In summary, these analyses provide evidence that parental EB exposure increases risk for young adult AUD regardless of the timing of that exposure with respect to the child’s developmental period. Thus, there was no evidence of “sensitive periods” of exposure to parental EB. Furthermore, we demonstrate that cumulative exposure in the form of having at least one affected parent across multiple developmental time frames increases risk. Family-based interventions to serve adults with AUD, drug abuse and criminal histories, as well as their children, are needed to help prevent the development of AUD in young adults.