The chief limitation of using LD score regression to estimate genetic correlations to date has been a practical one. Publicly available GWAS meta-analysis results are available from a number of different repositories on the Internet. It is time consuming to locate and download all of these resources for use, particularly as these databases become more numerous. What’s more, each summary results file typically involves different file formats and conventions making data preparation a time consuming exercise. In addition, many GWAS meta-analyses are not made publicly available, requiring the user to proactively invite the relevant investigators to share their results, which also takes a significant amount of time.
