A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.
paper
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- Authors
- Bultman, S; Gebuhr, T; Yee, D; La Mantia, C; Nicholson, J; Gilliam, A; Randazzo, F; Metzger, D; Chambon, P; Crabtree, G; Magnuson, T
- Year
- 2000
- Journal
- Molecular cell
- PMID
- 11163203
- DOI
- 10.1016/s1097-2765(00)00127-1
Mammalian SWI/SNF complexes utilize either brahma (Brm) or brahma-related gene 1 (Brg1) catalytic subunits to remodel nucleosomes in an ATP-dependent manner. Brm was previously shown to be dispensable, suggesting that Brm and Brg1 are functionally redundant. To test this hypothesis, we have generated a Brg1 null mutation by gene targeting, and, surprisingly, homozygotes die during the periimplantation stage. Furthermore, blastocyst outgrowth studies indicate that neither the inner cell mass nor trophectoderm survives. However, experiments with other cell types demonstrate that Brg1 is not a general cell survival factor. In addition, Brg1 heterozygotes are predisposed to exencephaly and tumors. These results provide evidence that biochemically similar chromatin-remodeling complexes have dramatically different functions during mammalian development.
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| Differential Expression of SWI/SNF Chromatin Remodeler Subunits Brahma and Brahma-Related Gene During Drug-Induced Liver Injury and Regeneration in Mouse Model. | Sinha S et al. | β | 2016 | β |
| Epigenetic Regulation by ATP-Dependent Chromatin-Remodeling Enzymes: SNF-ing Out Crosstalk. | Runge JS et al. | β | 2016 | β |
| Glucocorticoid receptor-mediated <i>cis</i>-repression of osteogenic genes requires BRM-SWI/SNF. | Pico MJ et al. | β | 2016 | β |
| Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit. | Gerstenberger BS et al. | β | 2016 | β |
| Ino80 is essential for proximal-distal axis asymmetry in part by regulating Bmp4 expression. | Qiu Z et al. | β | 2016 | β |
| LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. | Zhu P et al. | β | 2016 | β |
| Loss of the SWI/SNF ATPase subunits BRM and BRG1 drives lung cancer development. | Marquez-Vilendrer SB et al. | β | 2016 | β |
| Mechanism of BRG1 silencing in primary cancers. | Marquez-Vilendrer SB et al. | β | 2016 | β |
| Multifunctional adaptor protein Daxx interacts with chromatin-remodelling ATPase Brg1. | Svadlenka J et al. | β | 2016 | β |
| Overexpression of Telomerase Reverse Transcriptase Induces Autism-like Excitatory Phenotypes in Mice. | Kim KC et al. | β | 2016 | β |
| Polycomb and trithorax opposition in development and disease. | Poynter ST et al. | β | 2016 | β |
| PRC2 and SWI/SNF Chromatin Remodeling Complexes in Health and Disease. | Kadoch C et al. | β | 2016 | β |
| Signaling Control of Differentiation of Embryonic Stem Cells toward Mesendoderm. | Wang L et al. | β | 2016 | β |
| SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells. | Barutcu AR et al. | β | 2016 | β |
| SWI/SNF-directed stem cell lineage specification: dynamic composition regulates specific stages of skeletal myogenesis. | Toto PC et al. | β | 2016 | β |
| The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo. | Panamarova M et al. | β | 2016 | β |
| The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance. | Teichroeb JH et al. | β | 2016 | β |
| The SWI/SNF chromatin remodeling complex exerts both negative and positive control over LET-23/EGFR-dependent vulval induction in Caenorhabditis elegans. | Flibotte S et al. | β | 2016 | β |
| Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. | Cui W et al. | β | 2016 | β |
| A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy. | Weng X et al. | β | 2015 | β |
| Biallelic germline and somatic mutations in malignant mesothelioma: multiple mutations in transcription regulators including mSWI/SNF genes. | Yoshikawa Y et al. | β | 2015 | β |
| Biological Relevance and Therapeutic Potential of the Hypusine Modification System. | PΓ€llmann N et al. | β | 2015 | β |
| Brahma is required for cell cycle arrest and late muscle gene expression during skeletal myogenesis. | Albini S et al. | β | 2015 | β |
| Brahma regulates the Hippo pathway activity through forming complex with Yki-Sd and regulating the transcription of Crumbs. | Zhu Y et al. | β | 2015 | β |
| Brg1 Controls the Expression of Pax7 to Promote Viability and Proliferation of Mouse Primary Myoblasts. | Padilla-Benavides T et al. | β | 2015 | β |
| Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma. | Aldiri I et al. | β | 2015 | β |
| BRG1 Governs Nanog Transcription in Early Mouse Embryos and Embryonic Stem Cells via Antagonism of Histone H3 Lysine 9/14 Acetylation. | Carey TS et al. | β | 2015 | β |
| Brg1 modulates enhancer activation in mesoderm lineage commitment. | Alexander JM et al. | β | 2015 | β |
| BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51. | Qi W et al. | β | 2015 | β |
| Central nervous system-specific knockout of Brg1 causes growth retardation and neuronal degeneration. | Deng L et al. | β | 2015 | β |
| Chromatin Remodeling Factor Brg1 Supports the Early Maintenance and Late Responsiveness of Nestin-Lineage Adult Neural Stem and Progenitor Cells. | Petrik D et al. | β | 2015 | β |
| Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet Ξ² cells. | McKenna B et al. | β | 2015 | β |
| Endocardial Brg1 disruption illustrates the developmental origins of semilunar valve disease. | Akerberg BN et al. | β | 2015 | β |
| Establishing pluripotency in early development. | Paranjpe SS et al. | β | 2015 | β |
| Global genetic analysis in mice unveils central role for cilia in congenital heart disease. | Li Y et al. | β | 2015 | β |
| Induction of functional Brm protein from Brm knockout mice. | Thompson KW et al. | β | 2015 | β |
| Med14 cooperates with brg1 in the differentiation of skeletogenic neural crest. | Lou X et al. | β | 2015 | β |
| Non-targeted metabolomics of <i>Brg1/Brm</i> double-mutant cardiomyocytes reveals a novel role for SWI/SNF complexes in metabolic homeostasis. | Banerjee R et al. | β | 2015 | β |
| Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme. | Nasipak BT et al. | β | 2015 | β |
| Pontin functions as an essential coactivator for Oct4-dependent lincRNA expression in mouse embryonic stem cells. | Boo K et al. | β | 2015 | β |
| Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance. | Fedorov O et al. | β | 2015 | β |
| SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies transcriptionally related to BAF-deficient sarcomas. | Le Loarer F et al. | β | 2015 | β |
| SWI/SNF chromatin-remodeling enzymes Brahma-related gene 1 (BRG1) and Brahma (BRM) are dispensable in multiple models of postnatal angiogenesis but are required for vascular integrity in infant mice. | Wiley MM et al. | β | 2015 | β |
| SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans. | Mathies LD et al. | β | 2015 | β |
| SWI/SNF complexes are required for full activation of the DNA-damage response. | Smith-Roe SL et al. | β | 2015 | β |
| SWI/SNF-Mediated Lineage Determination in Mesenchymal Stem Cells Confers Resistance to Osteoporosis. | Nguyen KH et al. | β | 2015 | β |
| SWI/SNF Subunits SMARCA4, SMARCD2 and DPF2 Collaborate in MLL-Rearranged Leukaemia Maintenance. | Cruickshank VA et al. | β | 2015 | β |
| The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation. | Wu Q et al. | β | 2015 | β |
| Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System. | Emery B et al. | β | 2015 | β |
| Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells. | Laurette P et al. | β | 2015 | β |
| Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. | Singh AP et al. | β | 2014 | β |
| A rationale to target the SWI/SNF complex for cancer therapy. | Hohmann AF et al. | β | 2014 | β |
| ARID1B is a specific vulnerability in ARID1A-mutant cancers. | Helming KC et al. | β | 2014 | β |
| ATP-dependent chromatin remodeling complexes as novel targets for cancer therapy. | Mayes K et al. | β | 2014 | β |
| A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice. | Harmacek L et al. | β | 2014 | β |
| Beyond Mutations: Additional Mechanisms and Implications of SWI/SNF Complex Inactivation. | Marquez SB et al. | β | 2014 | β |
| BRG1 Is Required to Maintain Pluripotency of Murine Embryonic Stem Cells. | Singhal N et al. | β | 2014 | β |
| Caenorhabditis elegans SWI/SNF subunits control sequential developmental stages in the somatic gonad. | Large EE et al. | β | 2014 | β |
| Characterization of a Brg1Β hypomorphic allele demonstrates that genetic and biochemical activity are tightly correlated. | Chandler RL et al. | β | 2014 | β |
| Chromatin modifiers and remodellers: regulators of cellular differentiation. | Chen T et al. | β | 2014 | β |
| Chromatin remodeler mutations in human cancers: epigenetic implications. | Skulte KA et al. | β | 2014 | β |
| Chromatin remodeling: from transcription to cancer. | Yaniv M | β | 2014 | β |
| Driver mutations of cancer epigenomes. | Roy DM et al. | β | 2014 | β |
| Epigenetic control of cell fate in mouse blastocysts: the role of covalent histone modifications and chromatin remodeling. | Paul S et al. | β | 2014 | β |
| Epigenetics in cardiac development, function, and disease. | NΓΌhrenberg T et al. | β | 2014 | β |
| Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance. | Buscarlet M et al. | β | 2014 | β |
| Flightless I (Drosophila) homolog facilitates chromatin accessibility of the estrogen receptor Ξ± target genes in MCF-7 breast cancer cells. | Jeong KW | β | 2014 | β |
| Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers. | Hoffman GR et al. | β | 2014 | β |
| Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation. | Patterson ES et al. | β | 2014 | β |
| Genetic variant in SWI/SNF complexes influences hepatocellular carcinoma risk: a new clue for the contribution of chromatin remodeling in carcinogenesis. | Zhong R et al. | β | 2014 | β |
| Hyperlipidaemia impairs the circadian clock and physiological homeostasis of vascular smooth muscle cells via the suppression of Smarcd1. | Chen S et al. | β | 2014 | β |
| Identifying targets for the restoration and reactivation of BRM. | Kahali B et al. | β | 2014 | β |
| Loss of the tumor suppressor SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). | Ramos P et al. | β | 2014 | β |
| Mammalian cells contain two functionally distinct PBAF complexes incorporating different isoforms of PHF10 signature subunit. | Brechalov AV et al. | β | 2014 | β |
| Maternal effect genes: Findings and effects on mouse embryo development. | Kim KH et al. | β | 2014 | β |
| Neuron-specific chromatin remodeling: a missing link in epigenetic mechanisms underlying synaptic plasticity, memory, and intellectual disability disorders. | Vogel-Ciernia A et al. | β | 2014 | β |
| Novel mechanism of negative regulation of 1,25-dihydroxyvitamin D3-induced 25-hydroxyvitamin D3 24-hydroxylase (Cyp24a1) Transcription: epigenetic modification involving cross-talk between protein-arginine methyltransferase 5 and the SWI/SNF complex. | Seth-Vollenweider T et al. | β | 2014 | β |
| Overlapping chromatin-remodeling systems collaborate genome wide at dynamic chromatin transitions. | Morris SA et al. | β | 2014 | β |
| Phenotype and genotype in Nicolaides-Baraitser syndrome. | Sousa SB et al. | β | 2014 | β |
| Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation. | Wilson BG et al. | β | 2014 | β |
| SWI/SNF chromatin remodeling complexes and cancer. | Biegel JA et al. | β | 2014 | β |
| SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease. | Bevilacqua A et al. | β | 2014 | β |
| SWI/SNF chromatin remodeling enzymes in melanocyte differentiation and melanoma. | Mehrotra A et al. | β | 2014 | β |
| The role of BAF (mSWI/SNF) complexes in mammalian neural development. | Son EY et al. | β | 2014 | β |
| Tissue-specific SMARCA4 binding at active and repressed regulatory elements during embryogenesis. | Attanasio C et al. | β | 2014 | β |
| Transcriptional regulation by trithorax-group proteins. | Kingston RE et al. | β | 2014 | β |
| Transcriptional regulators of the trophoblast lineage in mammals with hemochorial placentation. | Knott JG et al. | β | 2014 | β |
| Whole genome expression profiling shows that BRG1 transcriptionally regulates UV inducible genes and other novel targets in human cells. | Zhang L et al. | β | 2014 | β |
| ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4. | Bao X et al. | β | 2013 | β |
| Alterations of the SWI/SNF chromatin remodelling subunit-BRG1 and BRM in hepatocellular carcinoma. | Endo M et al. | β | 2013 | β |
| An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. | Daxinger L et al. | β | 2013 | β |
| Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling. | Jin Y et al. | β | 2013 | β |
| Brahma-related gene 1 bridges epigenetic regulation of proinflammatory cytokine production to steatohepatitis in mice. | Tian W et al. | β | 2013 | β |
| Brg1-dependent epigenetic control of vascular smooth muscle cell proliferation by hydrogen sulfide. | Li L et al. | β | 2013 | β |
| Brg1 determines urothelial cell fate during ureter development. | Weiss RM et al. | β | 2013 | β |
| BRG1 is a prognostic marker and potential therapeutic target in human breast cancer. | Bai J et al. | β | 2013 | β |
| BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss. | Tu Z et al. | β | 2013 | β |
| Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner. | Holik AZ et al. | β | 2013 | β |
| Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development. | Smith-Roe SL et al. | β | 2013 | β |
