Time-specific and cumulative effects of exposure to parental externalizing behavior on risk for young adult alcohol use disorder.
- Authors
- Edwards, Alexis C; Lönn, Sara L; Karriker-Jaffe, Katherine J; Sundquist, Jan; Kendler, Kenneth S; Sundquist, Kristina
- Year
- 2017
- Journal
- Addictive behaviors
- PMID
- 28319814
- DOI
- 10.1016/j.addbeh.2017.03.002
- PMCID
- PMC5457320
BACKGROUND: Previous studies indicate that parental externalizing behavior (EB) is a robust risk factor for alcohol use disorder (AUD) in their children, and that this is due to both inherited genetic liability and environmental exposure. However, it remains unclear whether the effects of exposure to parental EB vary as a function of timing and/or chronicity. METHODS: We identified biological parents with an alcohol use disorder, drug abuse, or criminal behavior, during different periods of their child's upbringing, using Swedish national registries. Logistic regression was used to determine whether the effect of parental EB exposure during different developmental periods differentially impacted children's risk for young adult AUD (ages 19-24). In addition, we tested how multiply affected parents and/or sustained exposure to affected parents impacted risk. RESULTS: While parental EB increased risk for young adult AUD, timing of exposure did not differentially impact risk. Having a second affected parent increased the risk of AUD additionally, and sustained exposure to parental EB across multiple periods resulted in a higher risk of young adult AUD than exposure in only one period. CONCLUSIONS: In this well-powered population study, there was no evidence of "sensitive periods" of exposure to national registry-ascertained parental EB with respect to impact on young adult AUD, but sustained exposure was more pathogenic than limited exposure. These findings suggest developmental timing does not meaningfully vary the impact, but rather there is a pervasive risk for development of young adult AUD for children and adolescents exposed to parental EB.
No figures extracted from this document.
| Name | Type |
|---|---|
| Adoptive parental externalizing behavior local | phenotype |
| adoptive parents | cohort |
| adult alcohol dependence | phenotype |
| alcohol | phenotype |
| alcoholic liver disease | phenotype |
| Alcohol induced pancreatitis local | phenotype |
| Alcohol Problems | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| Alcohol Use Disorder (young adult) local | phenotype |
| Antisocial or criminal behavior local | phenotype |
| antisocial personality disorder | phenotype |
| AUD | phenotype |
| behavior problems | phenotype |
| Biological_Families local | cohort |
| Biological parents | cohort |
| children | cohort |
| Children of affected parents local | cohort |
| Chronic child abuse exposure local | phenotype |
| Chronic parental externalizing behavior exposure local | phenotype |
| Cohort 1970–1974 local | cohort |
| Cohort 1975–1979 local | cohort |
| Cohort 1980–1984 local | cohort |
| crime | phenotype |
| Criminal History local | phenotype |
| depression | phenotype |
| drug dependence | phenotype |
| drug or alcohol problems local | phenotype |
| drugs | drug |
| EB exposure local | drug |
| environmental stress | phenotype |
| externalizing behavior | phenotype |
| Externalizing_Problems local | phenotype |
| family conflict | phenotype |
| Genetic_Liability local | phenotype |
| genetic variants | cohort |
| harsh parenting | phenotype |
| heavy drinking | phenotype |
| High parental education local | phenotype |
| Limited communication about alcohol use local | phenotype |
| maternal EB local | phenotype |
| maternal psychopathology | phenotype |
| Middle parental education local | phenotype |
| Multi-Generation Register local | cohort |
| multiple affected parents local | cohort |
| National Census Registry local | cohort |
| negative parenting | phenotype |
| offspring outcomes | cohort |
| parental alcoholism | phenotype |
| parental death | phenotype |
| parental depression | phenotype |
| Parental_EB local | phenotype |
| parental EB exposure local | drug |
| parental education | phenotype |
| parental externalizing behavior local | phenotype |
| Parental externalizing behavior local | phenotype |
| Parental Externalizing Behavior local | phenotype |
| parental monitoring | phenotype |
| parents with EB local | cohort |
| paternal EB local | phenotype |
| paternal psychopathology local | phenotype |
| Pathological drinking local | phenotype |
| physical abuse | phenotype |
| Post-Traumatic Stress Disorder | phenotype |
| property crime local | phenotype |
| sex | phenotype |
| single affected parent local | phenotype |
| study cohort | cohort |
| substance use | phenotype |
| Sweden | cohort |
| Swedish adoptees local | cohort |
| Swedish cohort 1970-1984 local | cohort |
| Swedish Crime Register | cohort |
| Swedish Hospital Discharge Register | cohort |
| Swedish population | cohort |
| Swedish register data local | cohort |
| Swedish residents local | cohort |
| Total Population Registry local | cohort |
| Toxic effects of alcohol local | phenotype |
| Two Affected Parents local | phenotype |
| violent behavior | phenotype |
| white collar crime local | phenotype |
| YoungAdult_AUD local | phenotype |
| young adults | cohort |
| young adults with AUD local | cohort |
| youngest parental cohort local | cohort |
No uploaded files.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Influence of Parental Alcohol Dependence Symptoms and Parenting on Adolescent Risky Drinking and Conduct Problems: A Family Systems Perspective. | 2018 | 29969154 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| From Binge Drinking to Future Alcohol Severity: The Role of Emotion Regulation and Emerging Psychopathology | Carbia C et al. | — | 2025 | — |
| Prediction of suicide attempt in a Swedish population-based cohort. | Lannoy S et al. | — | 2025 | → |
| All in the family: parental substance misuse, harsh parenting, and youth substance misuse among juvenile justice-involved youth. | Bosk EA et al. | — | 2021 | → |
| Childhood Experiences and High-Intensity Drinking Among American Indian and Alaska Native Adults: Findings From the 2000-2015 National Alcohol Surveys. | Greenfield TK et al. | — | 2021 | → |
| Young men's behavioral competencies and risk of alcohol use disorder in emerging adulthood: Early protective effects of parental education. | Karriker-Jaffe KJ et al. | — | 2021 | → |
| An upbringing with substance-abusing parents: Experiences of parentification and dysfunctional communication. | Tedgård E et al. | — | 2019 | → |
| Parental education and adolescent health problems due to violence, self-harm and substance use: what is the role of parental health problems? | Remes H et al. | — | 2019 | → |
| Chains of risk for alcohol use disorder: Mediators of exposure to neighborhood deprivation in early and middle childhood. | Karriker-Jaffe KJ et al. | — | 2018 | → |
| Influence of Parental Alcohol Dependence Symptoms and Parenting on Adolescent Risky Drinking and Conduct Problems: A Family Systems Perspective. | Su J et al. | — | 2018 | → |
| Alcoholism Detection by Data Augmentation and Convolutional Neural Network with Stochastic Pooling. | Wang SH et al. | — | 2017 | → |