astrocytes is reduced in the Nestin::Brg1−/− animals, the astrocytes themselves are not impaired in their ability to divide, indicating that the effect on proliferation is specific to the multipotent progenitors. At the transcriptional level, Brg1-containing npBAF complexes activate Notch signaling pathway components to promote NSC proliferation, while repressing genes involved in Sonig Hedgehog (Shh) signaling which plays a vital role in neural patterning (Lessard et al., 2007; Rowitch et al., 1999; Chiang et al., 1996).