| Connecting the dots from fatty acids to nonalcoholic steatohepatitis: epigenetics in the spotlight. | Selaru FM et al. | β | 2013 | β |
| Creating a neural specific chromatin landscape by npBAF and nBAF complexes. | Staahl BT et al. | β | 2013 | β |
| Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective. | Liang G et al. | β | 2013 | β |
| Epigenetic alterations in acute kidney injury. | Bomsztyk K et al. | β | 2013 | β |
| Epigenetic regulation of inducible gene expression in the immune system. | Lim PS et al. | β | 2013 | β |
| Epigenomic regulation of bile acid metabolism: emerging role of transcriptional cofactors. | Smith Z et al. | β | 2013 | β |
| Exome sequencing to identify de novo mutations in sporadic ALS trios. | Chesi A et al. | β | 2013 | β |
| From neural development to cognition: unexpected roles for chromatin. | Ronan JL et al. | β | 2013 | β |
| Functional interaction of SCAI with the SWI/SNF complex for transcription and tumor cell invasion. | KreΓner C et al. | β | 2013 | β |
| Histone regulation in the CNS: basic principles of epigenetic plasticity. | Maze I et al. | β | 2013 | β |
| Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways. | Staahl BT et al. | β | 2013 | β |
| miR-9*- and miR-124a-Mediated switching of chromatin remodelling complexes is altered in rat spina bifida aperta. | Wei X et al. | β | 2013 | β |
| Mouse models in epigenetics: insights in development and disease. | Espada J et al. | β | 2013 | β |
| NFAT gene family in inflammation and cancer. | Pan MG et al. | β | 2013 | β |
| Nuclear shape changes are induced by knockdown of the SWI/SNF ATPase BRG1 and are independent of cytoskeletal connections. | Imbalzano KM et al. | β | 2013 | β |
| PBRM1 and BAP1 as novel targets for renal cell carcinoma. | Brugarolas J | β | 2013 | β |
| Regulation of microRNAs by Brahma-related gene 1 (Brg1) in smooth muscle cells. | Chen M et al. | β | 2013 | β |
| SWI/SNF enzymes promote SOX10- mediated activation of myelin gene expression. | Marathe HG et al. | β | 2013 | β |
| The epigenomics of embryonic stem cell differentiation. | Kraushaar DC et al. | β | 2013 | β |
| The use of mouse models to study epigenetics. | Blewitt M et al. | β | 2013 | β |
| ATP-dependent chromatin remodeling in T cells. | Wurster AL et al. | β | 2012 | β |
| BAF60 A, B, and Cs of muscle determination and renewal. | Puri PL et al. | β | 2012 | β |
| BET domain co-regulators in obesity, inflammation and cancer. | Belkina AC et al. | β | 2012 | β |
| Cell fate regulation in early mammalian development. | Oron E et al. | β | 2012 | β |
| Chromatin as an oxygen sensor and active player in the hypoxia response. | Melvin A et al. | β | 2012 | β |
| Chromatin-remodeling complex specificity and embryonic vascular development. | Curtis CD et al. | β | 2012 | β |
| Chromatin remodeling during glucocorticoid receptor regulated transactivation. | King HA et al. | β | 2012 | β |
| Diverse functions of ATP-dependent chromatin remodeling complexes in development and cancer. | Wu JI | β | 2012 | β |
| Epigenetic landscape of pluripotent stem cells. | Han JW et al. | β | 2012 | β |
| Epigenetic regulation of cardiac development and function by polycomb group and trithorax group proteins. | Wang QT | β | 2012 | β |
| Essential role of ARID2 protein-containing SWI/SNF complex in tissue-specific gene expression. | Xu F et al. | β | 2012 | β |
| Essential roles of the chromatin remodeling factor BRG1 in spermatogenesis in mice. | Wang J et al. | β | 2012 | β |
| EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. | Ahmed M et al. | β | 2012 | β |
| Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart. | Willis MS et al. | β | 2012 | β |
| Genetic and epigenetic events generate multiple pathways in colorectal cancer progression. | Pancione M et al. | β | 2012 | β |
| Global epigenetic changes induced by SWI2/SNF2 inhibitors characterize neomycin-resistant mammalian cells. | Dutta P et al. | β | 2012 | β |
| Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome. | Van Houdt JK et al. | β | 2012 | β |
| Immunolocalization of BRG1-SWI/SNF protein during folliculogenesis in the porcine ovary. | Lisboa LA et al. | β | 2012 | β |
| Lessons from senescence: Chromatin maintenance in non-proliferating cells. | Rai TS et al. | β | 2012 | β |
| Loss of expression of the SWI/SNF chromatin remodeling subunit BRG1/SMARCA4 is frequently observed in intraductal papillary mucinous neoplasms of the pancreas. | Dal Molin M et al. | β | 2012 | β |
| Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome. | Tsurusaki Y et al. | β | 2012 | β |
| NuRD and pluripotency: a complex balancing act. | Hu G et al. | β | 2012 | β |
| Regulation of gene expression during early neuronal differentiation: evidence for patterns conserved across neuron populations and vertebrate classes. | Ernsberger U | β | 2012 | β |
| Regulation of transcription and chromatin structure by pRB: here, there and everywhere. | Talluri S et al. | β | 2012 | β |
| Serum starvation induces DRAM expression in liver cancer cells via histone modifications within its promoter locus. | Ni P et al. | β | 2012 | β |
| SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking CHFR mediated ubiquitination and degradation of its major components. | Jung I et al. | β | 2012 | β |
| SWI/SNF chromatin remodeling complex: a new cofactor in reprogramming. | He L et al. | β | 2012 | β |
| SWI/SNF complex in disorder: SWItching from malignancies to intellectual disability. | Santen GW et al. | β | 2012 | β |
| Targeting the epigenome for treatment of cancer. | Geutjes EJ et al. | β | 2012 | β |
| The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner. | Serber DW et al. | β | 2012 | β |
| The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. | Curtis CD et al. | β | 2012 | β |
| Tracking the mechanical dynamics of human embryonic stem cell chromatin. | Hinde E et al. | β | 2012 | β |
| ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. | Hargreaves DC et al. | β | 2011 | β |
| Biology of the Mi-2/NuRD Complex in SLAC (Stemness, Longevity/Ageing, and Cancer). | Zhang Y | β | 2011 | β |
| BRG1 mutations found in human cancer cell lines inactivate Rb-mediated cell-cycle arrest. | Bartlett C et al. | β | 2011 | β |
| BRM and BRG1 subunits of the SWI/SNF chromatin remodelling complex are downregulated upon progression of benign skin lesions into invasive tumours. | Bock VL et al. | β | 2011 | β |
| Chromatin regulation landscape of embryonic stem cell identity. | Lee YH et al. | β | 2011 | β |
| Chromatin remodeling in cardiovascular development and physiology. | Han P et al. | β | 2011 | β |
| Chromatin remodelling complex dosage modulates transcription factor function in heart development. | Takeuchi JK et al. | β | 2011 | β |
| Combinatorial assembly and function of chromatin regulatory complexes. | Lange M et al. | β | 2011 | β |
| esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function. | Ho L et al. | β | 2011 | β |
| Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene. | DelBove J et al. | β | 2011 | β |
| Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation. | Bottardi S et al. | β | 2011 | β |
| MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4. | Schramedei K et al. | β | 2011 | β |
| MicroRNAs miR-199a-5p and -3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers. | Sakurai K et al. | β | 2011 | β |
| NF-ΞΊB and BRG1 bind a distal regulatory element in the IL-3/GM-CSF locus. | Wurster AL et al. | β | 2011 | β |
| Open chromatin in pluripotency and reprogramming. | Gaspar-Maia A et al. | β | 2011 | β |
| Promyelocytic leukemia protein in retinoic acid-induced chromatin remodeling of Oct4 gene promoter. | Chuang YS et al. | β | 2011 | β |
| Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1. | Hu G et al. | β | 2011 | β |
| Repressor of estrogen receptor activity (REA) is essential for mammary gland morphogenesis and functional activities: studies in conditional knockout mice. | Park S et al. | β | 2011 | β |
| Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development. | Dawe CE et al. | β | 2011 | β |
| SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription. | Vizlin-Hodzic D et al. | β | 2011 | β |
| Srg3, a mouse homolog of BAF155, is a novel p53 target and acts as a tumor suppressor by modulating p21(WAF1/CIP1) expression. | Ahn J et al. | β | 2011 | β |
| SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development. | Zhang M et al. | β | 2011 | β |
| SWI/SNF nucleosome remodellers and cancer. | Wilson BG et al. | β | 2011 | β |
| SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster. | Waldholm J et al. | β | 2011 | β |
| Target genes of the largest human SWI/SNF complex subunit control cell growth. | Inoue H et al. | β | 2011 | β |
| The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels. | Griffin CT et al. | β | 2011 | β |
| The emerging role of epigenetic mechanisms in the etiology of neural tube defects. | Greene ND et al. | β | 2011 | β |
| Trithorax group proteins: switching genes on and keeping them active. | Schuettengruber B et al. | β | 2011 | β |
| What chick and mouse models have taught us about the role of the endocardium in congenital heart disease. | DeLaughter DM et al. | β | 2011 | β |
| Williams syndrome is an epigenome-regulator disease. | Kitagawa H et al. | β | 2011 | β |
| Wnt/Ξ²-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming. | Miki T et al. | β | 2011 | β |
| An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis. | Denis GV et al. | β | 2010 | β |
| A switch from hBrm to Brg1 at IFNΞ³-activated sequences mediates the activation of human genes. | Zhang Y et al. | β | 2010 | β |
| ATP dependent chromatin remodeling enzymes in embryonic stem cells. | Saladi SV et al. | β | 2010 | β |
| BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression. | Cohen SM et al. | β | 2010 | β |
| BRG1 expression is increased in human cutaneous melanoma. | Lin H et al. | β | 2010 | β |
| Brg1 is required for Cdx2-mediated repression of Oct4 expression in mouse blastocysts. | Wang K et al. | β | 2010 | β |
| Chromatin dynamics associated with HIV-1 Tat-activated transcription. | Easley R et al. | β | 2010 | β |
| Chromatin regulation by Brg1 underlies heart muscle development and disease. | Hang CT et al. | β | 2010 | β |
| Chromatin regulatory mechanisms in pluripotency. | Lessard JA et al. | β | 2010 | β |
| Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming. | Singhal N et al. | β | 2010 | β |
| Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. | He S et al. | β | 2010 | β |
| Chromatin remodeling in heart development. | Bruneau BG | β | 2010 | β |
| Chromatin remodelling during development. | Ho L et al. | β | 2010 | β |
| Control of embryonic stem cell identity by nucleosome remodeling enzymes. | Fazzio TG et al. | β | 2010 | β |
| Copy number variants at Williams-Beuren syndrome 7q11.23 region. | Merla G et al. | β | 2010 | β |
| Deconstructing repression: evolving models of co-repressor action. | Perissi V et al. | β | 2010 | β |
| Deletion of the Chd6 exon 12 affects motor coordination. | Lathrop MJ et al. | β | 2010 | β |
| Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways. | Riccio A | β | 2010 | β |
| Epigenetic reprogramming: enforcer or enabler of developmental fate? | Combes AN et al. | β | 2010 | β |
| Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. | Kidder BL et al. | β | 2010 | β |
| Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila. | Herr A et al. | β | 2010 | β |
| Genetics and development of neural tube defects. | Copp AJ et al. | β | 2010 | β |
| Germline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome. | Schneppenheim R et al. | β | 2010 | β |
| Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness. | Saladi SV et al. | β | 2010 | β |
| Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function. | Mallappa C et al. | β | 2010 | β |
| Neuregulin-1 modulates the differentiation of neural stem cells in vitro through an interaction with the Swi/Snf complex. | Pirotte D et al. | β | 2010 | β |
| Normal Adult Hippocampal Neurogenesis in SRG3-overexpressing Transgenic Mice. | Kim B et al. | β | 2010 | β |
| Purification of a novel RECQL5-SWI/SNF-RNAPII super complex. | Zhou G et al. | β | 2010 | β |
| Returning to the stem state: epigenetics of recapitulating pre-differentiation chromatin structure. | Shafa M et al. | β | 2010 | β |
| SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells. | Cohet N et al. | β | 2010 | β |
| SWI/SNF complexes, chromatin remodeling and skeletal myogenesis: it's time to exchange! | Albini S et al. | β | 2010 | β |
| SWItching on the transcriptional circuitry in melanoma. | Vinod Saladi S et al. | β | 2010 | β |
| The BRG1 ATPase of chromatin remodeling complexes is involved in modulation of mesenchymal stem cell senescence through RB-P53 pathways. | Alessio N et al. | β | 2010 | β |
| The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes. | Bakshi R et al. | β | 2010 | β |
| Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex. | Keppler BR et al. | β | 2010 | β |
| ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1. | SΓ‘nchez-TillΓ³ E et al. | β | 2010 | β |
| An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. | Ho L et al. | β | 2009 | β |
| Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation. | Flowers S et al. | β | 2009 | β |
| ATP-dependent chromatin remodeling in neural development. | Yoo AS et al. | β | 2009 | β |
| BRG1 and LKB1: tales of two tumor suppressor genes on chromosome 19p and lung cancer. | Rodriguez-Nieto S et al. | β | 2009 | β |
