(b) We imputed genotypes for 2,037,829 autosomal SNPs using MACH with reference to HapMap CEU genotypes. The resulting lambda was 1.048, and the minimum p-value was 1.21×10−7. As noted above, 22 of the 25 most significant imputed associations were in the PCLO region. Investigation of SNP clustering that accounted for LD yielded results similar to those shown in Table 3.
