There is increasing recognition that genetic and environmental influences for many outcomes are likely to interface in complex ways. Interplay between genes and environment include processes of gene-environment interaction (GxE), or the extent to which measured environmental factors moderate genetic influences on a behavior, as well as gene-environment correlation (rGE), or the degree to which exposure to certain environmental conditions is due to genetic influences (Scarr & Mccartney, 1983). Thus even after all genetic variants with a main effect on AUD have been discovered, it will be important to understand their effects in the context of different environments.