| BRG1 increases transcription of proinflammatory genes in renal ischemia. | Naito M et al. | β | 2009 | β |
| Chromatin remodeling complex in Treg function. | Jani A et al. | β | 2009 | β |
| Chromatin remodeling in embryonic stem cells: regulating the balance between pluripotency and differentiation. | Keenen B et al. | β | 2009 | β |
| Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF). | Yoshimura K et al. | β | 2009 | β |
| Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis. | Miao J et al. | β | 2009 | β |
| Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer. | Weissman B et al. | β | 2009 | β |
| Manipulation of SMARCA2 and SMARCA4 transcript levels in porcine embryos differentially alters development and expression of SMARCA1, SOX2, NANOG, and EIF1. | Magnani L et al. | β | 2009 | β |
| Marking time: the dynamic role of chromatin and covalent modification in transcription. | Reid G et al. | β | 2009 | β |
| Mi2beta shows chromatin enzyme specificity by erasing a DNase I-hypersensitive site established by ACF. | Ishii H et al. | β | 2009 | β |
| MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. | Yoo AS et al. | β | 2009 | β |
| N-terminally truncated BAF57 isoforms contribute to the diversity of SWI/SNF complexes in neurons. | Kazantseva A et al. | β | 2009 | β |
| Nuclear localization of ISWI ATPase Smarca5 (Snf2h) in mouse. | Vargova J et al. | β | 2009 | β |
| Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex. | Wang X et al. | β | 2009 | β |
| Role of chromatin states in transcriptional memory. | Kundu S et al. | β | 2009 | β |
| SWI/SNF-Brg1 regulates self-renewal and occupies core pluripotency-related genes in embryonic stem cells. | Kidder BL et al. | β | 2009 | β |
| SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity. | Bourgo RJ et al. | β | 2009 | β |
| The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a. | Becker TM et al. | β | 2009 | β |
| The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells. | Naidu SR et al. | β | 2009 | β |
| The SWI/SNF complex and cancer. | Reisman D et al. | β | 2009 | β |
| Transcriptional heterogeneity in mouse embryonic stem cells. | Tanaka TS | β | 2009 | β |
| Understanding the words of chromatin regulation. | Wu JI et al. | β | 2009 | β |
| A novel genetic strategy reveals unexpected roles of the Swi-Snf-like chromatin-remodeling BAF complex in thymocyte development. | Jani A et al. | β | 2008 | β |
| An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. | Fazzio TG et al. | β | 2008 | β |
| BAF250B-associated SWI/SNF chromatin-remodeling complex is required to maintain undifferentiated mouse embryonic stem cells. | Yan Z et al. | β | 2008 | β |
| BAF60a interacts with p53 to recruit the SWI/SNF complex. | Oh J et al. | β | 2008 | β |
| Baf60c is a component of the neural progenitor-specific BAF complex in developing retina. | Lamba DA et al. | β | 2008 | β |
| BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. | Kaeser MD et al. | β | 2008 | β |
| BRG1-mediated chromatin remodeling regulates differentiation and gene expression of T helper cells. | Wurster AL et al. | β | 2008 | β |
| Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54(nrb). | Ito T et al. | β | 2008 | β |
| Characterization of mammary tumors from Brg1 heterozygous mice. | Bultman SJ et al. | β | 2008 | β |
| Chromatin remodeling, development and disease. | Ko M et al. | β | 2008 | β |
| Chromatin remodelling and actin organisation. | Farrants AK | β | 2008 | β |
| Coronary development is regulated by ATP-dependent SWI/SNF chromatin remodeling component BAF180. | Huang X et al. | β | 2008 | β |
| Developmental capacity of porcine nuclear transfer embryos correlate with levels of chromatin-remodeling transcripts in donor cells. | Magnani L et al. | β | 2008 | β |
| Differentiation-specific expression of chromatin remodeling factor BRM. | Itoh T et al. | β | 2008 | β |
| Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. | Stankunas K et al. | β | 2008 | β |
| ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. | Gao X et al. | β | 2008 | β |
| Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. | Landry J et al. | β | 2008 | β |
| Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines. | Medina PP et al. | β | 2008 | β |
| Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program. | Xi Q et al. | β | 2008 | β |
| Genomic RNA profiling and the programme controlling preimplantation mammalian development. | Bell CE et al. | β | 2008 | β |
| Global transcription in pluripotent embryonic stem cells. | Efroni S et al. | β | 2008 | β |
| HAB1-SWI3B interaction reveals a link between abscisic acid signaling and putative SWI/SNF chromatin-remodeling complexes in Arabidopsis. | Saez A et al. | β | 2008 | β |
| Modeling neural tube defects in the mouse. | Zohn IE et al. | β | 2008 | β |
| Molecular and subcellular characterisation of oocytes screened for their developmental competence based on glucose-6-phosphate dehydrogenase activity. | Torner H et al. | β | 2008 | β |
| Neurologic phenotype of Schimke immuno-osseous dysplasia and neurodevelopmental expression of SMARCAL1. | Deguchi K et al. | β | 2008 | β |
| Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. | Wajapeyee N et al. | β | 2008 | β |
| Participation of Brahma-related gene 1 (BRG1)-associated factor 57 and BRG1-containing chromatin remodeling complexes in thyroid hormone-dependent gene activation during vertebrate development. | Heimeier RA et al. | β | 2008 | β |
| Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos. | Lin W et al. | β | 2008 | β |
| Pygopus and the Wnt signaling pathway: a diverse set of connections. | Jessen S et al. | β | 2008 | β |
| SRG3, a core component of mouse SWI/SNF complex, is essential for extra-embryonic vascular development. | Han D et al. | β | 2008 | β |
| Targeted knockout of BRG1 potentiates lung cancer development. | Glaros S et al. | β | 2008 | β |
| The BRG1 transcriptional coregulator. | Trotter KW et al. | β | 2008 | β |
| The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. | Griffin CT et al. | β | 2008 | β |
| Two subunits specific to the PBAP chromatin remodeling complex have distinct and redundant functions during drosophila development. | Carrera I et al. | β | 2008 | β |
| Zebrafish: a model system for the study of eye genetics. | Fadool JM et al. | β | 2008 | β |
| Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers. | Sun A et al. | β | 2007 | β |
| An adenosine triphosphatase of the sucrose nonfermenting 2 family, androgen receptor-interacting protein 4, is essential for mouse embryonic development and cell proliferation. | Zhang FP et al. | β | 2007 | β |
| An essential switch in subunit composition of a chromatin remodeling complex during neural development. | Lessard J et al. | β | 2007 | β |
