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Chunk #40 — Results — Secondary analyses

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Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.
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(c) We assembled a list of 103 candidate genes that had been studied for association with MDD in the literature (81). Nineteen of these genes had no SNPs within its transcript and another 9 genes had inadequate coverage (>1 SNP/15 kb; Supplemental Table 17). Of the remaining 75 genes, only NOS1 (neuronal nitric oxide synthase, p=0.0006) had p<0.001. However, NOS1 (as with most genes in Supplemental Table 16) is quite large and chance is a prominent potential influence on these results.