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Chunk #50 — RESULTS — Dynamics of PAC during Transitions between Different Movement States

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Cross-frequency phase-amplitude coupling in repetitive movements in patients with Parkinson's disease.
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We also investigated PAC dynamics in slow tapping movement cycles in a manner similar to the pressing task. Since the presence or absence of color feedback had no significant effects on the PAC values in slow tapping, the evaluation of PAC dynamics was based on combining the two conditions. Similar to the pressing task, we found marked modulation of dynPAC in the slow tapping task. As shown in Fig. 5D, PAC declined from a brief maximum before index finger extension onset to post extension onset in controls. After reaching a minimum, when the index finger was above the higher amplitude threshold, PAC started to rebound and increased toward the postoffset period. Although the modulation pattern was generally similar in patients, it was markedly flattened compared with controls (also evident in Fig. 4). A two-way mixed ANOVA (dynPAC ∼ group × period) revealed a significant two-way interaction between group and period [F(4,148) = 3.59, P = 0.008]. This finding indicated that PAC was modulated differently in patients and controls. Therefore, we applied one-way ANOVA on the effect of period for patients