| A novel model for an older remodeler: the BAF swap in neurogenesis. | Aigner S et al. | β | 2007 | β |
| A novel role of Brg1 in the regulation of SRF/MRTFA-dependent smooth muscle-specific gene expression. | Zhang M et al. | β | 2007 | β |
| Brg1 chromatin remodeling factor is involved in cell growth arrest, apoptosis and senescence of rat mesenchymal stem cells. | Napolitano MA et al. | β | 2007 | β |
| Chromatin and chromatin-modifying proteins in adipogenesis. | Musri MM et al. | β | 2007 | β |
| Chromatin-modifying proteins in cancer. | Fog CK et al. | β | 2007 | β |
| Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling. | Wang GG et al. | β | 2007 | β |
| Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis. | Ueda T et al. | β | 2007 | β |
| Developmental arrest induced in cleavage stage porcine embryos following microinjection of mRNA encoding Brahma (Smarca 2), a chromatin remodeling protein. | Magnani L et al. | β | 2007 | β |
| Expression of SRG3, a chromatin-remodelling factor, in the mouse oocyte and early preimplantation embryos. | Sun F et al. | β | 2007 | β |
| Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state. | Yamamichi N et al. | β | 2007 | β |
| Genetic and epigenetic mechanisms of gene regulation during lens development. | Cvekl A et al. | β | 2007 | β |
| Genetic and epigenetic regulators of pluripotency. | Surani MA et al. | β | 2007 | β |
| Genomic and functional evidence for an ARID1A tumor suppressor role. | Huang J et al. | β | 2007 | β |
| HMGA1 mediates the activation of the CRYAB promoter by BRG1. | Duncan B et al. | β | 2007 | β |
| How is pluripotency determined and maintained? | Niwa H | β | 2007 | β |
| How many remodelers does it take to make a brain? Diverse and cooperative roles of ATP-dependent chromatin-remodeling complexes in development. | Brown E et al. | β | 2007 | β |
| Interplay between chromatin remodelers and protein arginine methyltransferases. | Pal S et al. | β | 2007 | β |
| Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects. | Harris MJ et al. | β | 2007 | β |
| Myogenin and the SWI/SNF ATPase Brg1 maintain myogenic gene expression at different stages of skeletal myogenesis. | Ohkawa Y et al. | β | 2007 | β |
| Nuclear Receptor Cofactors in PPARgamma-Mediated Adipogenesis and Adipocyte Energy Metabolism. | Powell E et al. | β | 2007 | β |
| Regulation of dendritic development by neuron-specific chromatin remodeling complexes. | Wu JI et al. | β | 2007 | β |
| Rybp, a polycomb complex-associated protein, is required for mouse eye development. | Pirity MK et al. | β | 2007 | β |
| SRG3 interacts directly with the major components of the SWI/SNF chromatin remodeling complex and protects them from proteasomal degradation. | Sohn DH et al. | β | 2007 | β |
| SWI/SNF chromatin remodeling and linker histones in plants. | Jerzmanowski A | β | 2007 | β |
| SWI/SNF chromatin remodeling ATPase Brm regulates the differentiation of early retinal stem cells/progenitors by influencing Brn3b expression and Notch signaling. | Das AV et al. | β | 2007 | β |
| The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes. | Xu Y et al. | β | 2007 | β |
| The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor. | Flajollet S et al. | β | 2007 | β |
| The regulation of ATP-dependent nucleosome remodelling factors. | Hogan C et al. | β | 2007 | β |
| Transcriptional control of erythropoiesis: emerging mechanisms and principles. | Kim SI et al. | β | 2007 | β |
| Unwinding chromatin for development and growth: a few genes at a time. | Kwon CS et al. | β | 2007 | β |
| A role for chromatin remodeling in regulation of CUC gene expression in the Arabidopsis cotyledon boundary. | Kwon CS et al. | β | 2006 | β |
| BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression. | Ooi L et al. | β | 2006 | β |
| Brg1 is required for murine neural stem cell maintenance and gliogenesis. | Matsumoto S et al. | β | 2006 | β |
| Brg1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for myeloid differentiation to granulocytes. | Vradii D et al. | β | 2006 | β |
| Changes in attitude, changes in latitude: nuclear receptors remodeling chromatin to regulate transcription. | Chen J et al. | β | 2006 | β |
| Chromatin in pluripotent embryonic stem cells and differentiation. | Meshorer E et al. | β | 2006 | β |
| Chromatin remodelling in mammalian differentiation: lessons from ATP-dependent remodellers. | de la Serna IL et al. | β | 2006 | β |
| Chromatin remodelling: the industrial revolution of DNA around histones. | Saha A et al. | β | 2006 | β |
| Cooperative activity of BRG1 and Z-DNA formation in chromatin remodeling. | Liu H et al. | β | 2006 | β |
| Critical role of Brg1 member of the SWI/SNF chromatin remodeling complex during neurogenesis and neural crest induction in zebrafish. | Eroglu B et al. | β | 2006 | β |
| DNA-binding properties of the recombinant high-mobility-group-like AT-hook-containing region from human BRG1 protein. | Singh M et al. | β | 2006 | β |
| Downregulation of BRG-1 repressed expression of CD44s in cervical neuroendocrine carcinoma and adenocarcinoma. | Kuo KT et al. | β | 2006 | β |
| Epigenetic aberrations and cancer. | Ducasse M et al. | β | 2006 | β |
| Epigenetic alterations of BRG1 leads to cancer development through its nuclear-cytoplasmic shuttling abnormalities. | Gunduz E et al. | β | 2006 | β |
| Functions of histone-modifying enzymes in development. | Lin W et al. | β | 2006 | β |
| Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland. | Mussi P et al. | β | 2006 | β |
| Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex. | Klochendler-Yeivin A et al. | β | 2006 | β |
| Maternal BRG1 regulates zygotic genome activation in the mouse. | Bultman SJ et al. | β | 2006 | β |
| Molecular genetic analysis of an SNF2/brahma-related gene in Tetrahymena thermophila suggests roles in growth and nuclear development. | Fillingham JS et al. | β | 2006 | β |
| Nuclear receptor mediated gene regulation through chromatin remodeling and histone modifications. | Kishimoto M et al. | β | 2006 | β |
| Recruitment of the SWI/SNF protein Brg1 by a multiprotein complex effects transcriptional repression in murine erythroid progenitors. | Xu Z et al. | β | 2006 | β |
| Regulation of alphaA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin. | Yang Y et al. | β | 2006 | β |
| Role for Brm in cell growth control. | Coisy-Quivy M et al. | β | 2006 | β |
| Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote. | Torres-Padilla ME et al. | β | 2006 | β |
| Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. | Ramirez-Carrozzi VR et al. | β | 2006 | β |
| Targeted disruption of the synovial sarcoma-associated SS18 gene causes early embryonic lethality and affects PPARBP expression. | de Bruijn DR et al. | β | 2006 | β |
