To further characterize regional differences in network organization, we examined the regional connectivity at divisional level: association, limbic, paralimbic, primary, and subcortical. Differences in mean correlation coefficients for 4,005 pairs were aggregated into 15 pairs and the resulting differences were then normalized. (see also [101]). First, interregional pairs that showed statistically significant (p<0.01, FDR corrected) increased or decreased functional connectivity in young-adults group compared to child group were identified as (+1) or (−1), respectively. Second, the number of decreased (−1) or increased connectivities (+1) for each of the 15 pairs was counted. For example, to identify differential connectivity between the association division and the subcortical division, the number of decreased or increased connectivities between all pairs of subregions belonging to the association division and subcortical division was counted. Finally, since each brain region has a different number of subregions, the aggregated differential connectivity count was normalized by the number of possible connections between pairs of subregions belonging to the two divisions under investigation.
