Chunk #11 — Background — Data generation

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Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype.

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We generated four populations, each with the same underlying population parameters. Three of the populations differed in diagnostic criteria used to ascertain the families. One population was collected solely on the basis of large dense pedigrees.