Identification of a polymorphic, neuron-specific chromatin remodeling complex.
paper
Cited
Public
Unavailable
- Authors
- Olave, Ivan; Wang, Weidong; Xue, Yutong; Kuo, Ann; Crabtree, Gerald R
- Year
- 2002
- Journal
- Genes & development
- PMID
- 12368262
- DOI
- 10.1101/gad.992102
- PMCID
- PMC187451
A variety of chromatin remodeling complexes are thought to assist sequence-specific transcription factors. The complexes described to date are expressed ubiquitously, suggesting that they have general transcriptional functions. We show that vertebrate neurons have a specialized chromatin remodeling complex, bBAF, specifically containing the actin-related protein, BAF53b, which is first expressed in postmitotic neurons at about murine embryonic day 12.5 (E12.5). BAF53b is combinatorially assembled into polymorphic complexes with ubiquitous subunits including the two ATPases BRG1 and BRM. We speculate that bBAF complexes create neuronal-specific patterns of chromatin accessibility, thereby imparting new regulatory characteristics to ubiquitous sequence-specific transcription factors in neurons.
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| Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders. | De Toma I et al. | β | 2016 | β |
| Generation of BAF53b-Cre transgenic mice with pan-neuronal Cre activities. | Zhan X et al. | β | 2015 | β |
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| Embedding the Future of Regenerative Medicine into the Open Epigenomic Landscape of Pluripotent Human Embryonic Stem Cells. | Parsons XH | β | 2013 | β |
| Epigenetic layers and players underlying neurodevelopment. | LaSalle JM et al. | β | 2013 | β |
| NF-ΞΊB forms a complex with the chromatin remodeler BRG1 to regulate Schwann cell differentiation. | Limpert AS et al. | β | 2013 | β |
| Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. | Kadoch C et al. | β | 2013 | β |
| Reprogramming human fibroblasts to neurons by recapitulating an essential microRNA-chromatin switch. | Tang J et al. | β | 2013 | β |
| Rhabdoid tumors: an initial clue to the role of chromatin remodeling in cancer. | Lee RS et al. | β | 2013 | β |
| Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. | Shi J et al. | β | 2013 | β |
| The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. | Vogel-Ciernia A et al. | β | 2013 | β |
| BET domain co-regulators in obesity, inflammation and cancer. | Belkina AC et al. | β | 2012 | β |
| Diverse functions of ATP-dependent chromatin remodeling complexes in development and cancer. | Wu JI | β | 2012 | β |
| Epigenetic regulation of axon and dendrite growth. | Trakhtenberg EF et al. | β | 2012 | β |
| Heterocomplex formation by Arp4 and Ξ²-actin is involved in the integrity of the Brg1 chromatin remodeling complex. | Nishimoto N et al. | β | 2012 | β |
| Regulation of gene expression during early neuronal differentiation: evidence for patterns conserved across neuron populations and vertebrate classes. | Ernsberger U | β | 2012 | β |
| The Dynamics of Global Chromatin Remodeling are Pivotal for Tracking the Normal Pluripotency of Human Embryonic Stem Cells. | Parsons XH | β | 2012 | β |
| Actin-related proteins localized in the nucleus: from discovery to novel roles in nuclear organization. | Oma Y et al. | β | 2011 | β |
| Varying modulation of HIV-1 LTR activity by Baf complexes. | Van Duyne R et al. | β | 2011 | β |
| Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system. | Zibetti C et al. | β | 2010 | β |
| An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis. | Denis GV et al. | β | 2010 | β |
| Chromatin dynamics associated with HIV-1 Tat-activated transcription. | Easley R et al. | β | 2010 | β |
| Large-scale in silico modeling of metabolic interactions between cell types in the human brain. | Lewis NE et al. | β | 2010 | β |
| Transcription through the HIV-1 nucleosomes: effects of the PBAF complex in Tat activated transcription. | Easley R et al. | β | 2010 | β |
| An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. | Ho L et al. | β | 2009 | β |
