The mPFC shares several pathways with the DRN and PAG that the vHip does not; these include stress responsive and immune responsive pathways, such as NRF2-mediated oxidative stress response, acute phase response, IL1-signaling, LPS-stimulated MAPK signaling, IL-6 signaling (Supplemental Table 4). In addition to these stress and immune pathways, some signaling pathways are also shared by mPFC, DRN and PAG: GABA receptor signaling, RAR activation, Rac and RhoGDI signaling, P2Y purinergic receptor signaling pathway, GDNF family ligand-receptor, IGF1 signaling, and PPAR signaling. Norepinephrine also appears to be active in all three regions (Supplemental Table 4).
