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Chunk #2 — INTRODUCTION

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The genetics of substance dependence.
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Other psychoactive substances, such as cannabis, cocaine, and opioids, also cause significant health and social problems for both the people who use them and their families. According to data from the United Nations Office on Drugs and Crime, 149–271 million people worldwide aged 15–64 used an illicit drug in 2009; of these, 15–39 million were classified as problem users (31). In the SAMHSA survey (119a), an estimated 22.6 million Americans aged 12 or older reported having used an illicit drug in 2010 during the month prior to the survey interview; of these, 2.9 million abused or were dependent on both alcohol and illicit drugs, and 4.2 million abused or were dependent on illicit drugs but not alcohol. Major health consequences of illicit drug use include accidental and intended injury, drug-induced psychotic symptoms, and increased risk for heart, liver, and lung diseases (31). A World Health Organization report (144) indicated that in 2004, an estimated 0.7% of the global burden of disease resulted from cocaine and opioid use.