Here we describe a centralized database and web interface, LD Hub, which automates the LD score regression analysis pipeline using publically available GWAS summary-level data of individuals with European ancestry. Users of our web-based tool only need to upload summary results for their trait(s) of interest; and the web server will automatically test their results against GWAS results from (currently) 173 other traits/diseases. The proposed database and web interface calculates the SNP heritability for the uploaded phenotype(s), and a genetic correlation matrix across traits. LD Hub allows the user to conduct the analysis on specific phenotypes only or perform a hypothesis free screen across all traits in the database (Table 1). Users have the option of uploading their own results files and the option of adding their GWAS results to the database for inclusion in future releases. The resource is continuously updated and curated every month to include new results from users and publicly available sources alike. The pre-computed genetic correlation matrix will be provided on LD-Hub for all traits included in the database.
