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Chunk #62 — Materials and Methods — Analysis of Interregional Functional Connectivity Changes with Development

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Development of large-scale functional brain networks in children.
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Next we examined regional correlation values (connectivity) in the two groups. We compared regional correlation values aggregated across the 4,005 pairs of anatomical regions, between young-adults and children. No significant between-group differences in the aggregated correlation values were observed. On the basis of this observation, subsequently, individual regional correlation values were z-transformed followed by centering of the distribution around zero mean. These normalized correlation values were compared between the two subject groups. t-Test with a false discovery rate of 0.005 was used to test for significant differences.