| Chapter 5. Nuclear actin-related proteins in epigenetic control. | Meagher RB et al. | β | 2009 | β |
| Contributions of extracellular matrix signaling and tissue architecture to nuclear mechanisms and spatial organization of gene expression control. | LeliΓ¨vre SA | β | 2009 | β |
| Functional genomics of HMGN3a and SMARCAL1 in early mammalian embryogenesis. | Uzun A et al. | β | 2009 | β |
| Interaction of estrogen receptor-alpha ligand binding domain with nuclear proteins of aging mouse brain. | Ghosh S et al. | β | 2009 | β |
| In vitro nuclear interactome of the HIV-1 Tat protein. | Gautier VW et al. | β | 2009 | β |
| N-terminally truncated BAF57 isoforms contribute to the diversity of SWI/SNF complexes in neurons. | Kazantseva A et al. | β | 2009 | β |
| Role of chromatin states in transcriptional memory. | Kundu S et al. | β | 2009 | β |
| BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. | Kaeser MD et al. | β | 2008 | β |
| Zebrafish: a model system for the study of eye genetics. | Fadool JM et al. | β | 2008 | β |
| An essential switch in subunit composition of a chromatin remodeling complex during neural development. | Lessard J et al. | β | 2007 | β |
| A novel model for an older remodeler: the BAF swap in neurogenesis. | Aigner S et al. | β | 2007 | β |
| Mechanisms of ATP dependent chromatin remodeling. | Gangaraju VK et al. | β | 2007 | β |
| Regulation of dendritic development by neuron-specific chromatin remodeling complexes. | Wu JI et al. | β | 2007 | β |
| SWI/SNF chromatin remodeling ATPase Brm regulates the differentiation of early retinal stem cells/progenitors by influencing Brn3b expression and Notch signaling. | Das AV et al. | β | 2007 | β |
| Switching of the core transcription machinery during myogenesis. | Deato MD et al. | β | 2007 | β |
| Chromatin remodelling in mammalian differentiation: lessons from ATP-dependent remodellers. | de la Serna IL et al. | β | 2006 | β |
| HMGN1 is dispensable for myogenesis and adipogenesis. | Hill DA et al. | β | 2006 | β |
| Maternal BRG1 regulates zygotic genome activation in the mouse. | Bultman SJ et al. | β | 2006 | β |
| Vertebrate Arp6, a novel nuclear actin-related protein, interacts with heterochromatin protein 1. | Ohfuchi E et al. | β | 2006 | β |
| Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping. | Roh TY et al. | β | 2005 | β |
| Characterization of the neuronal marker NeuN as a multiply phosphorylated antigen with discrete subcellular localization. | Lind D et al. | β | 2005 | β |
| Differential display of proteins involved in the neural differentiation of mouse embryonic carcinoma P19 cells by comparative proteomic analysis. | An J et al. | β | 2005 | β |
| eXPRESSION: an in silico tool to predict patterns of gene expression. | Ferguson DA et al. | β | 2005 | β |
| Neural and eye-specific defects associated with loss of the imitation switch (ISWI) chromatin remodeler in Xenopus laevis. | Dirscherl SS et al. | β | 2005 | β |
| A BAF-centred view of the immune system. | Chi T | β | 2004 | β |
| ATP-dependent nucleosome remodeling complexes: enzymes tailored to deal with chromatin. | Sif S | β | 2004 | β |
| Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymes. | Doan DN et al. | β | 2004 | β |
| Polybromo protein BAF180 functions in mammalian cardiac chamber maturation. | Wang Z et al. | β | 2004 | β |
| Regulatory diversity among metazoan co-activator complexes. | Taatjes DJ et al. | β | 2004 | β |
| Temporal recruitment of transcription factors and SWI/SNF chromatin-remodeling enzymes during adipogenic induction of the peroxisome proliferator-activated receptor gamma nuclear hormone receptor. | Salma N et al. | β | 2004 | β |
| Chromatin remodeling and human disease. | Huang C et al. | β | 2003 | β |
| Neurogenesis and the cell cycle. | Ohnuma S et al. | β | 2003 | β |
| Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. | Nie Z et al. | β | 2003 | β |
| The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP. | Oma Y et al. | β | 2003 | β |