(a) The network of proteins with which PCLO interacts in its role at the presynaptic cytoskeletal matrix is relatively well-characterized, and we reasoned that genes encoding these proteins might harbor risk or protective variants. We assessed this hypothesis by testing for association conditioning on the PCLO nsSNP rs2522833 (i.e., investigating whether controlling statistically for the effect of rs2522833 increases the salience of other SNP associations), assessing the minimum p-value per gene, and then comparing this list to a list of 54 genes that make proteins that interact with PCLO. This analysis did not reveal any SNPs or genes whose significance was markedly lower than without including rs2522833 in the logistic regression model. Moreover, no known PCLO interacting protein was notable on this list.
