al., 2013), functional differences in brain reward systems (Heitzeg et al., 2014), and personality traits like impulsivity (Villafuerte et al., 2013; Li et al., 2017). Functional annotation of the genetic and biological processes implicated by GWAS variants (Clark et al., 2017; Edwards et al., 2015a) can also serve to improve our understanding of the many mechanisms leading from genes to complex behaviors.