In human, the DEAD/H helicase family of 29 genes codes for homologs of the yeast SWI2/SNF2, and are involved in a diverse range of functions that pertain to the chromatin including DNA replication and repair, transcriptional initiation and elongation, mRNA splicing and gene silencing (Hargreaves and Crabtree, 2011; Yoo and Crabtree, 2009). Several members also serve as core subunits in ATP-dependent chromatin remodeling complexes of which there are 4 families: BAF (which uses BRG1 or hBRM), INO80/SWR1 (which uses hINO80, hDomino or SRCAP), ISWI (which uses hSNF2H or hSNF2L) and CHD (which uses CHD1 through CHD9).
