	2015	→
Chromatin Remodeling Factor Brg1 Supports the Early Maintenance and Late Responsiveness of Nestin-Lineage Adult Neural Stem and Progenitor Cells.	Petrik D et al.	—	2015	→
Epigenetic changes in the developing brain: Effects on behavior.	Keverne EB et al.	—	2015	→
From trans to cis: transcriptional regulatory networks in neocortical development.	Shibata M et al.	—	2015	→
Functional Insights into Chromatin Remodelling from Studies on CHARGE Syndrome.	Basson MA et al.	—	2015	→
Mutations in ARID2 are associated with intellectual disabilities.	Shang L et al.	—	2015	→
Open access chemical probes for epigenetic targets.	Brown PJ et al.	—	2015	→
Coffin-Siris syndrome and related disorders involving components of the BAF (mSWI/SNF) complex: historical review and recent advances using next generation sequencing.	Kosho T et al.	—	2014	→