In addition to age associations, we also observed higher rates of alcohol-induced deaths among more recent birth cohorts of non-Latino white and AIAN men and women (eFigure 3 in the Supplement). Relative to the reference cohort (ie, those born in 1958), the cohort rate ratio increased among white men to 2.76 (95% CI, 2.41-3.16) for the cohort born in 1986, while the cohort rate ratio among white women was 6.92 (95% CI, 5.34-8.98) for the cohort born in 1989. Among AIAN men, the corresponding rate ratio was 4.97 (95% CI, 3.49-7.09) for the cohort born in 1986, while among AIAN women the rate ratio was 5.29 (95% CI, 3.06-9.13) for those born in 1988. Increases also tended to be larger in the most recent periods (eFigure 4 in the Supplement). Relative to 2008 (ie, the midpoint of our study), the rate ratio among men progressively increased from 1.03 (2010 vs 2008) to 1.31 (2016 vs 2008), while the corresponding rate ratios among women increased from 1.10 to 1.58.