| The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes. | de la Serna IL et al. | β | 2006 | β |
| The N-terminal ATPase AT-hook-containing region of the Arabidopsis chromatin-remodeling protein SPLAYED is sufficient for biological activity. | Su Y et al. | β | 2006 | β |
| The tumour suppressor hSNF5/INI1 controls the differentiation potential of malignant rhabdoid cells. | Albanese P et al. | β | 2006 | β |
| Totipotency, cell differentiation and reprogramming in humans. | Hansis C | β | 2006 | β |
| Zimp7 and Zimp10, two novel PIAS-like proteins, function as androgen receptor coregulators. | Beliakoff J et al. | β | 2006 | β |
| A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. | Bultman SJ et al. | β | 2005 | β |
| Apical role for BRG1 in cytokine-induced promoter assembly. | Ni Z et al. | β | 2005 | β |
| ATP-dependent chromatin remodeling complexes and their role in nuclear receptor-dependent transcription in vivo. | Aoyagi S et al. | β | 2005 | β |
| BAF57 governs androgen receptor action and androgen-dependent proliferation through SWI/SNF. | Link KA et al. | β | 2005 | β |
| BRG1 loss in MiaPaCa2 cells induces an altered cellular morphology and disruption in the organization of the actin cytoskeleton. | Rosson GB et al. | β | 2005 | β |
| Composition and functional specificity of SWI2/SNF2 class chromatin remodeling complexes. | Mohrmann L et al. | β | 2005 | β |
| Controlling nuclear receptors: the circular logic of cofactor cycles. | Perissi V et al. | β | 2005 | β |
| Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo. | Park SE et al. | β | 2005 | β |
| Histone modifying and chromatin remodelling enzymes in cancer and dysplastic syndromes. | Gibbons RJ | β | 2005 | β |
| Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway. | Eissenberg JC et al. | β | 2005 | β |
| Lsh, a guardian of heterochromatin at repeat elements. | Muegge K | β | 2005 | β |
| Modulation of androgen receptor transactivation by the SWI3-related gene product (SRG3) in multiple ways. | Hong CY et al. | β | 2005 | β |
| Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome. | Alhopuro P et al. | β | 2005 | β |
| MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex. | de la Serna IL et al. | β | 2005 | β |
| Regulation of chromatin structure during thymic T cell development. | Winandy S | β | 2005 | β |
| Rybp/DEDAF is required for early postimplantation and for central nervous system development. | Pirity MK et al. | β | 2005 | β |
| SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas. | Modena P et al. | β | 2005 | β |
| SWI3 subunits of putative SWI/SNF chromatin-remodeling complexes play distinct roles during Arabidopsis development. | Sarnowski TJ et al. | β | 2005 | β |
| SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. | Young DW et al. | β | 2005 | β |
| Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation. | Indra AK et al. | β | 2005 | β |
| The BRG1- and hBRM-associated factor BAF57 induces apoptosis by stimulating expression of the cylindromatosis tumor suppressor gene. | Wang L et al. | β | 2005 | β |
| The Brm gene suppressed at the post-transcriptional level in various human cell lines is inducible by transient HDAC inhibitor treatment, which exhibits antioncogenic potential. | Yamamichi N et al. | β | 2005 | β |
| The expression of the SWI/SNF ATPase subunits BRG1 and BRM in normal human tissues. | Reisman DN et al. | β | 2005 | β |
| The p270 (ARID1A/SMARCF1) subunit of mammalian SWI/SNF-related complexes is essential for normal cell cycle arrest. | Nagl NG et al. | β | 2005 | β |
| The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation. | Gresh L et al. | β | 2005 | β |
| The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD. | Seo S et al. | β | 2005 | β |
| Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells. | Medina PP et al. | β | 2005 | β |
| Tumour suppressor retinoblastoma protein Rb: a transcriptional regulator. | Zhu L | β | 2005 | β |
| WUSCHEL is a primary target for transcriptional regulation by SPLAYED in dynamic control of stem cell fate in Arabidopsis. | Kwon CS et al. | β | 2005 | β |
| A BAF-centred view of the immune system. | Chi T | β | 2004 | β |
| ATP-dependent nucleosome remodeling complexes: enzymes tailored to deal with chromatin. | Sif S | β | 2004 | β |
| BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2. | Hill DA et al. | β | 2004 | β |
| BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI. | Kang H et al. | β | 2004 | β |
| Brg-1 is required for maximal transcription of the human matrix metalloproteinase-2 gene. | Ma Z et al. | β | 2004 | β |
| Bruton's tyrosine kinase (Btk) enhances transcriptional co-activation activity of BAM11, a Btk-associated molecule of a subunit of SWI/SNF complexes. | Hirano M et al. | β | 2004 | β |
| Chromatin modifiers and carcinogenesis. | Gregory RI et al. | β | 2004 | β |
| Epigenetics and cancer. | Lund AH et al. | β | 2004 | β |
| Expression of genes encoding chromatin regulatory factors in developing rhesus monkey oocytes and preimplantation stage embryos: possible roles in genome activation. | Zheng P et al. | β | 2004 | β |
| Expression of p270 (ARID1A), a component of human SWI/SNF complexes, in human tumors. | Wang X et al. | β | 2004 | β |
| Genetic and epigenetic screening for gene alterations of the chromatin-remodeling factor, SMARCA4/BRG1, in lung tumors. | Medina PP et al. | β | 2004 | β |
| Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme. | Hill DA et al. | β | 2004 | β |
| Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymes. | Doan DN et al. | β | 2004 | β |
| Modifying chromatin to permit steroid hormone receptor-dependent transcription. | Kinyamu HK et al. | β | 2004 | β |
| Nuclear receptor coregulators are new players in nervous system development and function. | Nishihara E et al. | β | 2004 | β |
| Nuclear reprogramming of human somatic cells by xenopus egg extract requires BRG1. | Hansis C et al. | β | 2004 | β |
| P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells. | Oruetxebarria I et al. | β | 2004 | β |
| Pre-implantation conceptus and maternal uterine communications: molecular events leading to successful implantation. | Imakawa K et al. | β | 2004 | β |
| Role for BRG1 in cell cycle control and tumor suppression. | Hendricks KB et al. | β | 2004 | β |
| Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene. | Wang F et al. | β | 2004 | β |
| SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex. | Zraly CB et al. | β | 2004 | β |
| Temporal recruitment of transcription factors and SWI/SNF chromatin-remodeling enzymes during adipogenic induction of the peroxisome proliferator-activated receptor gamma nuclear hormone receptor. | Salma N et al. | β | 2004 | β |
| The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest. | MΓΌller C et al. | β | 2004 | β |
