Chunk #21 — Results — Partitioned Analysis by Chromosome

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Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.

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For both the TS and OCD phenotypes, the summed total of individual “by chromosome” heritability estimates (h2 TS = 0.61, h2 OCD = 0.35) were not different than the global univariate heritability estimates (h2 TS = 0.58, h2 OCD = 0.37) (Table S5 and S6). These results suggest that population stratification was appropriately controlled in these analyses.