| The SWI/SNF complex--chromatin and cancer. | Roberts CW et al. | β | 2004 | β |
| Two related ARID family proteins are alternative subunits of human SWI/SNF complexes. | Wang X et al. | β | 2004 | β |
| VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection. | Herrera FJ et al. | β | 2004 | β |
| CHB2, a member of the SWI3 gene family, is a global regulator in Arabidopsis. | Zhou C et al. | β | 2003 | β |
| Differential requirement of SWI/SNF for androgen receptor activity. | Marshall TW et al. | β | 2003 | β |
| Growth inhibition by the mammalian SWI-SNF subunit Brm is regulated by acetylation. | Bourachot B et al. | β | 2003 | β |
| mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. | Pal S et al. | β | 2003 | β |
| Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. | Nie Z et al. | β | 2003 | β |
| Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation. | Gregg RG et al. | β | 2003 | β |
| Selective gene regulation by SWI/SNF-related chromatin remodeling factors. | Katsani KR et al. | β | 2003 | β |
| Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. | Chi TH et al. | β | 2003 | β |
| The high-mobility-group box protein SSRP1/T160 is essential for cell viability in day 3.5 mouse embryos. | Cao S et al. | β | 2003 | β |
| The ISWI ATPase Snf2h is required for early mouse development. | Stopka T et al. | β | 2003 | β |
| The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T cell development. | Gebuhr TC et al. | β | 2003 | β |
| The SWI/SNF family of ATP-dependent chromatin remodelers: similar mechanisms for diverse functions. | Wang W | β | 2003 | β |
| Thymocyte development: drama without Brahma. | Clevers H | β | 2003 | β |
| Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes. | Kadam S et al. | β | 2003 | β |
| A comparative cDNA microarray analysis reveals a spectrum of genes regulated by Pax6 in mouse lens. | Chauhan BK et al. | β | 2002 | β |
| A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle. | Versteege I et al. | β | 2002 | β |
| ATP-dependent nucleosome remodeling. | Becker PB et al. | β | 2002 | β |
| Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex. | Kuroda Y et al. | β | 2002 | β |
| Chromatin modification and epigenetic reprogramming in mammalian development. | Li E | β | 2002 | β |
| Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes. | Huang M et al. | β | 2002 | β |
| Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling. | Strobeck MW et al. | β | 2002 | β |
| Concomitant down-regulation of BRM and BRG1 in human tumor cell lines: differential effects on RB-mediated growth arrest vs CD44 expression. | Reisman DN et al. | β | 2002 | β |
| Expression of BRG1, a human SWI/SNF component, affects the organisation of actin filaments through the RhoA signalling pathway. | Asp P et al. | β | 2002 | β |
| Expression of ISWI and its binding to chromatin during the cell cycle and early development. | Demeret C et al. | β | 2002 | β |
| Functional involvement of the Brahma/SWI2-related gene 1 protein in cytochrome P4501A1 transcription mediated by the aryl hydrocarbon receptor complex. | Wang S et al. | β | 2002 | β |
| Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. | Roberts CW et al. | β | 2002 | β |
| Identification of a polymorphic, neuron-specific chromatin remodeling complex. | Olave I et al. | β | 2002 | β |
| Interferon-gamma-induced chromatin remodeling at the CIITA locus is BRG1 dependent. | Pattenden SG et al. | β | 2002 | β |
| Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors. | Inoue H et al. | β | 2002 | β |
| Mechanisms of chromatin assembly and transcription. | Kadam S et al. | β | 2002 | β |
| Nuclear actin and actin-related proteins in chromatin remodeling. | Olave IA et al. | β | 2002 | β |
| Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. | Chi TH et al. | β | 2002 | β |
| Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G1 arrest associated with induction of p16ink4a and activation of RB. | Betz BL et al. | β | 2002 | β |
| SPLAYED, a novel SWI/SNF ATPase homolog, controls reproductive development in Arabidopsis. | Wagner D et al. | β | 2002 | β |
| SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription. | Lee D et al. | β | 2002 | β |
| SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. | Kato H et al. | β | 2002 | β |
| The Drosophila BRM complex facilitates global transcription by RNA polymerase II. | Armstrong JA et al. | β | 2002 | β |
| The in vivo functions of ATP-dependent chromatin-remodelling factors. | Tsukiyama T | β | 2002 | β |
| The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in culture. | Roy K et al. | β | 2002 | β |
| The viral oncogene human papillomavirus E7 deregulates transcriptional silencing by Brm-related gene 1 via molecular interactions. | Lee D et al. | β | 2002 | β |
| When the embryonic genome flexes its muscles. | Rupp RA et al. | β | 2002 | β |
| Above and within the genome: epigenetics past and present. | Urnov FD et al. | β | 2001 | β |
| Chromatin remodeling enzymes: who's on first? | Fry CJ et al. | β | 2001 | β |
| Chromatin remodeling in development and differentiation. | MΓΌller C et al. | β | 2001 | β |
| Cloning and characterization of the murine Imitation Switch (ISWI) genes: differential expression patterns suggest distinct developmental roles for Snf2h and Snf2l. | Lazzaro MA et al. | β | 2001 | β |
| Essential roles of Snf5p in Snf-Swi chromatin remodeling in vivo. | Geng F et al. | β | 2001 | β |
| Generation of the dominant-negative mutant of hArpNbeta: a component of human SWI/SNF chromatin remodeling complex. | Choi EY et al. | β | 2001 | β |
| Linking the Rb and polycomb pathways. | Dahiya A et al. | β | 2001 | β |
| LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest. | Marignani PA et al. | β | 2001 | β |
| Lsh, a SNF2 family member, is required for normal murine development. | Geiman TM et al. | β | 2001 | β |
| Mechanisms for ATP-dependent chromatin remodelling. | Flaus A et al. | β | 2001 | β |
| Mutation analyses of 268 candidate genes in human tumor cell lines. | Teng DH et al. | β | 2001 | β |
| Notch1 confers a resistance to glucocorticoid-induced apoptosis on developing thymocytes by down-regulating SRG3 expression. | Choi YI et al. | β | 2001 | β |
| Selectivity of chromatin-remodelling cofactors for ligand-activated transcription. | Lemon B et al. | β | 2001 | β |
| Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development. | Kim JK et al. | β | 2001 | β |
| Toti-/pluripotential stem cells and epigenetic modifications. | Tada T et al. | β | 2001 | β |
| When the SWI/SNF complex remodels...the cell cycle. | Muchardt C et al. | β | 2001 | β |
| The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression. | Klochendler-Yeivin A et al. | β | 2000 | β |